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Tytuł :
4,7-Disubstituted 7 H -Pyrrolo[2,3-d]pyrimidines and Their Analogs as Antiviral Agents against Zika Virus.
Autorzy :
Soto-Acosta R; Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
Jung E; Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
Qiu L; Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
Wilson DJ; Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
Geraghty RJ; Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
Chen L; Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 22; Vol. 26 (13). Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents*/chemical synthesis
Antiviral Agents*/chemistry
Antiviral Agents*/pharmacology
Pyrimidines*/chemical synthesis
Pyrimidines*/chemistry
Pyrimidines*/pharmacology
Virus Replication/*drug effects
Zika Virus/*physiology
Zika Virus Infection/*drug therapy
Cell Line, Tumor ; Humans ; Zika Virus Infection/metabolism ; Zika Virus Infection/pathology
Czasopismo naukowe
Tytuł :
Dissecting the novel mechanism of reduning injection in treating Coronavirus Disease 2019 (COVID-19) based on network pharmacology and experimental verification.
Autorzy :
Jia S; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Luo H; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China. Electronic address: .
Liu X; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Fan X; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Huang Z; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Lu S; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Shen L; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Guo S; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Liu Y; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Wang Z; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China; The Key Laboratory for the New Technique Research of TCM Extraction and Purification, Lianyungang, Jiangsu, 222047, China. Electronic address: .
Cao L; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China; The Key Laboratory for the New Technique Research of TCM Extraction and Purification, Lianyungang, Jiangsu, 222047, China. Electronic address: .
Cao Z; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China; The Key Laboratory for the New Technique Research of TCM Extraction and Purification, Lianyungang, Jiangsu, 222047, China. Electronic address: .
Zhang X; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China; The Key Laboratory for the New Technique Research of TCM Extraction and Purification, Lianyungang, Jiangsu, 222047, China. Electronic address: .
Zhou W; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Zhang J; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Li J; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Wu J; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Xiao W; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China; The Key Laboratory for the New Technique Research of TCM Extraction and Purification, Lianyungang, Jiangsu, 222047, China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Jun 12; Vol. 273, pp. 113871. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*pharmacology
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Drugs, Chinese Herbal/*pharmacology
Drugs, Chinese Herbal/*therapeutic use
Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antiviral Agents/chemistry ; Antiviral Agents/toxicity ; Cell Line, Transformed ; Chlorocebus aethiops ; Computational Biology ; Coronavirus 3C Proteases/metabolism ; Coronavirus Papain-Like Proteases/metabolism ; Cytokines/metabolism ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/toxicity ; Humans ; Medicine, Chinese Traditional/methods ; Molecular Docking Simulation ; Protein Array Analysis ; SARS-CoV-2/drug effects ; Signal Transduction/drug effects ; Vero Cells
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Antiviral Peptides Targeting the Helicase Activity of Enterovirus Nonstructural Protein 2C.
Autorzy :
Fang Y; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Wang C; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.; The University of Chinese Academy of Sciences, Beijing, China.
Wang C; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Yang R; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.; The University of Chinese Academy of Sciences, Beijing, China.
Bai P; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.
Zhang XY; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Kong J; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.; The University of Chinese Academy of Sciences, Beijing, China.
Yin L; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.
Qiu Y; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.; The University of Chinese Academy of Sciences, Beijing, China.
Zhou X; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China .; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.; The University of Chinese Academy of Sciences, Beijing, China.
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Źródło :
Journal of virology [J Virol] 2021 May 24; Vol. 95 (12). Date of Electronic Publication: 2021 May 24 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Carrier Proteins/*antagonists & inhibitors
Enterovirus A, Human/*drug effects
Enterovirus Infections/*drug therapy
Peptides/*pharmacology
RNA Helicases/*antagonists & inhibitors
Viral Nonstructural Proteins/*antagonists & inhibitors
Animals ; Antiviral Agents/chemistry ; Antiviral Agents/therapeutic use ; Carrier Proteins/chemistry ; Carrier Proteins/metabolism ; Cell Line ; Drug Design ; Enterovirus A, Human/chemistry ; Enterovirus A, Human/physiology ; Enterovirus B, Human/drug effects ; Enterovirus B, Human/physiology ; Enterovirus Infections/virology ; Humans ; Mice ; Mice, Inbred ICR ; Peptides/chemistry ; Peptides/therapeutic use ; RNA Helicases/metabolism ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/metabolism ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Classification, structure and mechanism of antiviral polysaccharides derived from edible and medicinal fungus.
Autorzy :
Guo Y; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Chen X; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China; Shaanxi Research Institute of Agricultural Product Processing Technology, Xi'an 710021, China.
Gong P; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jul 31; Vol. 183, pp. 1753-1773. Date of Electronic Publication: 2021 May 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Anti-Inflammatory Agents*/chemistry
Anti-Inflammatory Agents*/classification
Anti-Inflammatory Agents*/therapeutic use
Antiviral Agents*/chemistry
Antiviral Agents*/classification
Antiviral Agents*/therapeutic use
Fungal Polysaccharides*/chemistry
Fungal Polysaccharides*/classification
Fungal Polysaccharides*/therapeutic use
Immunologic Factors*/chemistry
Immunologic Factors*/classification
Immunologic Factors*/therapeutic use
Agaricales/*chemistry
COVID-19/*drug therapy
SARS-CoV-2/*immunology
COVID-19/immunology ; COVID-19/prevention & control ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Microbiome/immunology ; Humans
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
A potential antiviral activity of Esculentoside A against binding interactions of SARS-COV-2 spike protein and angiotensin converting enzyme 2 (ACE2).
