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Tytuł :
Exploring the SSBreakome: genome-wide mapping of DNA single-strand breaks by next-generation sequencing.
Autorzy :
Zilio N; Institute of Molecular Biology (IMB) gGmbH, Mainz, Germany.
Ulrich HD; Institute of Molecular Biology (IMB) gGmbH, Mainz, Germany.
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Źródło :
The FEBS journal [FEBS J] 2021 Jul; Vol. 288 (13), pp. 3948-3961. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
DNA Breaks, Single-Stranded*
DNA Repair*
Chromosome Mapping/*methods
DNA/*genetics
High-Throughput Nucleotide Sequencing/*methods
DNA/metabolism ; DNA Breaks, Double-Stranded ; DNA Damage ; DNA Replication ; Genome, Human/genetics ; Humans
Czasopismo naukowe
Tytuł :
Common Kinetic Mechanism of Abasic Site Recognition by Structurally Different Apurinic/Apyrimidinic Endonucleases.
Autorzy :
Kuznetsova AA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Senchurova SI; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia.
Ishchenko AA; Group Mechanisms of DNA Repair and Carcinogenesis, Equipe Labellisée LIGUE 2016, CNRS UMR9019, Gustave Roussy Cancer Campus, Université Paris-Saclay, F-94805 Villejuif, France.
Saparbaev M; Group Mechanisms of DNA Repair and Carcinogenesis, Equipe Labellisée LIGUE 2016, CNRS UMR9019, Gustave Roussy Cancer Campus, Université Paris-Saclay, F-94805 Villejuif, France.
Fedorova OS; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Kuznetsov NA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 18; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 18.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Cleavage*
DNA Damage*
DNA-(Apurinic or Apyrimidinic Site) Lyase/*chemistry
DNA-(Apurinic or Apyrimidinic Site) Lyase/*metabolism
Nucleotides/*metabolism
Binding Sites ; Catalytic Domain ; DNA Repair ; Escherichia coli ; Humans ; Kinetics ; Molecular Dynamics Simulation ; Nucleic Acid Conformation ; Nucleotides/chemistry ; Protein Conformation ; Substrate Specificity
Czasopismo naukowe
Tytuł :
DNA polymerase λ promotes error-free replication through Watson-Crick impairing N1-methyl-deoxyadenosine adduct in conjunction with DNA polymerase ζ.
Autorzy :
Yoon JH; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.
Basu D; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.
Choudhury JR; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.
Prakash S; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.
Prakash L; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Jul; Vol. 297 (1), pp. 100868. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
DNA Replication*
Adenosine Monophosphate/*analogs & derivatives
DNA Polymerase beta/*metabolism
Adenosine Monophosphate/metabolism ; Base Pairing ; Cell Line ; DNA Adducts/metabolism ; DNA-Directed DNA Polymerase/metabolism ; Humans ; Mutation
Czasopismo naukowe
Tytuł :
Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini.
Autorzy :
Schimmel J; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Muñoz-Subirana N; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Kool H; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
van Schendel R; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Tijsterman M; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. .; Institute of Biology Leiden, Leiden University, Leiden, The Netherlands. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 10; Vol. 12 (1), pp. 4843. Date of Electronic Publication: 2021 Aug 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA Polymerase I/*metabolism
DNA Primase/*metabolism
Microsatellite Repeats/*genetics
Telomere-Binding Proteins/*metabolism
Animals ; Base Sequence ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Line ; Cells, Cultured ; DNA End-Joining Repair ; DNA Polymerase I/genetics ; DNA Primase/genetics ; DNA, Single-Stranded ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Humans ; Mice ; Multiprotein Complexes/genetics ; Multiprotein Complexes/metabolism ; Mutation ; Telomere/genetics ; Telomere/metabolism ; Telomere-Binding Proteins/genetics ; Tumor Suppressor p53-Binding Protein 1/genetics ; Tumor Suppressor p53-Binding Protein 1/metabolism
Czasopismo naukowe
Tytuł :
The influence of DNA methylation on the sequence specificity of UVB- and UVC-induced DNA damage.
