Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Zmień bibliotekę

Wyszukujesz frazę ""Drug Evaluation, Preclinical"" wg kryterium: Temat


Tytuł :
Construction of a Noninfectious SARS-CoV-2 Replicon for Antiviral-Drug Testing and Gene Function Studies.
Autorzy :
Nguyen HT; Vaccine and Infectious Disease Organization, University of Saskatchewangrid.25152.31, Saskatoon, Saskatchewan, Canada.
Falzarano D; Vaccine and Infectious Disease Organization, University of Saskatchewangrid.25152.31, Saskatoon, Saskatchewan, Canada.; Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewangrid.25152.31, Saskatoon, Saskatchewan, Canada.
Gerdts V; Vaccine and Infectious Disease Organization, University of Saskatchewangrid.25152.31, Saskatoon, Saskatchewan, Canada.; Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewangrid.25152.31, Saskatoon, Saskatchewan, Canada.
Liu Q; Vaccine and Infectious Disease Organization, University of Saskatchewangrid.25152.31, Saskatoon, Saskatchewan, Canada.; Vaccinology and Immunotherapeutics, School of Public Health, University of Saskatchewangrid.25152.31, Saskatoon, Saskatchewan, Canada.; Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewangrid.25152.31, Saskatoon, Saskatchewan, Canada.
Pokaż więcej
Źródło :
Journal of virology [J Virol] 2021 Aug 25; Vol. 95 (18), pp. e0068721. Date of Electronic Publication: 2021 Aug 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Evaluation, Preclinical*
Replicon*
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Green Fluorescent Proteins/*metabolism
SARS-CoV-2/*drug effects
Virus Replication/*drug effects
Animals ; COVID-19/virology ; Chlorocebus aethiops ; Green Fluorescent Proteins/genetics ; HEK293 Cells ; High-Throughput Screening Assays ; Humans
Czasopismo naukowe
Tytuł :
A computational study of cooperative binding to multiple SARS-CoV-2 proteins.
Autorzy :
Li J; Department of Chemistry, University of Vermont, Burlington, VT, 05405, USA. .
McKay KT; Department of Chemistry, University of Vermont, Burlington, VT, 05405, USA.
Remington JM; Department of Chemistry, University of Vermont, Burlington, VT, 05405, USA.
Schneebeli ST; Department of Chemistry, University of Vermont, Burlington, VT, 05405, USA.
Pokaż więcej
Źródło :
Scientific reports [Sci Rep] 2021 Aug 11; Vol. 11 (1), pp. 16307. Date of Electronic Publication: 2021 Aug 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Drug Evaluation, Preclinical*
Medicine, Chinese Traditional*
Antiviral Agents/*pharmacology
Drugs, Chinese Herbal/*pharmacology
SARS-CoV-2/*drug effects
Viral Proteins/*metabolism
Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; Cats ; Computational Biology ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/metabolism ; Flavonoids/metabolism ; Humans ; Molecular Dynamics Simulation ; Protein Binding ; RNA-Dependent RNA Polymerase/metabolism ; Spike Glycoprotein, Coronavirus/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase.
Autorzy :
Basu S; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Mak T; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Ulferts R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Wu M; High Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Deegan T; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Fujisawa R; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Tan KW; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Lim CT; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Basier C; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Canal B; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Curran JF; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Drury LS; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
McClure AW; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Roberts EL; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Weissmann F; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Zeisner TU; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Beale R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Cowling VH; Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Howell M; High Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Labib K; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Diffley JFX; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Pokaż więcej
Źródło :
The Biochemical journal [Biochem J] 2021 Jul 16; Vol. 478 (13), pp. 2481-2497.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Evaluation, Preclinical*
Antiviral Agents/*pharmacology
Exoribonucleases/*antagonists & inhibitors
Methyltransferases/*antagonists & inhibitors
RNA Caps/*metabolism
SARS-CoV-2/*enzymology
Small Molecule Libraries/*pharmacology
Viral Nonstructural Proteins/*antagonists & inhibitors
Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/pharmacology ; Alanine/analogs & derivatives ; Alanine/pharmacology ; Animals ; Antiviral Agents/chemistry ; Chlorobenzenes/pharmacology ; Chlorocebus aethiops ; Enzyme Assays ; Exoribonucleases/genetics ; Exoribonucleases/isolation & purification ; Exoribonucleases/metabolism ; Fluorescence Resonance Energy Transfer ; High-Throughput Screening Assays ; Indazoles/pharmacology ; Indenes/pharmacology ; Indoles/pharmacology ; Methyltransferases/genetics ; Methyltransferases/isolation & purification ; Methyltransferases/metabolism ; Nitriles/pharmacology ; Phenothiazines/pharmacology ; Purines/pharmacology ; Reproducibility of Results ; SARS-CoV-2/drug effects ; Small Molecule Libraries/chemistry ; Substrate Specificity ; Trifluperidol/pharmacology ; Vero Cells ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/isolation & purification ; Viral Nonstructural Proteins/metabolism ; Viral Regulatory and Accessory Proteins/genetics ; Viral Regulatory and Accessory Proteins/isolation & purification ; Viral Regulatory and Accessory Proteins/metabolism
Czasopismo naukowe
Tytuł :
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase.