Autorzy :
Zeng MS; Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, PR China.
Yu WD; Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, PR China.
Wang HX; Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, PR China.
Liu JY; Basic Medical College, Guangzhou University of Chinese Medicine, Guangzhou, PR China.
Xu PP; Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, PR China. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jul 31; Vol. 183, pp. 2248-2261. Date of Electronic Publication: 2021 Jun 07.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme 2*/chemistry
Angiotensin-Converting Enzyme 2*/metabolism
Antiviral Agents*/chemistry
Antiviral Agents*/pharmacology
Molecular Docking Simulation*
Molecular Dynamics Simulation*
SARS-CoV-2*/chemistry
SARS-CoV-2*/physiology
Saponins*/chemistry
Saponins*/pharmacology
Spike Glycoprotein, Coronavirus*/chemistry
Spike Glycoprotein, Coronavirus*/metabolism
COVID-19/*drug therapy
Oleanolic Acid/*analogs & derivatives
Cell Line, Tumor ; Coronavirus OC43, Human/chemistry ; Coronavirus OC43, Human/metabolism ; Humans ; Oleanolic Acid/chemistry ; Oleanolic Acid/pharmacology
Czasopismo naukowe
Tytuł :
Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection.
Autorzy :
Dampalla CS; Department of Chemistry, Wichita State University, Wichita, KS 67260.
Zheng J; Department of Microbiology and Immunology, The University of Iowa, Iowa City, IA 52242.
Perera KD; Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506.
Wong LR; Department of Microbiology and Immunology, The University of Iowa, Iowa City, IA 52242.
Meyerholz DK; Department of Pathology, The University of Iowa, Iowa City, IA 52242.
Nguyen HN; Department of Chemistry, Wichita State University, Wichita, KS 67260.
Kashipathy MM; Protein Structure Laboratory, The University of Kansas, Lawrence, KS 66047.
Battaile KP; NYX, New York Structural Biology Center, Upton, NY 11973.
Lovell S; Protein Structure Laboratory, The University of Kansas, Lawrence, KS 66047.
Kim Y; Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506; .
Perlman S; Department of Microbiology and Immunology, The University of Iowa, Iowa City, IA 52242; .
Groutas WC; Department of Chemistry, Wichita State University, Wichita, KS 67260; .
Chang KO; Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jul 20; Vol. 118 (29).
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Coronavirus 3C Proteases/*antagonists & inhibitors
Coronavirus Papain-Like Proteases/*antagonists & inhibitors
Protease Inhibitors/*therapeutic use
Pyrrolidines/*therapeutic use
SARS-CoV-2/*drug effects
Angiotensin-Converting Enzyme 2/genetics ; Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; COVID-19/pathology ; Coronavirus 3C Proteases/chemistry ; Coronavirus Papain-Like Proteases/chemistry ; Crystallography, X-Ray ; Deuterium ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Female ; Lung/pathology ; Mice ; Mice, Transgenic ; Models, Molecular ; Molecular Structure ; Protease Inhibitors/chemical synthesis ; Protease Inhibitors/chemistry ; Protease Inhibitors/pharmacology ; Protein Conformation ; Pyrrolidines/chemistry ; SARS-CoV-2/enzymology ; Transgenes
Czasopismo naukowe
Tytuł :
Luteolin: a blocker of SARS-CoV-2 cell entry based on relaxed complex scheme, molecular dynamics simulation, and metadynamics.
Autorzy :
Shadrack DM; School of Life Science and Bio-engeering, The Nelson Mandela African Institute of Science and Technology, P.O.Box 447, Arusha, Tanzania. .; Department of Chemistry, Faculty of Natural and Applied Sciences, St John's University of Tanzania, P.O.Box 47, Dodoma, Tanzania. .
Deogratias G; Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O.Box 35061, Dar es Salaam, Tanzania. .; Department of Materials and Energy Science and Engineering, The Nelson Mandela African Institution of Science and Technology, P.O.Box 447, Arusha, Tanzania. .
Kiruri LW; Department of Chemistry, Kenyatta University, P.O.Box 43844-00100, Nairobi, Kenya.
Onoka I; Department of Chemistry, College of Natural and Mathematical Sciences, University of Dodoma, P.O.Box 338, Dodoma, Tanzania.
Vianney JM; School of Life Science and Bio-engeering, The Nelson Mandela African Institute of Science and Technology, P.O.Box 447, Arusha, Tanzania.
Swai H; School of Life Science and Bio-engeering, The Nelson Mandela African Institute of Science and Technology, P.O.Box 447, Arusha, Tanzania.
Nyandoro SS; Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O.Box 35061, Dar es Salaam, Tanzania.
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Źródło :
Journal of molecular modeling [J Mol Model] 2021 Jul 08; Vol. 27 (8), pp. 221. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Dynamics Simulation*
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Luteolin/*pharmacology
Plant Extracts/*pharmacology
SARS-CoV-2/*drug effects
Virus Internalization/*drug effects
Angiotensin-Converting Enzyme 2/metabolism ; Antiviral Agents/isolation & purification ; Antiviral Agents/metabolism ; Binding Sites ; COVID-19/virology ; Host-Pathogen Interactions ; Humans ; Kinetics ; Lamiaceae/chemistry ; Luteolin/isolation & purification ; Luteolin/metabolism ; Plant Extracts/isolation & purification ; Plant Extracts/metabolism ; Protein Binding ; Protein Conformation ; Receptors, Virus/metabolism ; SARS-CoV-2/pathogenicity ; Spike Glycoprotein, Coronavirus/metabolism
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Long-chain polyphosphates impair SARS-CoV-2 infection and replication.
