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Title of the item:

How do community advisory boards fulfil their ethical role in HIV clinical trials? A protocol for a systematic review of qualitative evidence.

Title :
How do community advisory boards fulfil their ethical role in HIV clinical trials? A protocol for a systematic review of qualitative evidence.
Authors :
Pancras G; Department of Bioethics and Health Professionalism, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania .
Amour M; Department of Community Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania.
Mwakyandile T; Department of Clinical Pharmacology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania.
Morris B; Department of Nursing Management, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania.
Sunguya BF; Department of Community Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania.
Mmbaga B; Department of Paediatric, Kilimanjaro Christian Medical College, Kilimanjaro, United Republic of Tanzania.
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Source :
BMJ open [BMJ Open] 2020 Apr 30; Vol. 10 (4), pp. e035368. Date of Electronic Publication: 2020 Apr 30.
Publication Type :
Journal Article; Research Support, N.I.H., Extramural
Language :
English
Imprint Name(s) :
Original Publication: [London] : BMJ Publishing Group Ltd, 2011-
MeSH Terms :
Advisory Committees*
Ethics, Research*
HIV Infections*
Stakeholder Participation*
Systematic Reviews as Topic*
Clinical Trials as Topic ; Community Participation ; Humans ; Qualitative Research
References :
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JAMA. 2013 Nov 27;310(20):2191-4. (PMID: 24141714)
Health Res Policy Syst. 2009 Jun 17;7:16. (PMID: 19534798)
J Acquir Immune Defic Syndr. 2003 Aug 1;33(4):513-20. (PMID: 12869841)
Int J Evid Based Healthc. 2015 Sep;13(3):179-87. (PMID: 26262565)
J Am Coll Dent. 2014 Summer;81(3):4-13. (PMID: 25951677)
PLoS Med. 2009 Jul 21;6(7):e1000097. (PMID: 19621072)
Clin Trials. 2008;5(2):147-56. (PMID: 18375653)
JAMA. 2000 May 24-31;283(20):2701-11. (PMID: 10819955)
BMC Med Res Methodol. 2006 Jul 26;6:35. (PMID: 16872487)
Grant Information :
R25 TW011227 United States TW FIC NIH HHS
Contributed Indexing :
Keywords: HIV & AIDS*; clinical trials*; ethics (see medical ethics)*; qualitative research*
Entry Date(s) :
Date Created: 20200502 Date Completed: 20210217 Latest Revision: 20210217
Update Code :
20210914
PubMed Central ID :
PMC7213848
DOI :
10.1136/bmjopen-2019-035368
PMID :
32354781
Academic Journal
Introduction: Community advisory boards (CABs) continue to gain wide use and acceptance in global health research including in HIV clinical trials. They provide means through which community concerns regarding the trial can be considered by the research team, and provide an important platform of communication between the researchers and the community about study goals. Therefore, this systematic review protocol will guide the review of qualitative evidence on the ethical roles of CABs in HIV clinical trials based on the three fundamental ethical principles: respect for the person, beneficence and justice.
Methods and Analysis: This systematic review of qualitative evidence will involve searching four medical databases: PubMed, ScienceDirect, CINAHL and Cochrane Library. Additionally, other relevant evidence will be obtained through hand searching and grey literature. Searches will be limited to studies published in the English language from 1989 (the year that CABs were first established in HIV clinical trials) to 2019. Articles searched will be screened by two independent authors based on inclusion and exclusion criteria. Included articles will be appraised for quality using the Critical Appraisal Skills Programme checklist and followed by qualitative data extraction. Findings will be analysed based on the meta-aggregative approach with the aid of EPPI-Reviewer 4 web-based software.
Ethics and Dissemination: Ethical approval does not apply to this review. Data will be disseminated through scientific conferences and peer-reviewed journals to inform policies and stake-holders about the ethical role of CABs.
Prospero Registration Number: CRD42019133787.
(© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

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