Autorzy :
Bertolin AP; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Weissmann F; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Zeng J; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Posse V; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Milligan JC; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Canal B; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Ulferts R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Wu M; High Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Drury LS; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Howell M; High Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Beale R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Diffley JFX; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Pokaż więcej
Źródło :
The Biochemical journal [Biochem J] 2021 Jul 16; Vol. 478 (13), pp. 2425-2443.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Evaluation, Preclinical*
Antiviral Agents/*chemistry
Antiviral Agents/*pharmacology
Coronavirus RNA-Dependent RNA Polymerase/*antagonists & inhibitors
SARS-CoV-2/*enzymology
Small Molecule Libraries/*pharmacology
Animals ; Benzoates/pharmacology ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Chlorocebus aethiops ; Coronavirus RNA-Dependent RNA Polymerase/metabolism ; Enzyme Assays ; Fluorescence Resonance Energy Transfer ; High-Throughput Screening Assays ; Holoenzymes/metabolism ; Reproducibility of Results ; SARS-CoV-2/drug effects ; Small Molecule Libraries/chemistry ; Suramin/pharmacology ; Vero Cells ; Viral Nonstructural Proteins/antagonists & inhibitors ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Author's overview: identifying SARS-CoV-2 antiviral compounds.
Autorzy :
Diffley JFX; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Pokaż więcej
Źródło :
The Biochemical journal [Biochem J] 2021 Jul 16; Vol. 478 (13), pp. 2533-2535.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Evaluation, Preclinical*
Antiviral Agents/*chemistry
Antiviral Agents/*pharmacology
SARS-CoV-2/*enzymology
Small Molecule Libraries/*pharmacology
Viral Nonstructural Proteins/*antagonists & inhibitors
Animals ; Enzyme Assays ; Humans ; SARS-CoV-2/drug effects ; Small Molecule Libraries/chemistry ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease.
Autorzy :
Canal B; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Fujisawa R; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
McClure AW; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Deegan TD; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Wu M; High Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Ulferts R; Cell Biology of Infection Laboratory, the Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Weissmann F; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Drury LS; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Bertolin AP; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Zeng J; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Beale R; Cell Biology of Infection Laboratory, the Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Howell M; High Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Labib K; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Diffley JFX; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Pokaż więcej
Źródło :
The Biochemical journal [Biochem J] 2021 Jul 16; Vol. 478 (13), pp. 2465-2479.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Evaluation, Preclinical*
Antiviral Agents/*chemistry
Antiviral Agents/*pharmacology
Endoribonucleases/*antagonists & inhibitors
SARS-CoV-2/*enzymology
Small Molecule Libraries/*pharmacology
Viral Nonstructural Proteins/*antagonists & inhibitors
Allosteric Regulation ; Animals ; Chlorocebus aethiops ; Endoribonucleases/isolation & purification ; Endoribonucleases/metabolism ; Enzyme Assays ; Fluorescence ; High-Throughput Screening Assays ; In Vitro Techniques ; Kinetics ; Naphthoquinones/pharmacology ; Reproducibility of Results ; SARS-CoV-2/drug effects ; SARS-CoV-2/growth & development ; Small Molecule Libraries/chemistry ; Solutions ; Vero Cells ; Viral Nonstructural Proteins/isolation & purification ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease.