Autorzy :
Ferrucci V; CEINGE Biotecnologie Avanzate, Naples 80145, Italy.; Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), 'Federico II' University of Naples, Naples 80131, Italy.
Kong DY; Ginxen Co., Ltd., 2F, Daewoong Building, Seocho-gu, Seoul, South Korea.
Asadzadeh F; CEINGE Biotecnologie Avanzate, Naples 80145, Italy.
Marrone L; CEINGE Biotecnologie Avanzate, Naples 80145, Italy.; Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), 'Federico II' University of Naples, Naples 80131, Italy.
Boccia A; Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), 'Federico II' University of Naples, Naples 80131, Italy.
Siciliano R; CEINGE Biotecnologie Avanzate, Naples 80145, Italy.
Criscuolo G; CEINGE Biotecnologie Avanzate, Naples 80145, Italy.; Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), 'Federico II' University of Naples, Naples 80131, Italy.
Anastasio C; CEINGE Biotecnologie Avanzate, Naples 80145, Italy.
Quarantelli F; CEINGE Biotecnologie Avanzate, Naples 80145, Italy.
Comegna M; CEINGE Biotecnologie Avanzate, Naples 80145, Italy.; Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), 'Federico II' University of Naples, Naples 80131, Italy.
Pisano I; CEINGE Biotecnologie Avanzate, Naples 80145, Italy.
Passariello M; CEINGE Biotecnologie Avanzate, Naples 80145, Italy.; Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), 'Federico II' University of Naples, Naples 80131, Italy.
Iacobucci I; CEINGE Biotecnologie Avanzate, Naples 80145, Italy.; Department of Chemical Sciences, University 'Federico II', Via Cinthia 4, Naples 80125, Italy.
Monica RD; CEINGE Biotecnologie Avanzate, Naples 80145, Italy.
Izzo B; CEINGE Biotecnologie Avanzate, Naples 80145, Italy.; Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), 'Federico II' University of Naples, Naples 80131, Italy.
Cerino P; Istituto Zooprofilattico Sperimentale del Mezzogiorno, Naples 80055, Italy.
Fusco G; Istituto Zooprofilattico Sperimentale del Mezzogiorno, Naples 80055, Italy.
Viscardi M; Istituto Zooprofilattico Sperimentale del Mezzogiorno, Naples 80055, Italy.
Brandi S; Istituto Zooprofilattico Sperimentale del Mezzogiorno, Naples 80055, Italy.
Pierri BM; Istituto Zooprofilattico Sperimentale del Mezzogiorno, Naples 80055, Italy.
Borriello G; Istituto Zooprofilattico Sperimentale del Mezzogiorno, Naples 80055, Italy.
Tiberio C; U.O.C. di Patologia Clinica Ospedale D. Cotugno, Azienda Sanitaria Ospedali dei Colli, Naples 80131, Italy.
Atripaldi L; U.O.C. di Patologia Clinica Ospedale D. Cotugno, Azienda Sanitaria Ospedali dei Colli, Naples 80131, Italy.
Bianchi M; Sapienza Università di Roma, Department of Biochemical Sciences 'A. Rossi Fanelli', Rome 00185, Italy.
Paolella G; CEINGE Biotecnologie Avanzate, Naples 80145, Italy.; Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), 'Federico II' University of Naples, Naples 80131, Italy.
Capoluongo E; CEINGE Biotecnologie Avanzate, Naples 80145, Italy.; DAI Medicina di Laboratorio e Trasfusionale, AOU Azienda Ospedaliera 'Federico II', Naples 80131, Italy.
Castaldo G; CEINGE Biotecnologie Avanzate, Naples 80145, Italy.; Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), 'Federico II' University of Naples, Naples 80131, Italy.
Chiariotti L; CEINGE Biotecnologie Avanzate, Naples 80145, Italy.; Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), 'Federico II' University of Naples, Naples 80131, Italy.
Monti M; CEINGE Biotecnologie Avanzate, Naples 80145, Italy.; Department of Chemical Sciences, University 'Federico II', Via Cinthia 4, Naples 80125, Italy.
De Lorenzo C; CEINGE Biotecnologie Avanzate, Naples 80145, Italy.; Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), 'Federico II' University of Naples, Naples 80131, Italy.
Yun KS; HaimBio Co. Ltd, Industrial Park, Korea University, Seongbuk-gu, Seoul, South Korea.
Pascarella S; Sapienza Università di Roma, Department of Biochemical Sciences 'A. Rossi Fanelli', Rome 00185, Italy.
Cheong JH; Department of Surgery, Yonsei University College of Medicine, Seoul, Korea. .
Kim HY; Ginxen Co., Ltd., 2F, Daewoong Building, Seocho-gu, Seoul, South Korea. .; HaimBio Co. Ltd, Industrial Park, Korea University, Seongbuk-gu, Seoul, South Korea.
Zollo M; CEINGE Biotecnologie Avanzate, Naples 80145, Italy. .; Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), 'Federico II' University of Naples, Naples 80131, Italy.; DAI Medicina di Laboratorio e Trasfusionale, AOU Azienda Ospedaliera 'Federico II', Naples 80131, Italy.
