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Tytuł :
Biotechnological Production of Carotenoids Using Low Cost-Substrates Is Influenced by Cultivation Parameters: A Review.
Autorzy :
Igreja WS; Graduate Program in Food Science and Technology (PPGCTA), Institute of Technology (ITEC), Federal University of Pará (UFPA), Belém 66075-110, PA, Brazil.
Maia FA; Faculty of Food Engineering (FEA), Institute of Technology (ITEC), Federal University of Pará (UFPA), Belém 66075-110, PA, Brazil.
Lopes AS; Graduate Program in Food Science and Technology (PPGCTA), Institute of Technology (ITEC), Federal University of Pará (UFPA), Belém 66075-110, PA, Brazil.; Faculty of Food Engineering (FEA), Institute of Technology (ITEC), Federal University of Pará (UFPA), Belém 66075-110, PA, Brazil.
Chisté RC; Graduate Program in Food Science and Technology (PPGCTA), Institute of Technology (ITEC), Federal University of Pará (UFPA), Belém 66075-110, PA, Brazil.; Faculty of Food Engineering (FEA), Institute of Technology (ITEC), Federal University of Pará (UFPA), Belém 66075-110, PA, Brazil.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 17; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genetic Engineering*
Antioxidants/*metabolism
Biotechnology/*methods
Carotenoids/*metabolism
Animals ; Humans ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering.
Autorzy :
He L; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.
Tan P; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Zhu L; High Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China.
Huang K; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Worcester, MA, USA.
Nguyen NT; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.
Wang R; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.
Guo L; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.
Li L; High Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China.
Yang Y; Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, College of Medicine, Texas A&M University, Houston, TX, USA.
Huang Z; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.
Huang Y; Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, College of Medicine, Texas A&M University, Houston, TX, USA. .
Han G; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Worcester, MA, USA. .
Wang J; High Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China. .; Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui, China. .
Zhou Y; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA. .; Department of Translational Medical Sciences, College of Medicine, Texas A&M University, Houston, TX, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2021 Aug; Vol. 17 (8), pp. 915-923. Date of Electronic Publication: 2021 May 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Engineering*
Optogenetics*
Arabidopsis Proteins/*genetics
DNA-Binding Proteins/*genetics
Animals ; Arabidopsis Proteins/chemistry ; Arabidopsis Proteins/metabolism ; Cells, Cultured ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/metabolism ; Female ; Humans ; Mice ; Mice, Inbred NOD ; Mice, Transgenic ; Photochemical Processes
Czasopismo naukowe
Tytuł :
Engineering self-organized criticality in living cells.
Autorzy :
Vidiella B; ICREA-Complex Systems Lab, Universitat Pompeu Fabra, Barcelona, Spain.; Institut de Biologia Evolutiva (CSIC-UPF), Barcelona, Spain.
Guillamon A; Departament de Matemàtiques, EPSEB, Universitat Politècnica de Catalunya, Barcelona, Spain.; Institut de Matemàtiques de la UPC-BarcelonaTech (IMTech), Universitat Politècnica de Catalunya, Barcelona, Spain.; Centre de Recerca Matemàtica, Edifici C, Campus de Bellaterra, Barcelona, Spain.
Sardanyés J; Centre de Recerca Matemàtica, Edifici C, Campus de Bellaterra, Barcelona, Spain.
Maull V; ICREA-Complex Systems Lab, Universitat Pompeu Fabra, Barcelona, Spain.; Institut de Biologia Evolutiva (CSIC-UPF), Barcelona, Spain.
Pla J; ICREA-Complex Systems Lab, Universitat Pompeu Fabra, Barcelona, Spain.; Institut de Biologia Evolutiva (CSIC-UPF), Barcelona, Spain.
Conde N; ICREA-Complex Systems Lab, Universitat Pompeu Fabra, Barcelona, Spain. .; Institut de Biologia Evolutiva (CSIC-UPF), Barcelona, Spain. .
Solé R; ICREA-Complex Systems Lab, Universitat Pompeu Fabra, Barcelona, Spain. .; Institut de Biologia Evolutiva (CSIC-UPF), Barcelona, Spain. .; Santa Fe Institute, Santa Fe NM, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 20; Vol. 12 (1), pp. 4415. Date of Electronic Publication: 2021 Jul 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Bacterial*
Genetic Engineering*
Cell Engineering/*methods
Escherichia coli/*growth & development
Escherichia coli Proteins/*metabolism
Escherichia coli/genetics ; Escherichia coli/metabolism ; Escherichia coli Proteins/genetics ; Feedback, Physiological ; Models, Genetic ; Proteolysis ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
Engineering life in synthetic systems.