Autorzy :
Milligan JC; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Zeisner TU; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Papageorgiou G; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Joshi D; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Soudy C; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Ulferts R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Wu M; High Throughput Screening STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Lim CT; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Tan KW; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Weissmann F; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Canal B; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Fujisawa R; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Deegan T; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Nagaraj H; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Bineva-Todd G; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Basier C; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Curran JF; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Howell M; High Throughput Screening STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Beale R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Labib K; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
O'Reilly N; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Diffley JFX; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Pokaż więcej
Źródło :
The Biochemical journal [Biochem J] 2021 Jul 16; Vol. 478 (13), pp. 2499-2515.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Evaluation, Preclinical*
Antiviral Agents/*chemistry
Antiviral Agents/*pharmacology
Coronavirus 3C Proteases/*antagonists & inhibitors
SARS-CoV-2/*enzymology
Small Molecule Libraries/*pharmacology
Amino Acid Chloromethyl Ketones/pharmacology ; Animals ; Azoles/pharmacology ; Chlorocebus aethiops ; Coronavirus 3C Proteases/genetics ; Coronavirus 3C Proteases/isolation & purification ; Coronavirus 3C Proteases/metabolism ; Enzyme Assays ; Fluorescence Resonance Energy Transfer ; High-Throughput Screening Assays ; Leupeptins/pharmacology ; Organoselenium Compounds/pharmacology ; Peptidomimetics ; RNA-Binding Proteins/metabolism ; Reproducibility of Results ; SARS-CoV-2/drug effects ; Small Molecule Libraries/chemistry ; Vero Cells ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease.
Autorzy :
Lim CT; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Tan KW; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Wu M; High-Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Ulferts R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Armstrong LA; MRC Protein Phosphorylation & Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Ozono E; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Drury LS; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Milligan JC; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Zeisner TU; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Zeng J; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Weissmann F; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Canal B; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Bineva-Todd G; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Howell M; High-Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
O'Reilly N; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Beale R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Kulathu Y; MRC Protein Phosphorylation & Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Labib K; MRC Protein Phosphorylation & Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Diffley JFX; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Pokaż więcej
Źródło :
The Biochemical journal [Biochem J] 2021 Jul 16; Vol. 478 (13), pp. 2517-2531.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Drug Evaluation, Preclinical*
Antiviral Agents/*chemistry
Antiviral Agents/*pharmacology
Coronavirus Papain-Like Proteases/*antagonists & inhibitors
SARS-CoV-2/*enzymology
Small Molecule Libraries/*pharmacology
Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/pharmacology ; Alanine/analogs & derivatives ; Alanine/pharmacology ; Aniline Compounds/pharmacology ; Animals ; Benzamides/pharmacology ; Chlorocebus aethiops ; Coronavirus Papain-Like Proteases/genetics ; Coronavirus Papain-Like Proteases/isolation & purification ; Coronavirus Papain-Like Proteases/metabolism ; Drug Synergism ; Enzyme Assays ; Flavins/pharmacology ; Fluorescence Resonance Energy Transfer ; Furans/pharmacology ; High-Throughput Screening Assays ; Inhibitory Concentration 50 ; Naphthalenes/pharmacology ; Phenanthrenes/pharmacology ; Quinones/pharmacology ; Reproducibility of Results ; SARS-CoV-2/drug effects ; SARS-CoV-2/growth & development ; Small Molecule Libraries/chemistry ; Vero Cells ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase.
Autorzy :
Zeng J; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Weissmann F; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Bertolin AP; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Posse V; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Canal B; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Ulferts R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Wu M; High Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Harvey R; World Influenza Centre, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Hussain S; World Influenza Centre, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Milligan JC; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Roustan C; Structural Biology, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Borg A; Structural Biology, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
McCoy L; Division of Infection and Immunity, University College London, London WC1E 6BT, U.K.
Drury LS; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Kjaer S; Structural Biology, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
McCauley J; World Influenza Centre, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Howell M; High Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Beale R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Diffley JFX; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Pokaż więcej
Źródło :
The Biochemical journal [Biochem J] 2021 Jul 16; Vol. 478 (13), pp. 2405-2423.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Evaluation, Preclinical*
Antiviral Agents/*chemistry
Antiviral Agents/*pharmacology
RNA Helicases/*antagonists & inhibitors
SARS-CoV-2/*enzymology
Small Molecule Libraries/*pharmacology
Viral Nonstructural Proteins/*antagonists & inhibitors
Animals ; Chlorocebus aethiops ; Enzyme Assays ; Fluorescence Resonance Energy Transfer ; High-Throughput Screening Assays ; RNA Helicases/metabolism ; Reproducibility of Results ; SARS-CoV-2/drug effects ; Small Molecule Libraries/chemistry ; Suramin/pharmacology ; Vero Cells ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
An all-out assault on SARS-CoV-2 replication.
