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Tytuł pozycji:

Efficacy of topical steroid treatment in children with severe phimosis in China: A long-term single centre prospective study.

Tytuł :
Efficacy of topical steroid treatment in children with severe phimosis in China: A long-term single centre prospective study.
Autorzy :
Zhou G; Department of Urology and Laboratory of Pelvic Floor Muscle Function, Shenzhen Children's Hospital, Shenzhen, China.
Jiang M; Department of Infectious Disease, Shenzhen Children's Hospital, Shenzhen, China.
Yang Z; Department of Urology and Laboratory of Pelvic Floor Muscle Function, Shenzhen Children's Hospital, Shenzhen, China.
Xu W; Department of Urology and Laboratory of Pelvic Floor Muscle Function, Shenzhen Children's Hospital, Shenzhen, China.
Li S; Department of Urology and Laboratory of Pelvic Floor Muscle Function, Shenzhen Children's Hospital, Shenzhen, China.
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Źródło :
Journal of paediatrics and child health [J Paediatr Child Health] 2021 Jul 02. Date of Electronic Publication: 2021 Jul 02.
Publication Model :
Ahead of Print
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Melbourne ; Boston : Blackwell Scientific Publications, c1990-
References :
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Dewan PA, Tieu HC, Chieng BS. Phimosis: Is circumcision necessary? J. Paediatr. Child Health 1996; 32: 285-9.
Moreno G, Corbalán J, Peñaloza B, Pantoja T. Topical corticosteroids for treating phimosis in boys. Cochrane Database Syst. Rev. 2014; 2: 925-7.
Kikiros CS, Beasley SW, Woodward AA. The response of phimosis to local steroid application. Pediatr. Surg. Int. 1993; 8: 329-32.
Jorgensen ET, Svensson A. The treatment of phimosis in boys, with a potent topical steroid (clobetasol propionate 0.05%) cream. Acta Derm. Venereol. 1993; 73: 55-6.
Chu CC, Chen KC and Diau GY. Topical steroid treatment of phimosis in boys. J. Urol. 1999; 162(3 Pt 1):861-863.
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Sabino BL, Perez-Boscollo AC, Rocha LP et al. Foreskin analysis of circumcised boys with and without previous topical corticosteroid. Fetal Pediatr. Pathol. 2012; 31: 265-72.
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Chamberlin JD, Dorgalli C, Abdelhalim A, Davis-Dao CA, Khoury AE. Randomized open label trial comparing topical prescription triamcinolone to over-the-counter hydrocortisone for the treatment of phimosis. J. Pediatr. Urol. 2019; 15: 388.e1-5.
Silay MS, Hoen L, Quadackaers J et al. PT332 - Treatment of varicocele in children and adolescents: A systematic review and meta-analysis from European Association of Urology/European Society for Paediatric Urology Guidelines Panel. Eur. Urol. Suppl. 2019; 3: e2116. http://guide.medlive.cn/.
Nascimento FJ, Pereira RF, Silva JN, Tavares A, Pompeo AC. Topical betamethasone and hyaluronidase in the treatment of phimosis in boys: A double-blind, randomized, placebo-controlled trial. Int. Braz. J. Urol. 2011; 37: 314-9.
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Grant Information :
SZSM201612013 Sanming Project of Medicine in Shenzhen
Contributed Indexing :
Keywords: children; mometasone furoate; phimosis; steroid
Entry Date(s) :
Date Created: 20210702 Latest Revision: 20210702
Update Code :
20210914
DOI :
10.1111/jpc.15628
PMID :
34212436
Czasopismo naukowe
Aim: To evaluate the efficacy of topical steroid (0.1% mometasone furoate) therapy and factors affecting long-term outcome of paediatric severe phimosis in China.
Methods: A total of 1550 patients with severe phimosis classified by Kikiros system were prospectively enrolled in the study from January 2016 to February 2020. They were prescribed with 0.1% mometasone furoate twice a day for 4 weeks. Patients were re-evaluated at the end of weeks 2, 4, 8 and 6 months follow-up.
Results: A total of 1499 patients completed the treatment, 71.1% responded at the end of week 4. The long-term success rate was 66.0% over a mean follow-up of 26.9 months. The success rate of grade 4 phimosis was significantly higher than that of grade 5 at 4, 8 weeks and 6 months (P = 0.005, P < 0.001 and P < 0.001, respectively). Patients with balanoposthitis had a poorer outcome compared with patients without symptoms and patients symptoms by prepuce ballooning or urinary tract infections (P < 0.001). Initial grade of 5 phimosis and symptom with balanoposthitis were independent risk factors for recurrence. All patients had no systemic side effects, 23 cases developed local erythema or burning sensation.
Conclusion: Topical steroid (0.1% mometasone furoate) is an effective treatment for severe phimosis in children. The recurrence was related to the grade or symptoms of severe phimosis.
(© 2021 The Authors. Journal of Paediatrics and Child Health published by John Wiley & Sons Australia, Ltd on behalf of Paediatrics and Child Health Division (The Royal Australasian College of Physicians).)

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