Autorzy :
Oriola D; EMBL Barcelona, Dr Aiguader 88, 08003 Barcelona, Spain.
Spagnoli FM; Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, Floor 28, Tower Wing, Great Maze Pond, London SE1 9RT, UK.
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Źródło :
Development (Cambridge, England) [Development] 2021 Jul 15; Vol. 148 (14). Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Developmental Biology*
Gene Regulatory Networks*
Genetic Engineering*
Morphogenesis/*genetics
Biological Evolution ; Humans ; Signal Transduction ; Synthetic Biology ; Systems Biology
Czasopismo naukowe
Tytuł :
High-throughput 5' UTR engineering for enhanced protein production in non-viral gene therapies.
Autorzy :
Cao J; Synthetic Biology Group, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Novoa EM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Center for Genomic Regulation (CRG), Barcelona, Spain.
Zhang Z; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Chen WCW; Synthetic Biology Group, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA, USA.
Liu D; Synthetic Biology Group, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Choi GCG; Synthetic Biology Group, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA, USA.; School of Biomedical Sciences, University of Hong Kong, Hong Kong, China.
Wong ASL; Synthetic Biology Group, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA, USA.; School of Biomedical Sciences, University of Hong Kong, Hong Kong, China.
Wehrspaun C; Synthetic Biology Group, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA, USA.
Kellis M; Broad Institute of MIT and Harvard, Cambridge, MA, USA. .; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA. .; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA. .
Lu TK; Synthetic Biology Group, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA. .; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. .; Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA, USA. .; Broad Institute of MIT and Harvard, Cambridge, MA, USA. .; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 06; Vol. 12 (1), pp. 4138. Date of Electronic Publication: 2021 Jul 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Genetic Engineering*
Genetic Therapy*
5' Untranslated Regions/*genetics
Algorithms ; Cell Line ; Gene Expression ; HEK293 Cells ; High-Throughput Screening Assays ; Humans ; Plasmids ; Promoter Regions, Genetic ; Recombinases
Czasopismo naukowe
Tytuł :
Emerging gene therapies for enhancing the hemostatic potential of platelets.
Autorzy :
Leung J; Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
Cau MF; Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada.; School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada.
Kastrup CJ; Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
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Źródło :
Transfusion [Transfusion] 2021 Jul; Vol. 61 Suppl 1, pp. S275-S285.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Genetic Engineering*/methods
Hemostasis*
Platelet Transfusion*/methods
Blood Platelets/*metabolism
Animals ; Blood Platelets/cytology ; Genetic Therapy/methods ; Humans ; Transfection
Czasopismo naukowe
Tytuł :
Predictable control of RNA lifetime using engineered degradation-tuning RNAs.
Autorzy :
Zhang Q; School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA.
Ma D; Biodesign Center for Molecular Design and Biomimetics, The Biodesign Institute and School of Molecular Sciences, Arizona State University, Tempe, AZ, USA.
Wu F; School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA.
Standage-Beier K; School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA.
Chen X; School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA.
Wu K; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; Molecular Biology, Cell Biology & Biochemistry Program, Graduate School of Arts and Sciences, Boston University, Boston, MA, USA.
Green AA; Department of Biomedical Engineering, Boston University, Boston, MA, USA. .; Molecular Biology, Cell Biology & Biochemistry Program, Graduate School of Arts and Sciences, Boston University, Boston, MA, USA. .
Wang X; School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2021 Jul; Vol. 17 (7), pp. 828-836. Date of Electronic Publication: 2021 Jun 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Genetic Engineering*
RNA/*genetics
Biotechnology ; Escherichia coli/genetics ; Escherichia coli/metabolism ; RNA/metabolism
Czasopismo naukowe
Tytuł :
Developing GDi-CRISPR System for Multi-copy Integration in Saccharomyces cerevisiae.
Autorzy :
Zhang ZX; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, 2 Xuelin Road, Qixia District, Nanjing, Jiangsu Province, China.
Wang YZ; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, 2 Xuelin Road, Qixia District, Nanjing, Jiangsu Province, China.
Xu YS; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, 2 Xuelin Road, Qixia District, Nanjing, Jiangsu Province, China.