Autorzy :
Leung WY; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Murray V; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: .
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Źródło :
Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2021 Aug; Vol. 221, pp. 112225. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Methylation*
Ultraviolet Rays*
DNA Damage/*radiation effects
Base Sequence ; DNA/chemistry ; DNA/metabolism ; Electrophoresis, Capillary ; Humans ; Nucleic Acid Amplification Techniques ; Pyrimidine Dimers/analysis
Czasopismo naukowe
Tytuł :
RecA finds homologous DNA by reduced dimensionality search.
Autorzy :
Wiktor J; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Gynnå AH; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Leroy P; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Larsson J; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Coceano G; Department of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden.
Testa I; Department of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden.
Elf J; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden. .
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Źródło :
Nature [Nature] 2021 Sep; Vol. 597 (7876), pp. 426-429. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Biological*
Recombinational DNA Repair*
Sequence Homology, Nucleic Acid*
DNA, Bacterial/*metabolism
Escherichia coli/*enzymology
Escherichia coli/*genetics
Rec A Recombinases/*metabolism
DNA Breaks, Double-Stranded ; DNA, Single-Stranded/metabolism ; Time Factors
Czasopismo naukowe
Tytuł :
Dpb4 promotes resection of DNA double-strand breaks and checkpoint activation by acting in two different protein complexes.
Autorzy :
Casari E; Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano-Bicocca, Milano, Italy.
Gobbini E; Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano-Bicocca, Milano, Italy.
Gnugnoli M; Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano-Bicocca, Milano, Italy.
Mangiagalli M; Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano-Bicocca, Milano, Italy.
Clerici M; Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano-Bicocca, Milano, Italy.
Longhese MP; Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano-Bicocca, Milano, Italy. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 06; Vol. 12 (1), pp. 4750. Date of Electronic Publication: 2021 Aug 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA Polymerase II/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Adenosine Triphosphatases/metabolism ; Chromatin Assembly and Disassembly ; DNA/metabolism ; DNA Damage ; DNA Repair ; Histones/metabolism ; Mutation ; Transcription Factors
Czasopismo naukowe
Tytuł :
Instability in NAD metabolism leads to impaired cardiac mitochondrial function and communication.
Autorzy :
Lauritzen KH; Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet and University of Oslo, Oslo, Norway.
Olsen MB; Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet and University of Oslo, Oslo, Norway.
Ahmed MS; Institute for Surgical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.
Yang K; Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet and University of Oslo, Oslo, Norway.
Rinholm JE; Department of Microbiology, Oslo University Hospital, Oslo, Norway.
Bergersen LH; Department of Oral Biology, University of Oslo, Oslo, Norway.; Department of Neuroscience and Pharmacology, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Esbensen QY; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Nordbyhagen, Norway.
Sverkeli LJ; Department of Biomedicine, University of Bergen, Bergen, Norway.
Ziegler M; Department of Biomedicine, University of Bergen, Bergen, Norway.
Attramadal H; Institute for Surgical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.
Halvorsen B; Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet and University of Oslo, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Faculty of Medicine, Oslo, Norway.
Aukrust P; Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet and University of Oslo, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Faculty of Medicine, Oslo, Norway.; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Yndestad A; Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet and University of Oslo, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Faculty of Medicine, Oslo, Norway.
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Źródło :
ELife [Elife] 2021 Aug 03; Vol. 10. Date of Electronic Publication: 2021 Aug 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair*
DNA, Mitochondrial/*metabolism
Heart/*physiopathology
Heart Diseases/*physiopathology
Myocardium/*metabolism
NAD/*metabolism
Animals ; DNA Damage ; HeLa Cells ; Humans ; Mice ; Mitochondria/metabolism ; Niacinamide/adverse effects ; Niacinamide/analogs & derivatives ; Niacinamide/metabolism ; Pyridinium Compounds/adverse effects ; Sirtuins/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
RNase H1C collaborates with ssDNA binding proteins WHY1/3 and recombinase RecA1 to fulfill the DNA damage repair in Arabidopsis chloroplasts.