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Źródło :
Science signaling [Sci Signal] 2021 Jul 06; Vol. 14 (690). Date of Electronic Publication: 2021 Jul 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Polyphosphates/*pharmacology
SARS-CoV-2/*drug effects
Administration, Inhalation ; Amino Acid Sequence ; Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antiviral Agents/administration & dosage ; Antiviral Agents/chemistry ; COVID-19/metabolism ; COVID-19/virology ; Caco-2 Cells ; Chlorocebus aethiops ; Coronavirus RNA-Dependent RNA Polymerase/chemistry ; Coronavirus RNA-Dependent RNA Polymerase/genetics ; Coronavirus RNA-Dependent RNA Polymerase/metabolism ; Cytokines/metabolism ; HEK293 Cells ; Host Microbial Interactions/drug effects ; Host Microbial Interactions/genetics ; Host Microbial Interactions/physiology ; Humans ; In Vitro Techniques ; Models, Biological ; Molecular Docking Simulation ; Nebulizers and Vaporizers ; Polyphosphates/administration & dosage ; Polyphosphates/chemistry ; Proteasome Endopeptidase Complex/metabolism ; Protein Interaction Domains and Motifs ; Proteolysis/drug effects ; RNA, Viral/genetics ; RNA, Viral/metabolism ; SARS-CoV-2/genetics ; SARS-CoV-2/physiology ; Sequence Homology, Amino Acid ; Signal Transduction/drug effects ; Vero Cells ; Virus Replication/drug effects
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
Effect of Bamlanivimab vs Placebo on Incidence of COVID-19 Among Residents and Staff of Skilled Nursing and Assisted Living Facilities: A Randomized Clinical Trial.
Autorzy :
Cohen MS; Institute of Global Health and Infectious Diseases, University of North Carolina at Chapel Hill.
Nirula A; Eli Lilly and Co, Indianapolis, Indiana.
Mulligan MJ; New York University Langone Vaccine Center, Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York.
Novak RM; University of Illinois College of Medicine, Chicago.
Marovich M; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland.
Yen C; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland.
Stemer A; Indiana University School of Medicine, Gary.
Mayer SM; University of Illinois College of Medicine, Chicago.
Wohl D; Institute of Global Health and Infectious Diseases, University of North Carolina at Chapel Hill.
Brengle B; Brengle Family Medicine, Indianapolis, Indiana.
Montague BT; Division of Infectious Diseases, University of Colorado School of Medicine, Aurora.
Frank I; Division of Infectious Diseases, University of Pennsylvania Perelman School of Medicine, Philadelphia.
McCulloh RJ; University of Nebraska Medical Center, Omaha.
Fichtenbaum CJ; University of Cincinnati Academic Health Center, Cincinnati, Ohio.
Lipson B; Florida Primary and Specialty Care, Boca Raton.
Gabra N; Burke Internal Medicine & Research, Burke, Virginia.
Ramirez JA; Division of Infectious Diseases, University of Louisville School of Medicine, Louisville, Kentucky.
Thai C; private practice, Huntington Beach, California.
Chege W; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland.
Gomez Lorenzo MM; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland.
Sista N; FHI 360, Durham, North Carolina.
Farrior J; FHI 360, Durham, North Carolina.
Clement ME; Louisiana State University Health Sciences Center, New Orleans.
Brown ER; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Custer KL; Eli Lilly and Co, Indianapolis, Indiana.
Van Naarden J; Eli Lilly and Co, Indianapolis, Indiana.
Adams AC; Eli Lilly and Co, Indianapolis, Indiana.
Schade AE; Eli Lilly and Co, Indianapolis, Indiana.
Dabora MC; Eli Lilly and Co, Indianapolis, Indiana.
Knorr J; Eli Lilly and Co, Indianapolis, Indiana.
Price KL; Eli Lilly and Co, Indianapolis, Indiana.
Sabo J; Eli Lilly and Co, Indianapolis, Indiana.
Tuttle JL; Eli Lilly and Co, Indianapolis, Indiana.
Klekotka P; Eli Lilly and Co, Indianapolis, Indiana.
Shen L; Eli Lilly and Co, Indianapolis, Indiana.
Skovronsky DM; Eli Lilly and Co, Indianapolis, Indiana.
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Corporate Authors :
BLAZE-2 Investigators
Źródło :
JAMA [JAMA] 2021 Jul 06; Vol. 326 (1), pp. 46-55.
Typ publikacji :
Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal, Humanized/*therapeutic use
Antibodies, Neutralizing/*therapeutic use
Antiviral Agents/*therapeutic use
COVID-19/*prevention & control
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal, Humanized/adverse effects ; Antibodies, Monoclonal, Humanized/immunology ; Antiviral Agents/adverse effects ; Antiviral Agents/immunology ; Assisted Living Facilities ; COVID-19/epidemiology ; Double-Blind Method ; Drug Approval ; Female ; Health Personnel ; Humans ; Immunization, Passive ; Incidence ; Infusions, Intravenous ; Male ; Middle Aged ; SARS-CoV-2/isolation & purification ; Severity of Illness Index ; Skilled Nursing Facilities ; Young Adult
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
Synthesis, molecular docking, and in silico ADMET studies of 4-benzyl-1-(2,4,6-trimethyl-benzyl)-piperidine: Potential Inhibitor of SARS-CoV2.
Autorzy :
Nandini Asha R; Department of Chemistry and Research Centre, Pope's College (Autonomous), Sawyerpuram-628251, Affiliated to Manonmaniam Sundaranar University, Tirunelveli 627012, Tamil Nadu, India. Electronic address: .