Sun XM; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, 2 Xuelin Road, Qixia District, Nanjing, Jiangsu Province, China. .
Huang H; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, 2 Xuelin Road, Qixia District, Nanjing, Jiangsu Province, China.
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Źródło :
Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2021 Jul; Vol. 193 (7), pp. 2379-2388. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article
MeSH Terms :
CRISPR-Cas Systems*
Genetic Engineering*
Saccharomyces cerevisiae/*genetics
Recombinant Proteins/biosynthesis ; Recombinant Proteins/genetics ; Saccharomyces cerevisiae/metabolism
Czasopismo naukowe
Tytuł :
Nonviral genome engineering of natural killer cells.
Autorzy :
Robbins GM; Department of Pediatrics, University of Minnesota, Minneapolis, MN, 55455, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, 55455, USA.; Center for Genome Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.; College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, 55455, USA.
Wang M; Department of Pediatrics, University of Minnesota, Minneapolis, MN, 55455, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, 55455, USA.; Center for Genome Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.
Pomeroy EJ; Department of Pediatrics, University of Minnesota, Minneapolis, MN, 55455, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, 55455, USA.; Center for Genome Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.
Moriarity BS; Department of Pediatrics, University of Minnesota, Minneapolis, MN, 55455, USA. .; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, 55455, USA. .; Center for Genome Engineering, University of Minnesota, Minneapolis, MN, 55455, USA. .
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Źródło :
Stem cell research & therapy [Stem Cell Res Ther] 2021 Jun 16; Vol. 12 (1), pp. 350. Date of Electronic Publication: 2021 Jun 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genetic Engineering*
Neoplasms*/genetics
Neoplasms*/therapy
Humans ; Immunotherapy ; Immunotherapy, Adoptive ; Killer Cells, Natural ; Receptors, Antigen, T-Cell/genetics ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Genetic Engineering in Combination with Semi-Synthesis Leads to a New Route for Gram-Scale Production of the Immunosuppressive Natural Product Brasilicardin A.
Autorzy :
Botas A; Departamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo and Instituto de Investigación Sanitaria de Asturias (ISPA), c/ Julián Clavería s/n., 33006, Oviedo, Spain.
Eitel M; Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, University of Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany.
Schwarz PN; Department of Microbiology and Biotechnology, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Auf der Morgenstelle 28, 72076, Tübingen, Germany.
Buchmann A; Department of Pharmaceutical Biology, Institute of Pharmaceutical Sciences, University of Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany.
Costales P; EntreChem S.L., Vivero Ciencias de la Salud, c/ Colegio Santo Domingo de Guzmán, s/n, 33011, Oviedo, Spain.
Núñez LE; EntreChem S.L., Vivero Ciencias de la Salud, c/ Colegio Santo Domingo de Guzmán, s/n, 33011, Oviedo, Spain.
Cortés J; EntreChem S.L., Vivero Ciencias de la Salud, c/ Colegio Santo Domingo de Guzmán, s/n, 33011, Oviedo, Spain.
Morís F; EntreChem S.L., Vivero Ciencias de la Salud, c/ Colegio Santo Domingo de Guzmán, s/n, 33011, Oviedo, Spain.
Krawiec M; Department of Molecular Microbiology, Faculty of Biotechnology, University of Wrocław, ul. F. Joliot-Curie 14A, 50-383, Wrocław, Poland.
Wolański M; Department of Molecular Microbiology, Faculty of Biotechnology, University of Wrocław, ul. F. Joliot-Curie 14A, 50-383, Wrocław, Poland.
Gust B; Department of Pharmaceutical Biology, Institute of Pharmaceutical Sciences, University of Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany.
Rodriguez M; Quadriga BioSciences, Inc., 339 S. San Antonio Road, Suite 2A, Los Altos, CA, 94022, USA.
Fischer WN; Quadriga BioSciences, Inc., 339 S. San Antonio Road, Suite 2A, Los Altos, CA, 94022, USA.
Jandeleit B; Quadriga BioSciences, Inc., 339 S. San Antonio Road, Suite 2A, Los Altos, CA, 94022, USA.
Zakrzewska-Czerwińska J; Department of Molecular Microbiology, Faculty of Biotechnology, University of Wrocław, ul. F. Joliot-Curie 14A, 50-383, Wrocław, Poland.
Wohlleben W; Department of Microbiology and Biotechnology, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Auf der Morgenstelle 28, 72076, Tübingen, Germany.