Autorzy :
Hay RT; Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Pokaż więcej
Źródło :
The Biochemical journal [Biochem J] 2021 Jul 16; Vol. 478 (13), pp. 2399-2403.
Typ publikacji :
Introductory Journal Article
MeSH Terms :
Drug Evaluation, Preclinical*
Antiviral Agents/*pharmacology
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
COVID-19/*virology
SARS-CoV-2/*drug effects
SARS-CoV-2/*growth & development
Virus Replication/*drug effects
Humans ; SARS-CoV-2/metabolism ; Viral Nonstructural Proteins/antagonists & inhibitors ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
DrugComb update: a more comprehensive drug sensitivity data repository and analysis portal.
Autorzy :
Zheng S; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki FI-00290, Finland.
Aldahdooh J; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki FI-00290, Finland.
Shadbahr T; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki FI-00290, Finland.
Wang Y; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki FI-00290, Finland.
Aldahdooh D; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki FI-00290, Finland.
Bao J; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki FI-00290, Finland.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FI-00290, Finland.
Wang W; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki FI-00290, Finland.
Tang J; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki FI-00290, Finland.
Pokaż więcej
Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jul 02; Vol. 49 (W1), pp. W174-W184.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Algorithms*
Databases, Factual*
Drug Evaluation, Preclinical*
Drug Therapy, Combination*
Internet*
COVID-19/drug therapy ; Data Visualization ; Datasets as Topic ; Drug Synergism ; Hemorrhagic Fever, Ebola/drug therapy ; Humans ; Machine Learning ; Malaria/drug therapy ; Neoplasms/drug therapy
Czasopismo naukowe
Tytuł :
Opinion on the Use of Animal Models in Nonclinical Safety Assessment: Pros and Cons.
Autorzy :
Sura R; 359181AbbVie, Inc., Preclinical Safety, North Chicago, IL, USA.
Hutt J; Greenfield Pathology Services, Inc., Greenfield, IN, USA.
Morgan S; StageBio, Castle Dr, Mason, OH, USA.
Pokaż więcej
Źródło :
Toxicologic pathology [Toxicol Pathol] 2021 Jul; Vol. 49 (5), pp. 990-995. Date of Electronic Publication: 2021 Apr 08.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Evaluation, Preclinical*
Animals ; Humans ; Models, Animal ; Risk Assessment
Czasopismo naukowe
Tytuł :
LUNAR :Drug Screening for Novel Coronavirus Based on Representation Learning Graph Convolutional Network.
Autorzy :
Zhou D
Peng S
Wei DQ
Zhong W
Dou Y
Xie X
Pokaż więcej
Źródło :
IEEE/ACM transactions on computational biology and bioinformatics [IEEE/ACM Trans Comput Biol Bioinform] 2021 Jul-Aug; Vol. 18 (4), pp. 1290-1298. Date of Electronic Publication: 2021 Aug 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neural Networks, Computer*
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
COVID-19/*virology
Drug Evaluation, Preclinical/*methods
SARS-CoV-2/*drug effects
COVID-19/epidemiology ; Computational Biology ; Databases, Pharmaceutical/statistics & numerical data ; Drug Development/methods ; Drug Development/statistics & numerical data ; Drug Evaluation, Preclinical/statistics & numerical data ; Drug Repositioning/methods ; Drug Repositioning/statistics & numerical data ; Host Microbial Interactions/drug effects ; Humans ; Nonlinear Dynamics ; Pandemics
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Drug Evaluation Based on a Multi-Channel Cell Chip with a Horizontal Co-Culture.
Autorzy :
Kim GJ; Department of Food and Nutrition, KC University, Seoul 07661, Korea.; Department of Biomedical Engineering, Sogang University, Seoul 04107, Korea.
Lee KJ; College of H-LAC, Daejeon University, Daejeon 34520, Korea.
Choi JW; Department of Biomedical Engineering, Sogang University, Seoul 04107, Korea.; Department of Chemical and Biomolecular Engineering, Sogang University, Seoul 04107, Korea.