Ravindran Durai Nayagam B; Department of Chemistry and Research Centre, Pope's College (Autonomous), Sawyerpuram-628251, Affiliated to Manonmaniam Sundaranar University, Tirunelveli 627012, Tamil Nadu, India. Electronic address: .
Bhuvanesh N; Department of Chemistry, Texas A&M University, College Station, TX 77842, USA. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2021 Jul; Vol. 112, pp. 104967. Date of Electronic Publication: 2021 May 05.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*metabolism
Piperidines/*chemistry
SARS-CoV-2/*metabolism
Spike Glycoprotein, Coronavirus/*antagonists & inhibitors
Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/chemistry ; Adenosine Monophosphate/metabolism ; Alanine/analogs & derivatives ; Alanine/chemistry ; Alanine/metabolism ; Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Binding Sites ; COVID-19/pathology ; COVID-19/virology ; Crystallography, X-Ray ; Density Functional Theory ; Half-Life ; Humans ; Molecular Conformation ; Molecular Docking Simulation ; Piperidines/chemical synthesis ; Piperidines/metabolism ; SARS-CoV-2/isolation & purification ; Spike Glycoprotein, Coronavirus/metabolism ; Viral Matrix Proteins/antagonists & inhibitors ; Viral Matrix Proteins/metabolism
Czasopismo naukowe
Tytuł :
Marine sulfated polysaccharides as potential antiviral drug candidates to treat Corona Virus disease (COVID-19).
Autorzy :
Andrew M; Department of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India.
Jayaraman G; Department of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India. Electronic address: .
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Źródło :
Carbohydrate research [Carbohydr Res] 2021 Jul; Vol. 505, pp. 108326. Date of Electronic Publication: 2021 May 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Anticoagulants/*therapeutic use
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Immunologic Factors/*therapeutic use
Polysaccharides/*therapeutic use
Pulmonary Embolism/*drug therapy
Respiratory Insufficiency/*drug therapy
Anticoagulants/chemistry ; Anticoagulants/isolation & purification ; Antiviral Agents/chemistry ; Antiviral Agents/isolation & purification ; Blood Platelets/drug effects ; Blood Platelets/pathology ; Blood Platelets/virology ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/virology ; Humans ; Immunologic Factors/chemistry ; Immunologic Factors/isolation & purification ; Lung/blood supply ; Lung/drug effects ; Lung/pathology ; Lung/virology ; Phaeophyta/chemistry ; Polysaccharides/chemistry ; Polysaccharides/isolation & purification ; Pulmonary Embolism/complications ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/virology ; Respiratory Insufficiency/complications ; Respiratory Insufficiency/diagnosis ; Respiratory Insufficiency/virology ; Rhodophyta/chemistry ; SARS-CoV-2/drug effects ; SARS-CoV-2/pathogenicity ; Sulfuric Acid Esters/chemistry ; Virus Attachment/drug effects ; Virus Internalization/drug effects
Czasopismo naukowe
Tytuł :
Antiviral potential of plant polysaccharide nanoparticles actuating non-specific immunity.
Autorzy :
Stovbun SV; N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
Kalinina TS; Federal State Budgetary Institution, Research Zakusov Institute of Pharmacology, Moscow, Russia.
Zlenko DV; N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, Russia; M.V. Lomonosov Moscow State University, Moscow, Russia; A.N. Severtsov Institute of Ecology and Evolution, Moscow, Russia. Electronic address: .
Kiselev AV; N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
Litvin AA; Federal Research and Clinical Center of Physical-Chemical Medicine FMBA, Russia.
Bukhvostov AA; N.I. Pirogov Russian, National Research Medical University, Moscow, Russia.
Usachev SV; N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
Kuznetsov DA; N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, Russia; N.I. Pirogov Russian, National Research Medical University, Moscow, Russia.
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jul 01; Vol. 182, pp. 743-749. Date of Electronic Publication: 2021 Apr 05.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents*/chemistry
Antiviral Agents*/pharmacokinetics
Antiviral Agents*/pharmacology
Drug Carriers*/chemistry
Drug Carriers*/pharmacokinetics
Drug Carriers*/pharmacology
Nanoparticles*/chemistry
Nanoparticles*/therapeutic use
Polysaccharides*/chemistry
Polysaccharides*/pharmacology
Probucol*/chemistry
Probucol*/pharmacokinetics
Probucol*/pharmacology
COVID-19/*drug therapy
Plants/*chemistry
Adolescent ; Adult ; HL-60 Cells ; Humans ; Male ; Phagocytosis/drug effects
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Corilagin prevents SARS-CoV-2 infection by targeting RBD-ACE2 binding.
Autorzy :
Yang LJ; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China.
Chen RH; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China.
Hamdoun S; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China; Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.
Coghi P; School of Pharmacy, Macau University of Science and Technology, Macau, China.
Ng JPL; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China.
Zhang DW; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China.
Guo X; Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University, Foshan, Guangdong, 528000, China.
Xia C; Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University, Foshan, Guangdong, 528000, China.
Law BYK; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China. Electronic address: .