Stegmann E; Department of Microbiology and Biotechnology, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Auf der Morgenstelle 28, 72076, Tübingen, Germany.
Koch P; Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, University of Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany.
Méndez C; Departamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo and Instituto de Investigación Sanitaria de Asturias (ISPA), c/ Julián Clavería s/n., 33006, Oviedo, Spain.
Gross H; Department of Pharmaceutical Biology, Institute of Pharmaceutical Sciences, University of Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Jun 07; Vol. 60 (24), pp. 13536-13541. Date of Electronic Publication: 2021 May 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Engineering*
Aminoglycosides/*metabolism
Immunosuppressive Agents/*chemical synthesis
Alkyl and Aryl Transferases/genetics ; Aminoglycosides/chemical synthesis ; Aminoglycosides/chemistry ; Aminoglycosides/pharmacology ; Animals ; Biological Products/chemical synthesis ; Biological Products/chemistry ; Biological Products/metabolism ; Biological Products/pharmacology ; Cell Line ; Cell Survival/drug effects ; Humans ; Immunosuppressive Agents/chemistry ; Immunosuppressive Agents/metabolism ; Immunosuppressive Agents/pharmacology ; Mice ; Plasmids/genetics ; Plasmids/metabolism ; Streptomyces/genetics ; Streptomyces/metabolism ; Terpenes/chemistry
Czasopismo naukowe
Tytuł :
Development of Group B Coxsackievirus as an Oncolytic Virus: Opportunities and Challenges.
Autorzy :
Liu H; Centre for Heart Lung Innovation, St. Paul's Hospital-University of British Columbia, Vancouver, BC V6Z 1Y6, Canada.; Department of Experimental Medicine, University of British Columbia, Vancouver, BC V6Z 1Y6, Canada.
Luo H; Centre for Heart Lung Innovation, St. Paul's Hospital-University of British Columbia, Vancouver, BC V6Z 1Y6, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6Z 1Y6, Canada.
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Źródło :
Viruses [Viruses] 2021 Jun 05; Vol. 13 (6). Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Engineering*/methods
Enterovirus B, Human/*genetics
Genetic Vectors/*genetics
Oncolytic Viruses/*genetics
Animals ; Clinical Trials as Topic ; Drug Evaluation, Preclinical ; Enterovirus B, Human/physiology ; Genetic Therapy/adverse effects ; Genetic Therapy/methods ; Humans ; Neoplasms/therapy ; Oncolytic Virotherapy/adverse effects ; Oncolytic Virotherapy/methods ; Treatment Outcome ; Virus Replication
Czasopismo naukowe
Tytuł :
Therapeutic and diagnostic relevance of Crispr technology.
Autorzy :
El Ouar I; University Frères Mentouri Constantine, 1. Road Ain El Bey, Constantine 25000, Algeria. Electronic address: .
Djekoun A; University Frères Mentouri Constantine, 1. Road Ain El Bey, Constantine 25000, Algeria.
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jun; Vol. 138, pp. 111487. Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
CRISPR-Cas Systems/*physiology
Clustered Regularly Interspaced Short Palindromic Repeats/*physiology
Gene Editing/*methods
Genetic Engineering/*methods
Genetic Therapy/*methods
Animals ; Gene Editing/trends ; Genetic Engineering/trends ; Genetic Therapy/trends ; Humans
Czasopismo naukowe
Tytuł :
Industrializing engineered autologous T cells as medicines for solid tumours.
Autorzy :
Britten CM; Oncology R&D, GlaxoSmithKline, Stevenage, UK.; Immatics Biotechnologies, Munich, Germany.
Shalabi A; Oncology R&D, GlaxoSmithKline, Philadelphia, PA, USA.
Hoos A; Oncology R&D, GlaxoSmithKline, Philadelphia, PA, USA. .
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Źródło :
Nature reviews. Drug discovery [Nat Rev Drug Discov] 2021 Jun; Vol. 20 (6), pp. 476-488. Date of Electronic Publication: 2021 Apr 08.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genetic Engineering*
Cell- and Tissue-Based Therapy/*methods
Immunotherapy, Adoptive/*methods
Neoplasms/*therapy
Receptors, Chimeric Antigen/*immunology
T-Lymphocytes/*immunology
Animals ; Humans ; Neoplasms/immunology ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Novel S. cerevisiae Hybrid Synthetic Promoters Based on Foreign Core Promoter Sequences.
Autorzy :
Feng X; School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Tianjin 300072, China.