Autorzy :
Wang W; Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.; Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.
Li K; Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.; Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.
Yang Z; Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Hou Q; Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Zhao WW; Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.; Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.
Sun Q; Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.; Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jul 09; Vol. 49 (12), pp. 6771-6787.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Recombinational DNA Repair*
Arabidopsis/*genetics
Arabidopsis Proteins/*metabolism
Chloroplasts/*genetics
DNA-Binding Proteins/*metabolism
Rec A Recombinases/*metabolism
Arabidopsis/enzymology ; Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Chloroplasts/enzymology ; Chloroplasts/metabolism ; DNA Damage ; DNA, Plant/metabolism ; DNA-Binding Proteins/genetics ; DNA-Directed DNA Polymerase/genetics ; Genomic Instability ; Mutation ; RNA, Plant/metabolism
Czasopismo naukowe
Tytuł :
Comparison of DNA typing success in compromised blood and touch samples based on sampling swab composition.
Autorzy :
Smith C; Department of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.
Cox JO; Department of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.
Rhodes C; Department of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.
Lewis C; Department of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.
Koroma M; Department of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.
Hudson BC; Department of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.
Dawson Cruz T; Department of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.
Seashols-Williams SJ; Department of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.
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Źródło :
Journal of forensic sciences [J Forensic Sci] 2021 Jul; Vol. 66 (4), pp. 1427-1434. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
DNA Fingerprinting*
DNA/*analysis
Specimen Handling/*instrumentation
Blood Chemical Analysis ; DNA Degradation, Necrotic ; Electrophoresis, Capillary ; Humans ; Microsatellite Repeats ; Polymerase Chain Reaction ; Specimen Handling/methods ; Touch
Czasopismo naukowe
Tytuł :
Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase.
Autorzy :
Capella M; Department of Physiological Chemistry, BioMedical Center (BMC), Ludwig-Maximillians-Universität München, Planegg-Martinsried, Germany. .; Max Planck Institute of Biochemistry, Molecular Cell Biology, Planegg-Martinsried, Germany. .
Mandemaker IK; Department of Physiological Chemistry, BioMedical Center (BMC), Ludwig-Maximillians-Universität München, Planegg-Martinsried, Germany.
Martín Caballero L; Department of Physiological Chemistry, BioMedical Center (BMC), Ludwig-Maximillians-Universität München, Planegg-Martinsried, Germany.; International Max Planck Research School for Molecular and Cellular Life Sciences, Planegg-Martinsried, Germany.
den Brave F; Max Planck Institute of Biochemistry, Molecular Cell Biology, Planegg-Martinsried, Germany.; Institute for Biochemistry and Molecular Biology, University of Bonn, Bonn, Germany.
Pfander B; International Max Planck Research School for Molecular and Cellular Life Sciences, Planegg-Martinsried, Germany.; Max Planck Institute of Biochemistry, DNA Replication and Genome Integrity, Planegg-Martinsried, Germany.
Ladurner AG; Department of Physiological Chemistry, BioMedical Center (BMC), Ludwig-Maximillians-Universität München, Planegg-Martinsried, Germany.; International Max Planck Research School for Molecular and Cellular Life Sciences, Planegg-Martinsried, Germany.
Jentsch S; Max Planck Institute of Biochemistry, Molecular Cell Biology, Planegg-Martinsried, Germany.
Braun S; Department of Physiological Chemistry, BioMedical Center (BMC), Ludwig-Maximillians-Universität München, Planegg-Martinsried, Germany. .; International Max Planck Research School for Molecular and Cellular Life Sciences, Planegg-Martinsried, Germany. .; Institute for Genetics, Justus-Liebig University Giessen, Giessen, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 13; Vol. 12 (1), pp. 4918. Date of Electronic Publication: 2021 Aug 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair*
Cell Nucleolus/*genetics
DNA, Ribosomal/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Small Ubiquitin-Related Modifier Proteins/*genetics
Valosin Containing Protein/*genetics
Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Nucleolus/metabolism ; DNA Damage ; DNA, Ribosomal/metabolism ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mutation ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Phosphorylation ; Protein Binding ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Sumoylation ; Two-Hybrid System Techniques ; Valosin Containing Protein/metabolism
Czasopismo naukowe
Tytuł :
Intrinsic and extrinsic factors that may influence DNA preservation in skeletal remains: A review.