An JH; Department of Food and Nutrition, KC University, Seoul 07661, Korea.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 29; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 29.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Culture Techniques*/instrumentation
Cell Culture Techniques*/methods
Drug Evaluation, Preclinical*/instrumentation
Drug Evaluation, Preclinical*/methods
Cell Line, Tumor ; Cell Proliferation ; Cell Size ; Coculture Techniques/instrumentation ; Coculture Techniques/methods ; HeLa Cells ; Humans ; Lab-On-A-Chip Devices ; Materials Testing ; Tissue Scaffolds/chemistry ; Toxicity Tests/instrumentation ; Toxicity Tests/methods
Czasopismo naukowe
Tytuł :
Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening.
Autorzy :
Ebisudani T; Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan; Department of Pulmonary Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
Sugimoto S; Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
Haga K; Laboratory of Viral Infection I, Department of Infection Control and Immunology, Ōmura Satoshi Memorial Institute & Graduate School of Infection Control Sciences, Kitasato University, Tokyo 108-8641, Japan.
Mitsuishi A; Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan; Department of Pulmonary Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
Takai-Todaka R; Laboratory of Viral Infection I, Department of Infection Control and Immunology, Ōmura Satoshi Memorial Institute & Graduate School of Infection Control Sciences, Kitasato University, Tokyo 108-8641, Japan.
Fujii M; Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
Toshimitsu K; Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
Hamamoto J; Department of Pulmonary Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
Sugihara K; Department of Pulmonary Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
Hishida T; Division of Thoracic Surgery, Keio University School of Medicine, Tokyo 160-8582, Japan.
Asamura H; Division of Thoracic Surgery, Keio University School of Medicine, Tokyo 160-8582, Japan.
Fukunaga K; Department of Pulmonary Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan; Coronavirus Task Force, Keio University School of Medicine, Tokyo 160-8582, Japan.
Yasuda H; Department of Pulmonary Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan. Electronic address: .
Katayama K; Laboratory of Viral Infection I, Department of Infection Control and Immunology, Ōmura Satoshi Memorial Institute & Graduate School of Infection Control Sciences, Kitasato University, Tokyo 108-8641, Japan; Coronavirus Task Force, Keio University School of Medicine, Tokyo 160-8582, Japan. Electronic address: .
Sato T; Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan; Coronavirus Task Force, Keio University School of Medicine, Tokyo 160-8582, Japan. Electronic address: .
Pokaż więcej
Źródło :
Cell reports [Cell Rep] 2021 Jun 08; Vol. 35 (10), pp. 109218. Date of Electronic Publication: 2021 May 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Evaluation, Preclinical*
Alveolar Epithelial Cells/*drug effects
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
SARS-CoV-2/*drug effects
Alveolar Epithelial Cells/metabolism ; Alveolar Epithelial Cells/virology ; Angiotensin-Converting Enzyme 2/metabolism ; COVID-19/metabolism ; COVID-19/virology ; Cells, Cultured ; Host-Pathogen Interactions ; Humans ; Proto-Oncogene Proteins c-akt/metabolism ; SARS-CoV-2/growth & development ; SARS-CoV-2/pathogenicity ; Spheroids, Cellular ; Time Factors ; Virus Replication/drug effects ; Wnt Signaling Pathway
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia.
Autorzy :
Braga L; King's College London, British Heart Foundation Centre of Research Excellence, School of Cardiovascular Medicine & Sciences, London, UK.
Ali H; King's College London, British Heart Foundation Centre of Research Excellence, School of Cardiovascular Medicine & Sciences, London, UK.
Secco I; King's College London, British Heart Foundation Centre of Research Excellence, School of Cardiovascular Medicine & Sciences, London, UK.
Chiavacci E; King's College London, British Heart Foundation Centre of Research Excellence, School of Cardiovascular Medicine & Sciences, London, UK.
Neves G; MRC Centre for Neurodevelopmental Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Goldhill D; Department of Infectious Diseases, Imperial College London, London, UK.
Penn R; Department of Infectious Diseases, Imperial College London, London, UK.
Jimenez-Guardeño JM; Department of Infectious Diseases, School of Immunology & Microbial Sciences, King's College London, London, UK.
Ortega-Prieto AM; Department of Infectious Diseases, School of Immunology & Microbial Sciences, King's College London, London, UK.