Wong VKW; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Jul; Vol. 87, pp. 153591. Date of Electronic Publication: 2021 May 05.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme 2/*metabolism
Antiviral Agents/*pharmacology
Glucosides/*pharmacology
Host-Pathogen Interactions/*drug effects
Hydrolyzable Tannins/*pharmacology
Spike Glycoprotein, Coronavirus/*metabolism
Angiotensin-Converting Enzyme 2/chemistry ; Animals ; Antiviral Agents/chemistry ; Antiviral Agents/toxicity ; COVID-19 ; Epstein-Barr Virus Infections/drug therapy ; Glucosides/chemistry ; Glucosides/toxicity ; HEK293 Cells ; Humans ; Hydrolyzable Tannins/chemistry ; Hydrolyzable Tannins/toxicity ; Lentivirus Infections/drug therapy ; Male ; Maximum Tolerated Dose ; Mice, Inbred C57BL ; Molecular Docking Simulation ; Spike Glycoprotein, Coronavirus/chemistry
Czasopismo naukowe
Tytuł :
Ebsulfur and Ebselen as highly potent scaffolds for the development of potential SARS-CoV-2 antivirals.
Autorzy :
Sun LY; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China.
Chen C; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China.
Su J; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China.
Li JQ; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China.
Jiang Z; Department of Pharmacy, General Hospital of Southern Theatre Command of PLA, Guangzhou 510010, PR China.
Gao H; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China.
Chigan JZ; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China.
Ding HH; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China.
Zhai L; Shaanxi Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 72101, Shaanxi Province, PR China.
Yang KW; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2021 Jul; Vol. 112, pp. 104889. Date of Electronic Publication: 2021 Apr 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*metabolism
Azoles/*metabolism
Organoselenium Compounds/*metabolism
SARS-CoV-2/*metabolism
Sulfur Compounds/*metabolism
Viral Matrix Proteins/*metabolism
Antiviral Agents/chemistry ; Antiviral Agents/therapeutic use ; Azoles/chemistry ; Azoles/therapeutic use ; Binding Sites ; COVID-19/drug therapy ; COVID-19/pathology ; COVID-19/virology ; Catalytic Domain ; Fluorescence Resonance Energy Transfer ; Humans ; Inhibitory Concentration 50 ; Kinetics ; Molecular Docking Simulation ; Organoselenium Compounds/chemistry ; Organoselenium Compounds/therapeutic use ; SARS-CoV-2/isolation & purification ; Structure-Activity Relationship ; Sulfur Compounds/chemistry ; Sulfur Compounds/therapeutic use ; Viral Matrix Proteins/antagonists & inhibitors ; Viral Matrix Proteins/genetics
Czasopismo naukowe
Tytuł :
Effectiveness and safety of favipiravir compared to supportive care in moderately to critically ill COVID-19 patients: a retrospective study with propensity score matching sensitivity analysis.
Autorzy :
Alamer A; Center for Health Outcomes and PharmacoEconomic Research, University of Arizona, Tucson, AZ, USA.; Department of Clinical Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.
Alrashed AA; Clinical Pharmacy Department, King Fahad Medical City, Riyadh, Saudi Arabia.
Alfaifi M; Clinical Pharmacy Department, King Saud Medical City, Riyadh, Saudi Arabia.
Alosaimi B; Research Center, King Fahad Medical City, Riyadh, Saudi Arabia.
AlHassar F; Department of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Almutairi M; Department of Pharmacy Practice, College of Pharmacy, Almaarefa University, Riyadh, Saudi Arabia.
Howaidi J; Clinical Pharmacy Department, King Fahad Medical City, Riyadh, Saudi Arabia.
Almutairi W; Department of Clinical Pharmacy, Shaqra University, Riyadh, Saudi Arabia.
Mohzari Y; Clinical Pharmacy Department, King Saud Medical City, Riyadh, Saudi Arabia.
Sulaiman T; Department of Infectious Diseases, King Fahad Medical City, Riyadh, Saudi Arabia.
Al-Jedai A; Ministry of Health, Deputyship of Therapeutic Affairs, Riyadh, Saudi Arabia.; Alfaisal University, Colleges of Pharmacy and Medicine, Riyadh, Saudi Arabia.
Alajami HN; Pharmaceutical Services Administration, King Saud Medical City, Riyadh, Saudi Arabia.
Alkharji F; Clinical Pharmacy Department, King Fahad Medical City, Riyadh, Saudi Arabia.
Alsaeed A; Neurology Department, King Fahad Medical City, Riyadh, Saudi Arabia.
Alali AH; Department of Infectious Diseases, King Saud Medical City, Riyadh, Saudi Arabia.
Baredhwan AA; Department of Infectious Diseases, King Saud Medical City, Riyadh, Saudi Arabia.
Abraham I; Center for Health Outcomes and PharmacoEconomic Research, University of Arizona, Tucson, AZ, USA.; Department of Pharmacy Practice and Science, College of Pharmacy, University of Arizona, Tucson, AZ, USA.
Almulhim AS; Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.
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Źródło :
Current medical research and opinion [Curr Med Res Opin] 2021 Jul; Vol. 37 (7), pp. 1085-1097. Date of Electronic Publication: 2021 May 19.
Typ publikacji :
Journal Article
MeSH Terms :
Amides*/adverse effects
Amides*/therapeutic use
Antiviral Agents*/adverse effects
Antiviral Agents*/therapeutic use
COVID-19*/epidemiology
COVID-19*/therapy
Pyrazines*/adverse effects
Pyrazines*/therapeutic use
Critical Illness/epidemiology ; Critical Illness/therapy ; Humans ; Propensity Score ; Respiration, Artificial/statistics & numerical data ; Retrospective Studies ; SARS-CoV-2 ; Saudi Arabia ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
Identification of 13 Guanidinobenzoyl- or Aminidinobenzoyl-Containing Drugs to Potentially Inhibit TMPRSS2 for COVID-19 Treatment.
Autorzy :
Huang X; Department of Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA.
Pearce R; Department of Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA.
Omenn GS; Department of Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA.; Departments of Internal Medicine and Human Genetics and School of Public Health, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA.
Zhang Y; Department of Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA.; Department of Biological Chemistry, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 30; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 30.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*chemistry
Serine Endopeptidases/*metabolism
Serine Proteinase Inhibitors/*chemistry
Antiviral Agents/metabolism ; Antiviral Agents/therapeutic use ; Benzamidines/chemistry ; Benzamidines/metabolism ; Binding Sites ; COVID-19/drug therapy ; COVID-19/pathology ; COVID-19/virology ; Catalytic Domain ; Esters/chemistry ; Esters/metabolism ; Guanidines/chemistry ; Guanidines/metabolism ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Serine Endopeptidases/chemistry ; Serine Proteinase Inhibitors/metabolism ; Serine Proteinase Inhibitors/therapeutic use ; Thermodynamics
Czasopismo naukowe
Tytuł :
Seleno-Functionalization of Quercetin Improves the Non-Covalent Inhibition of M and Its Antiviral Activity in Cells against SARS-CoV-2.
Autorzy :
Mangiavacchi F; Group of Catalysis, Synthesis and Organic Green Chemistry, Department of Pharmaceutical Sciences, University of Perugia Via del Liceo 1, 06100 Perugia, Italy.
Botwina P; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland.; Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
Menichetti E; Group of Catalysis, Synthesis and Organic Green Chemistry, Department of Pharmaceutical Sciences, University of Perugia Via del Liceo 1, 06100 Perugia, Italy.; School of Science and Technology, Chemistry Division, University of Camerino, Via S. Agostino, 62032 Camerino, Italy.
Bagnoli L; Group of Catalysis, Synthesis and Organic Green Chemistry, Department of Pharmaceutical Sciences, University of Perugia Via del Liceo 1, 06100 Perugia, Italy.
Rosati O; Group of Catalysis, Synthesis and Organic Green Chemistry, Department of Pharmaceutical Sciences, University of Perugia Via del Liceo 1, 06100 Perugia, Italy.
Marini F; Group of Catalysis, Synthesis and Organic Green Chemistry, Department of Pharmaceutical Sciences, University of Perugia Via del Liceo 1, 06100 Perugia, Italy.
Fonseca SF; Laboratório de Síntese Orgânica Limpa-LASOL, CCQFA, Universidade Federal de Pelotas-UFPel, P.O. Box 354, 96010-900 Pelotas, Brazil.
Abenante L; Laboratório de Síntese Orgânica Limpa-LASOL, CCQFA, Universidade Federal de Pelotas-UFPel, P.O. Box 354, 96010-900 Pelotas, Brazil.
Alves D; Laboratório de Síntese Orgânica Limpa-LASOL, CCQFA, Universidade Federal de Pelotas-UFPel, P.O. Box 354, 96010-900 Pelotas, Brazil.
Dabrowska A; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland.; Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
Kula-Pacurar A; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland.
Ortega-Alarcon D; Institute for Biocomputation and Physics of Complex Systems (BIFI), Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Universidad de Zaragoza, 50018 Zaragoza, Spain.; Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, 50009 Zaragoza, Spain.
Jimenez-Alesanco A; Institute for Biocomputation and Physics of Complex Systems (BIFI), Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Universidad de Zaragoza, 50018 Zaragoza, Spain.; Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, 50009 Zaragoza, Spain.
Ceballos-Laita L; Institute for Biocomputation and Physics of Complex Systems (BIFI), Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Universidad de Zaragoza, 50018 Zaragoza, Spain.; Instituto de Investigación Sanitaria de Aragón (IIS Aragon), 50009 Zaragoza, Spain.
Vega S; Institute for Biocomputation and Physics of Complex Systems (BIFI), Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Universidad de Zaragoza, 50018 Zaragoza, Spain.
Rizzuti B; Institute for Biocomputation and Physics of Complex Systems (BIFI), Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Universidad de Zaragoza, 50018 Zaragoza, Spain.; CNR-NANOTEC, SS Rende (CS), Licryl-UOS Cosenza and CEMIF.Cal, Department of Physics, University of Calabria, 87036 Rende, Italy.
Abian O; Institute for Biocomputation and Physics of Complex Systems (BIFI), Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Universidad de Zaragoza, 50018 Zaragoza, Spain.; Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, 50009 Zaragoza, Spain.; Instituto de Investigación Sanitaria de Aragón (IIS Aragon), 50009 Zaragoza, Spain.; Instituto Aragonés de Ciencias de la Salud (IACS), 50009 Zaragoza, Spain.; Centro de Investigación Biomédica en Red en el Área Temática de Enfermedades Hepáticas Digestivas (CIBERehd), 28029 Madrid, Spain.
Lenardão EJ; Laboratório de Síntese Orgânica Limpa-LASOL, CCQFA, Universidade Federal de Pelotas-UFPel, P.O. Box 354, 96010-900 Pelotas, Brazil.
Velazquez-Campoy A; Institute for Biocomputation and Physics of Complex Systems (BIFI), Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Universidad de Zaragoza, 50018 Zaragoza, Spain.; Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, 50009 Zaragoza, Spain.; Instituto de Investigación Sanitaria de Aragón (IIS Aragon), 50009 Zaragoza, Spain.; Centro de Investigación Biomédica en Red en el Área Temática de Enfermedades Hepáticas Digestivas (CIBERehd), 28029 Madrid, Spain.; Fundación ARAID, Gobierno de Aragón, 50018 Zaragoza, Spain.
Pyrc K; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland.
Sancineto L; Group of Catalysis, Synthesis and Organic Green Chemistry, Department of Pharmaceutical Sciences, University of Perugia Via del Liceo 1, 06100 Perugia, Italy.
Santi C; Group of Catalysis, Synthesis and Organic Green Chemistry, Department of Pharmaceutical Sciences, University of Perugia Via del Liceo 1, 06100 Perugia, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 30; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 30.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*chemistry
Quercetin/*chemistry
SARS-CoV-2/*metabolism
Selenium/*chemistry
Viral Matrix Proteins/*antagonists & inhibitors
Animals ; Antiviral Agents/metabolism ; Antiviral Agents/pharmacology ; Binding Sites ; COVID-19/pathology ; COVID-19/virology ; Catalytic Domain ; Chlorocebus aethiops ; Humans ; Hydrogen Bonding ; Molecular Docking Simulation ; Protease Inhibitors/chemistry ; Protease Inhibitors/metabolism ; Protease Inhibitors/pharmacology ; Quercetin/metabolism ; Quercetin/pharmacology ; SARS-CoV-2/isolation & purification ; Selenium/metabolism ; Vero Cells ; Viral Matrix Proteins/metabolism ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Photosensitizing Antivirals.
Autorzy :
Mariewskaya KA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.; Higher Chemical College of the Russian Academy of Sciences, Mendeleev University of Chemical Technology, Miusskaya sq. 9, 125047 Moscow, Russia.
Tyurin AP; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.; Gause Institute of New Antibiotics, B. Pirogovskaya 11, 119021 Moscow, Russia.
Chistov AA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Korshun VA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Alferova VA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.; Gause Institute of New Antibiotics, B. Pirogovskaya 11, 119021 Moscow, Russia.
Ustinov AV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 29; Vol. 26 (13). Date of Electronic Publication: 2021 Jun 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antiviral Agents*/chemistry
Antiviral Agents*/pharmacokinetics
Antiviral Agents*/therapeutic use
Photosensitizing Agents*/chemistry
Photosensitizing Agents*/pharmacokinetics
Photosensitizing Agents*/therapeutic use
Virus Diseases*/drug therapy
Virus Diseases*/metabolism
Membrane Lipids/*metabolism
Viral Envelope/*metabolism
Viruses/*metabolism
Animals ; Humans ; Singlet Oxygen
Czasopismo naukowe
Tytuł :
Hairy Roots of Scutellaria spp. ( Lamiaceae ) as Promising Producers of Antiviral Flavones.
Autorzy :
Stepanova AY; Group of Specialized Root Metabolism, K.A. Timiryazev Institute of Plant Physiology RAS, 127276 Moscow, Russia.
Solov'eva AI; Group of Specialized Root Metabolism, K.A. Timiryazev Institute of Plant Physiology RAS, 127276 Moscow, Russia.
Malunova MV; Group of Specialized Root Metabolism, K.A. Timiryazev Institute of Plant Physiology RAS, 127276 Moscow, Russia.
Salamaikina SA; Group of Specialized Root Metabolism, K.A. Timiryazev Institute of Plant Physiology RAS, 127276 Moscow, Russia.
Panov YM; Faculty of Chemistry, Moscow State University, 119991 Moscow, Russia.
Lelishentsev AA; Bioanalytical Laboratory, Institute of Clinical Research and Pharmaceutical Expertise, 115088 Moscow, Russia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 27; Vol. 26 (13). Date of Electronic Publication: 2021 Jun 27.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*chemistry
Flavones/*chemistry
Scutellaria/*chemistry
Agrobacterium/growth & development ; Agrobacterium/metabolism ; Antiviral Agents/isolation & purification ; Antiviral Agents/pharmacology ; Chromatography, High Pressure Liquid ; Flavones/isolation & purification ; Flavones/pharmacology ; Plant Cells/metabolism ; Plant Extracts/chemistry ; Plant Roots/chemistry ; Plant Roots/metabolism ; Scutellaria/growth & development ; Scutellaria/metabolism ; Tandem Mass Spectrometry
SCR Organism :
Agrobacterium rhizogenes
Czasopismo naukowe
Tytuł :
Flavonoids as Promising Antiviral Agents against SARS-CoV-2 Infection: A Mechanistic Review.
Autorzy :
Khazeei Tabari MA; Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.; USERN Office, Mazandaran University of Medical Sciences, Sari, Iran.
Iranpanah A; Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.; Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.; Kermanshah USERN Office, Universal Scientific Education and Research Network (USERN), Kermanshah, Iran.
Bahramsoltani R; Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran P.O. Box 1417653761, Iran.; Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran.; PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Rahimi R; Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran P.O. Box 1417653761, Iran.; PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 25; Vol. 26 (13). Date of Electronic Publication: 2021 Jun 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Flavonoids/*pharmacology
Phytochemicals/*pharmacology
SARS-CoV-2/*drug effects
Animals ; Antiviral Agents/chemistry ; Antiviral Agents/therapeutic use ; Flavonoids/chemistry ; Flavonoids/therapeutic use ; Humans ; Phytochemicals/chemistry ; Phytochemicals/therapeutic use ; Signal Transduction/drug effects
Czasopismo naukowe

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