Autorzy :
Raffone C; BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain; Department of Physical Anthropology, Society of Sciences Aranzadi, Donostia-San Sebastian, Spain.
Baeta M; BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.
Lambacher N; Department of Physical Anthropology, Society of Sciences Aranzadi, Donostia-San Sebastian, Spain.
Granizo-Rodríguez E; BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.
Etxeberria F; Department of Legal Medicine, University of the Basque Country (UPV/EHU), Donostia-San Sebastian, Spain.
de Pancorbo MM; BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain. Electronic address: .
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Źródło :
Forensic science international [Forensic Sci Int] 2021 Aug; Vol. 325, pp. 110859. Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Body Remains*
DNA Degradation, Necrotic*
Postmortem Changes*
DNA/*analysis
Bone Density ; Bone and Bones/chemistry ; Bone and Bones/pathology ; Collagen/metabolism ; DNA Fingerprinting ; Forensic Medicine ; Groundwater ; Humans ; Humidity ; Hydrogen-Ion Concentration ; Soil/chemistry ; Soil Microbiology ; Temperature ; Tooth/chemistry ; Tooth/pathology
Czasopismo naukowe
Tytuł :
Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices.
Autorzy :
Ihle M; Department of Obstetrics and Gynecology, Ulm University, Ulm 89075, Germany.
Biber S; Department of Obstetrics and Gynecology, Ulm University, Ulm 89075, Germany.
Schroeder IS; Department of Biophysics, GSI Helmholtz Center for Heavy Ion Research, Darmstadt 64291, Germany.
Blattner C; Institute for Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Karlsruhe 76021, Germany.
Deniz M; Department of Obstetrics and Gynecology, Ulm University, Ulm 89075, Germany.
Damia G; Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri-IRCCS Milan, Milan 20156, Italy.
Gottifredi V; Cell cycle and Genomic Stability Laboratory, Fundación Instituto Leloir, Buenos Aires C1405BWE, Argentina.
Wiesmüller L; Department of Obstetrics and Gynecology, Ulm University, Ulm 89075, Germany.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jul 21; Vol. 49 (13), pp. 7457-7475.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Replication*
DNA-Directed DNA Polymerase/*metabolism
Stem Cells/*metabolism
Tumor Suppressor Protein p53/*metabolism
Cell Differentiation/genetics ; Cells, Cultured ; DNA Helicases/metabolism ; Embryonic Stem Cells/metabolism ; Humans ; Neoplastic Stem Cells/metabolism ; Stress, Physiological/genetics
Czasopismo naukowe
Tytuł :
Endonuclease enrichment TAPS for cost-effective genome-wide base-resolution DNA methylation detection.
Autorzy :
Cheng J; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Siejka-Zielińska P; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Liu Y; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Chandran A; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Kriaucionis S; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Song CX; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jul 21; Vol. 49 (13), pp. e76.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
Sequence Analysis, DNA/*methods
Animals ; Cells, Cultured ; Cost-Benefit Analysis ; CpG Islands ; Deoxyribonuclease (Pyrimidine Dimer) ; Embryonic Stem Cells/metabolism ; Genomics/methods ; Mice ; Sequence Analysis, DNA/economics ; Uracil-DNA Glycosidase
Czasopismo naukowe
Tytuł :
Development of a multiplex methylation-sensitive restriction enzyme-based SNP typing system for deconvolution of semen-containing mixtures.
Autorzy :
Li Z; School of Forensic Medicine, Shanxi Medical University, Jinzhong, Shanxi, 030619, People's Republic of China.
Li J; School of Forensic Medicine, Shanxi Medical University, Jinzhong, Shanxi, 030619, People's Republic of China.
Li Y; School of Forensic Medicine, Shanxi Medical University, Jinzhong, Shanxi, 030619, People's Republic of China.
Liu N; School of Forensic Medicine, Shanxi Medical University, Jinzhong, Shanxi, 030619, People's Republic of China.
Liu F; School of Forensic Medicine, Shanxi Medical University, Jinzhong, Shanxi, 030619, People's Republic of China.
Ren J; School of Forensic Medicine, Shanxi Medical University, Jinzhong, Shanxi, 030619, People's Republic of China.
Yun K; School of Forensic Medicine, Shanxi Medical University, Jinzhong, Shanxi, 030619, People's Republic of China. .
Yan J; School of Forensic Medicine, Shanxi Medical University, Jinzhong, Shanxi, 030619, People's Republic of China. .
Zhang G; School of Forensic Medicine, Shanxi Medical University, Jinzhong, Shanxi, 030619, People's Republic of China. .
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Źródło :
International journal of legal medicine [Int J Legal Med] 2021 Jul; Vol. 135 (4), pp. 1281-1294. Date of Electronic Publication: 2021 Apr 04.
Typ publikacji :
Journal Article
MeSH Terms :
CpG Islands*
DNA Methylation*
Polymorphism, Single Nucleotide*
DNA/*analysis
Restriction Mapping/*methods
Semen/*chemistry
Adult ; Asian Continental Ancestry Group/genetics ; Biomarkers ; Body Fluids/chemistry ; DNA Restriction Enzymes ; Electrophoresis, Capillary ; Female ; Forensic Genetics/methods ; Genetic Markers ; Humans ; Male ; Middle Aged ; Multiplex Polymerase Chain Reaction/methods ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells.
Autorzy :
Suzuki T; Division of Genetics and Mutagenesis, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan. Electronic address: .
Sassa A; Division of Genetics and Mutagenesis, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan.
Grúz P; Division of Genetics and Mutagenesis, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan.
Gupta RC; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York, 11794-3400, NY, United States.
Johnson F; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York, 11794-3400, NY, United States.
Adachi N; Graduate School of Nanobioscience, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama, Kanagawa, 236-0027, Japan.
Nohmi T; Division of Genetics and Mutagenesis, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan.
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Źródło :
DNA repair [DNA Repair (Amst)] 2021 Apr; Vol. 100, pp. 103052. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Catalytic Domain*
DNA Repair*
DNA Replication*
Mutation*
Benzo(a)pyrene/*metabolism
DNA Adducts/*metabolism
DNA-Binding Proteins/*genetics
DNA-Directed DNA Polymerase/*genetics
Cell Line ; DNA/metabolism ; DNA-Binding Proteins/metabolism ; DNA-Directed DNA Polymerase/metabolism ; Humans
Czasopismo naukowe
Tytuł :
Cryo-EM structure of TFIIH/Rad4-Rad23-Rad33 in damaged DNA opening in nucleotide excision repair.
Autorzy :
van Eeuwen T; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Center for Genome Integrity, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Shim Y; Department of Chemistry and Biochemistry, Baylor University, Waco, TX, USA.
Kim HJ; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Center for Genome Integrity, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Epigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Zhao T; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
Basu S; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
Garcia BA; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Epigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kaplan CD; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
Min JH; Department of Chemistry and Biochemistry, Baylor University, Waco, TX, USA. .
Murakami K; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. .; Penn Center for Genome Integrity, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 07; Vol. 12 (1), pp. 3338. Date of Electronic Publication: 2021 Jun 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cryoelectron Microscopy*
DNA Damage*
DNA Repair*
DNA/*chemistry
DNA-Binding Proteins/*chemistry
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*chemistry
Transcription Factor TFIIH/*chemistry
DNA Adducts/metabolism ; DNA Helicases/chemistry ; DNA Helicases/genetics ; DNA-Binding Proteins/genetics ; Saccharomyces cerevisiae Proteins/genetics ; Transcription Factor TFIIH/genetics
Czasopismo naukowe
Tytuł :
Structural basis of long-range to short-range synaptic transition in NHEJ.