Bussani R; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Cannatà A; King's College London, British Heart Foundation Centre of Research Excellence, School of Cardiovascular Medicine & Sciences, London, UK.
Rizzari G; King's College London, British Heart Foundation Centre of Research Excellence, School of Cardiovascular Medicine & Sciences, London, UK.
Collesi C; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.; International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
Schneider E; King's College London, British Heart Foundation Centre of Research Excellence, School of Cardiovascular Medicine & Sciences, London, UK.; International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
Arosio D; Istituto di Biofisica (IBF), Consiglio Nazionale delle Ricerche (CNR), Trento, Italy.
Shah AM; King's College London, British Heart Foundation Centre of Research Excellence, School of Cardiovascular Medicine & Sciences, London, UK.
Barclay WS; Department of Infectious Diseases, Imperial College London, London, UK.
Malim MH; Department of Infectious Diseases, School of Immunology & Microbial Sciences, King's College London, London, UK.
Burrone J; MRC Centre for Neurodevelopmental Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Giacca M; King's College London, British Heart Foundation Centre of Research Excellence, School of Cardiovascular Medicine & Sciences, London, UK. .; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy. .; International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy. .
Pokaż więcej
Źródło :
Nature [Nature] 2021 Jun; Vol. 594 (7861), pp. 88-93. Date of Electronic Publication: 2021 Apr 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Fusion*
Drug Evaluation, Preclinical*
Anoctamins/*antagonists & inhibitors
COVID-19/*pathology
Giant Cells/*drug effects
SARS-CoV-2/*drug effects
Spike Glycoprotein, Coronavirus/*antagonists & inhibitors
Aged ; Aged, 80 and over ; Alveolar Epithelial Cells/drug effects ; Alveolar Epithelial Cells/pathology ; Alveolar Epithelial Cells/virology ; Animals ; Anoctamins/metabolism ; COVID-19/metabolism ; COVID-19/virology ; Calcium Signaling/drug effects ; Cell Line ; Chloride Channels/metabolism ; Chlorocebus aethiops ; Female ; Giant Cells/metabolism ; Giant Cells/virology ; Humans ; Lung/drug effects ; Lung/pathology ; Lung/virology ; Male ; SARS-CoV-2/metabolism ; SARS-CoV-2/pathogenicity ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Efficient Stable Cell Line Generation of Survivin as an In Vitro Model for Specific Functional Analysis in Apoptosis and Drug Screening.
Autorzy :
Houshdarpour R; Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Ataei F; Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran. .
Hosseinkhani S; Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Pokaż więcej
Źródło :
Molecular biotechnology [Mol Biotechnol] 2021 Jun; Vol. 63 (6), pp. 515-524. Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Evaluation, Preclinical*
Apoptosis/*genetics
Survivin/*genetics
Animals ; Cell Line ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Humans ; Imidazoles/pharmacology ; Mice ; Naphthoquinones/pharmacology ; Survivin/chemistry ; Survivin/pharmacology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
The Glitazone Class of Drugs as Carbonic Anhydrase Inhibitors-A Spin-Off Discovery from Fragment Screening.
Autorzy :
Mueller SL; Griffith Institute for Drug Discovery, Griffith University, Nathan, Brisbane, QLD 4111, Australia.; ARC Centre for Fragment-Based Design, Griffith University, Nathan, Brisbane, QLD 4111, Australia.; CSIRO, Biomedical Manufacturing Program, Parkville, Melbourne, VIC 3052, Australia.
Chrysanthopoulos PK; Griffith Institute for Drug Discovery, Griffith University, Nathan, Brisbane, QLD 4111, Australia.
Halili MA; Griffith Institute for Drug Discovery, Griffith University, Nathan, Brisbane, QLD 4111, Australia.; ARC Centre for Fragment-Based Design, Griffith University, Nathan, Brisbane, QLD 4111, Australia.
Hepburn C; Waters Australia Pty Ltd., Rydalmere, NSW 2116, Australia.
Nebl T; CSIRO, Biomedical Manufacturing Program, Parkville, Melbourne, VIC 3052, Australia.
Supuran CT; Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche Nutraceutiche, Università Degli Studi di Firenze, Sesto Fiorentino, 50019 Florence, Italy.
Nocentini A; Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche Nutraceutiche, Università Degli Studi di Firenze, Sesto Fiorentino, 50019 Florence, Italy.
Peat TS; CSIRO, Biomedical Manufacturing Program, Parkville, Melbourne, VIC 3052, Australia.