Marchisio MA; School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Tianjin 300072, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 27; Vol. 22 (11). Date of Electronic Publication: 2021 May 27.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Engineering*
Promoter Regions, Genetic*
Saccharomyces cerevisiae/*genetics
5' Untranslated Regions ; Base Sequence ; Gene Expression Regulation, Fungal ; Genes, Reporter ; Mutation ; TATA Box ; Transcription Initiation Site
Czasopismo naukowe
Tytuł :
Engineering circular RNA regulators to specifically promote circular RNA production.
Autorzy :
Qi Y; Second Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China 116044.
Han W; Second Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China 116044.
Chen D; Department of Pathology, First Affiliated Hospital, Dalian Medical University, Dalian, China 116044.
Zhao J; Second Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China 116044.
Bai L; Second Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China 116044.
Huang F; Second Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China 116044.
Dai Z; Second Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China 116044.
Li G; Second Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China 116044.
Chen C; Second Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China 116044.
Zhang W; Second Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China 116044.
Zhang J; Second Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China 116044.
Jin B; Second Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China 116044.
Wang Y; Second Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China 116044.
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Źródło :
Theranostics [Theranostics] 2021 May 24; Vol. 11 (15), pp. 7322-7336. Date of Electronic Publication: 2021 May 24 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Genetic Engineering*
Nucleotide Motifs*
RNA, Circular*/biosynthesis
RNA, Circular*/genetics
RNA-Binding Proteins*/biosynthesis
RNA-Binding Proteins*/genetics
Transcription Factors*/biosynthesis
Transcription Factors*/genetics
HEK293 Cells ; HeLa Cells ; Humans
Czasopismo naukowe
Tytuł :
Contemporary Transposon Tools: A Review and Guide through Mechanisms and Applications of Sleeping Beauty , piggyBac and Tol2 for Genome Engineering.
Autorzy :
Sandoval-Villegas N; Division of Medical Biotechnology, Paul Ehrlich Institute, 63225 Langen, Germany.
Nurieva W; Division of Medical Biotechnology, Paul Ehrlich Institute, 63225 Langen, Germany.
Amberger M; Division of Medical Biotechnology, Paul Ehrlich Institute, 63225 Langen, Germany.
Ivics Z; Division of Medical Biotechnology, Paul Ehrlich Institute, 63225 Langen, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 11; Vol. 22 (10). Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
DNA Transposable Elements*
Genetic Engineering*
Genetic Vectors*
Genome*
DNA-Binding Proteins/*metabolism
Transposases/*metabolism
Animals ; Animals, Genetically Modified ; DNA-Binding Proteins/genetics ; Humans ; Transposases/genetics
Czasopismo naukowe
Tytuł :
Engineering three-dimensional genome folding.
Autorzy :
Zhang D; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lam J; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Blobel GA; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. .; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. .
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Źródło :
Nature genetics [Nat Genet] 2021 May; Vol. 53 (5), pp. 602-611. Date of Electronic Publication: 2021 May 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Genetic Engineering*
Genome*
Nucleic Acid Conformation*
Animals ; Chromatin/chemistry ; DNA Transposable Elements/genetics ; Evolution, Molecular ; Humans
Czasopismo naukowe
Tytuł :
Golden Gate vectors for efficient gene fusion and gene deletion in diverse filamentous fungi.
Autorzy :
Dahlmann TA; Allgemeine und Molekulare Botanik, Ruhr-Universität Bochum, Universitätsstrasse 150, 44801, Bochum, Germany.
Terfehr D; Allgemeine und Molekulare Botanik, Ruhr-Universität Bochum, Universitätsstrasse 150, 44801, Bochum, Germany.
Becker K; Allgemeine und Molekulare Botanik, Ruhr-Universität Bochum, Universitätsstrasse 150, 44801, Bochum, Germany.
Teichert I; Allgemeine und Molekulare Botanik, Ruhr-Universität Bochum, Universitätsstrasse 150, 44801, Bochum, Germany. .
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Źródło :
Current genetics [Curr Genet] 2021 Apr; Vol. 67 (2), pp. 317-330. Date of Electronic Publication: 2020 Dec 24.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Deletion*
Genetic Engineering*
Cloning, Molecular/*methods
Gene Fusion/*genetics
Fungi/genetics ; Genetic Vectors ; Plasmids/genetics ; Sordariales/genetics
SCR Organism :
Sordaria macrospora
Czasopismo naukowe

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