Autorzy :
Chen S; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.; Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, IL, USA.
Lee L; Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada.; Robson DNA Science Centre, Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada.
Naila T; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.; Department of Molecular Genetics & Microbiology, University of New Mexico, Albuquerque, NM, USA.; University of New Mexico Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM, USA.
Fishbain S; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Wang A; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Tomkinson AE; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.; Department of Molecular Genetics & Microbiology, University of New Mexico, Albuquerque, NM, USA.; University of New Mexico Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM, USA.
Lees-Miller SP; Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada.; Robson DNA Science Centre, Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada.
He Y; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA. .; Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, IL, USA. .; Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA. .; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Northwestern University, Chicago, IL, USA. .
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Źródło :
Nature [Nature] 2021 May; Vol. 593 (7858), pp. 294-298. Date of Electronic Publication: 2021 Apr 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cryoelectron Microscopy*
DNA Breaks, Double-Stranded*
DNA End-Joining Repair*
DNA/*metabolism
DNA/*ultrastructure
DNA/chemistry ; DNA Ligase ATP/metabolism ; DNA Ligase ATP/ultrastructure ; DNA Repair Enzymes/metabolism ; DNA Repair Enzymes/ultrastructure ; DNA-Activated Protein Kinase/metabolism ; DNA-Activated Protein Kinase/ultrastructure ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/ultrastructure ; Humans ; Ku Autoantigen/metabolism ; Ku Autoantigen/ultrastructure ; Models, Molecular ; Phosphorylation
Czasopismo naukowe
Tytuł :
The N-terminal domain of uracil-DNA glycosylase: Roles for disordered regions.
Autorzy :
Perkins JL; Department of Chemistry and Environmental Toxicology Graduate Program, University of California, Riverside, Riverside, CA 92521, United States.
Zhao L; Department of Chemistry and Environmental Toxicology Graduate Program, University of California, Riverside, Riverside, CA 92521, United States. Electronic address: .
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Źródło :
DNA repair [DNA Repair (Amst)] 2021 May; Vol. 101, pp. 103077. Date of Electronic Publication: 2021 Feb 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
DNA Repair*
Protein Domains*
Uracil-DNA Glycosidase/*metabolism
Animals ; DNA/metabolism ; DNA Damage ; Humans ; Protein Binding ; Protein Isoforms ; Protein Processing, Post-Translational
Czasopismo naukowe
Tytuł :
TET-TDG Active DNA Demethylation at CpG and Non-CpG Sites.
Autorzy :
DeNizio JE; Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, Philadelphia, PA 19147, USA; Department of Medicine, Department of Biochemistry & Biophysics, Perelman School of Medicine, Philadelphia, PA 19147, USA.
Dow BJ; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Serrano JC; Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, Philadelphia, PA 19147, USA; Department of Medicine, Department of Biochemistry & Biophysics, Perelman School of Medicine, Philadelphia, PA 19147, USA.
Ghanty U; Department of Medicine, Department of Biochemistry & Biophysics, Perelman School of Medicine, Philadelphia, PA 19147, USA.
Drohat AC; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: .
Kohli RM; Department of Medicine, Department of Biochemistry & Biophysics, Perelman School of Medicine, Philadelphia, PA 19147, USA. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Apr 16; Vol. 433 (8), pp. 166877. Date of Electronic Publication: 2021 Feb 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
CpG Islands*
DNA Demethylation*
Thymine DNA Glycosylase/*chemistry
Thymine DNA Glycosylase/*metabolism
5-Methylcytosine/analogs & derivatives ; Cytosine/analogs & derivatives ; DNA Repair ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/metabolism ; Epigenesis, Genetic ; Humans ; Oxidation-Reduction ; Proto-Oncogene Proteins/chemistry ; Proto-Oncogene Proteins/metabolism ; Thymine DNA Glycosylase/genetics
Czasopismo naukowe

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