Poulsen SA; Griffith Institute for Drug Discovery, Griffith University, Nathan, Brisbane, QLD 4111, Australia.; ARC Centre for Fragment-Based Design, Griffith University, Nathan, Brisbane, QLD 4111, Australia.
Pokaż więcej
Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 May 18; Vol. 26 (10). Date of Electronic Publication: 2021 May 18.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Drug Evaluation, Preclinical*
Carbonic Anhydrase Inhibitors/*analysis
Carbonic Anhydrase Inhibitors/*pharmacology
Thiazolidinediones/*analysis
Thiazolidinediones/*pharmacology
Carbonic Anhydrase Inhibitors/chemistry ; Carbonic Anhydrases/chemistry ; Crystallography, X-Ray ; Humans ; Hydrogen Deuterium Exchange-Mass Spectrometry ; Models, Molecular ; Thiazolidinediones/chemistry
Czasopismo naukowe
Tytuł :
A Drug Screening Pipeline Using 2D and 3D Patient-Derived In Vitro Models for Pre-Clinical Analysis of Therapy Response in Glioblastoma.
Autorzy :
Lenin S; Centre for Cancer Biology, SA Pathology and the University of South of Australia, Adelaide, SA 5000, Australia.
Ponthier E; Centre for Cancer Biology, SA Pathology and the University of South of Australia, Adelaide, SA 5000, Australia.
Scheer KG; Centre for Cancer Biology, SA Pathology and the University of South of Australia, Adelaide, SA 5000, Australia.
Yeo ECF; Centre for Cancer Biology, SA Pathology and the University of South of Australia, Adelaide, SA 5000, Australia.
Tea MN; Centre for Cancer Biology, SA Pathology and the University of South of Australia, Adelaide, SA 5000, Australia.
Ebert LM; Centre for Cancer Biology, SA Pathology and the University of South of Australia, Adelaide, SA 5000, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.; Cancer Clinical Trials Unit, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Oksdath Mansilla M; Centre for Cancer Biology, SA Pathology and the University of South of Australia, Adelaide, SA 5000, Australia.
Poonnoose S; Flinders Health and Medical Research Institute, College of Medicine & Public Health, Flinders University, Adelaide, SA 5042, Australia.; Department of Neurosurgery, Flinders Medical Centre, Adelaide, SA 5042, Australia.
Baumgartner U; Cell and Molecular Biology Department, Sid Faithfull Brain Cancer Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.; Faculty of Health, Queensland University of Technology, Brisbane, QLD 4006, Australia.; Faculty of Medicine, University of Queensland, Brisbane, QLD 4072, Australia.
Day BW; Cell and Molecular Biology Department, Sid Faithfull Brain Cancer Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.; Faculty of Health, Queensland University of Technology, Brisbane, QLD 4006, Australia.; Faculty of Medicine, University of Queensland, Brisbane, QLD 4072, Australia.
Ormsby RJ; Flinders Health and Medical Research Institute, College of Medicine & Public Health, Flinders University, Adelaide, SA 5042, Australia.
Pitson SM; Centre for Cancer Biology, SA Pathology and the University of South of Australia, Adelaide, SA 5000, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.
Gomez GA; Centre for Cancer Biology, SA Pathology and the University of South of Australia, Adelaide, SA 5000, Australia.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 21; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 21.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Evaluation, Preclinical*
Organoids*
Antineoplastic Agents/*pharmacology
Brain Neoplasms/*drug therapy
Glioblastoma/*drug therapy
Antineoplastic Agents/therapeutic use ; Brain Neoplasms/physiopathology ; Cells, Cultured ; Glioblastoma/physiopathology ; Humans ; Precision Medicine ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
RNA-Targeting Splicing Modifiers: Drug Development and Screening Assays.
Autorzy :
Tang Z; Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66047, USA.
Zhao J; Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66047, USA.
Pearson ZJ; Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66047, USA.
Boskovic ZV; Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66047, USA.
Wang J; Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66047, USA.
Pokaż więcej
Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Apr 14; Vol. 26 (8). Date of Electronic Publication: 2021 Apr 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Development*
Drug Evaluation, Preclinical*
RNA Splicing/*genetics
Animals ; Base Sequence ; Disease/genetics ; Humans ; Small Molecule Libraries/pharmacology ; Spliceosomes/metabolism
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies