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Tytuł :
Development and Validation of a Polygenic Risk Score for Stroke in the Chinese Population.
Autorzy :
Lu X; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor. .
Niu X; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Shen C; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Liu F; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Liu Z; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Huang K; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Wang L; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Li J; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Hu D; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Zhao Y; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Yang X; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Lu F; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor. .
Liu X; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Cao J; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Chen S; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Li H; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Tang W; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Ren Z; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Yu L; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Wu X; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Wu X; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Li Y; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Zhang H; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Huang J; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Hu Z; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Shen H; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Willer CJ; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
Gu D; From the Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology (Xiangfeng Lu, X.N., Fangchao Liu, Z.L., K.H., L.W., J.L., J.C., S.C., H.L., Xigui Wu, Y.L., J.H., D.G.), State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Department of Epidemiology and Biostatistics (C.S., Z.H., H.S.), Center for Global Health, School of Public Health, Nanjing Medical University; Department of Biostatistics and Epidemiology (D.H.), School of Public Health, Shenzhen University Health Science Center, Guangdong; Cardio-Cerebrovascular Control and Research Center (Y.Z., Fanghong Lu), Institute of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan; Tianjin Key Laboratory of Environment, Nutrition and Public Health (X.Y.), Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; Division of Epidemiology (Xiaoqing Liu), Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; Department of Neurology (W.T., Z.R.), Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing; Department of Cardiology (L.Y.), Fujian Provincial Hospital, Fuzhou; Center for Chronic and Noncommunicable Disease Control and Prevention (Xianping Wu), Sichuan Center for Disease Control and Prevention, Chengdu; Center for Genetic Epidemiology and Genomics (H.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer (H.S.), Chinese Academy of Medical Sciences (2019RU038); and Department of Internal Medicine, Division of Cardiovascular Medicine (C.J.W.), and Department of Human Genetics (C.J.W.), University of Michigan, Ann Arbor.
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Źródło :
Neurology [Neurology] 2021 Aug 10; Vol. 97 (6), pp. e619-e628. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms :
Genetic Predisposition to Disease*/epidemiology
Genetic Predisposition to Disease*/genetics
Heart Disease Risk Factors*
Risk Assessment*/methods
Risk Assessment*/standards
Stroke/*epidemiology
Stroke/*genetics
Adult ; Aged ; Asian Continental Ancestry Group ; Case-Control Studies ; China/epidemiology ; Cohort Studies ; Female ; Genome-Wide Association Study ; Humans ; Incidence ; Male ; Meta-Analysis as Topic ; Middle Aged ; Models, Statistical ; Multifactorial Inheritance ; Reproducibility of Results ; Stroke/blood ; Stroke/prevention & control
Czasopismo naukowe
Tytuł :
Genetic association between bone mineral density and the fracture of distal radius: A case-control study.
Autorzy :
Li H; Department of Orthopedics, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong, China.
Fu M
Gao J
Fu J
Li T
Niu G
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Sep 10; Vol. 100 (36), pp. e27116.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Predisposition to Disease*
Bone Diseases, Metabolic/*complications
Osteoporotic Fractures/*epidemiology
Radius Fractures/*epidemiology
Absorptiometry, Photon ; Asian Continental Ancestry Group ; Case-Control Studies ; China/epidemiology ; Female ; Humans ; Middle Aged ; Osteoporotic Fractures/etiology ; Osteoporotic Fractures/genetics ; Radius Fractures/etiology ; Radius Fractures/genetics ; Retrospective Studies ; Risk Factors
Czasopismo naukowe
Tytuł :
Lack of association of FKBP5 SNPs and haplotypes with susceptibility and treatment response phenotypes in Han Chinese with major depressive disorder: A pilot case-control study (STROBE).
Autorzy :
Yang C; Biological psychiatry Laboratory, Tianjin Mental Health Institute, Tianjin Anding Hospital, Tianjin, China.; University of Groningen, University Medical Centre Groningen, University Centre of Psychiatry, Groningen, the Netherlands.
Li S; Biological psychiatry Laboratory, Tianjin Mental Health Institute, Tianjin Anding Hospital, Tianjin, China.; Department of Psychiatry, College of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Ma Y; Biological psychiatry Laboratory, Tianjin Mental Health Institute, Tianjin Anding Hospital, Tianjin, China.
Chen B; Department of Psychiatry, College of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Li M; Biological psychiatry Laboratory, Tianjin Mental Health Institute, Tianjin Anding Hospital, Tianjin, China.
Bosker FJ; University of Groningen, University Medical Centre Groningen, University Centre of Psychiatry, Groningen, the Netherlands.; University of Groningen, Research School Behavioral and Cognitive Neurosciences (BCN).
Li J; Biological psychiatry Laboratory, Tianjin Mental Health Institute, Tianjin Anding Hospital, Tianjin, China.
Nolte IM; University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Sep 10; Vol. 100 (36), pp. e26983.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Predisposition to Disease*
Depressive Disorder, Major/*drug therapy
Tacrolimus Binding Proteins/*genetics
Adolescent ; Adult ; Aged ; Asian Continental Ancestry Group ; Case-Control Studies ; China ; Depressive Disorder, Major/genetics ; Female ; Haplotypes ; Humans ; Male ; Middle Aged ; Phenotype ; Polymorphism, Single Nucleotide ; Young Adult
Czasopismo naukowe
Tytuł :
Genetic susceptibility of δ-ALAD associated with lead (Pb) intoxication: sources of exposure, preventive measures, and treatment interventions.
Autorzy :
Qader A; Department of Pharmaceutical Chemistry, Government College University, Faisalabad, Pakistan.
Rehman K; Department of Pharmacy, University of Agriculture, Faisalabad, Pakistan.
Akash MSH; Department of Pharmaceutical Chemistry, Government College University, Faisalabad, Pakistan. .
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Źródło :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2021 Sep; Vol. 28 (33), pp. 44818-44832. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genetic Predisposition to Disease*
Lead*
Occupational Exposure*
Porphobilinogen Synthase*/genetics
Lead Poisoning/*genetics
Humans ; Polymorphism, Genetic
Czasopismo naukowe
Tytuł :
Evaluating marginal genetic correlation of associated loci for complex diseases and traits between European and East Asian populations.
Autorzy :
Lu H; Department of Epidemiology and Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Wang T; Department of Epidemiology and Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Zhang J; Department of Epidemiology and Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Zhang S; Department of Epidemiology and Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Huang S; Department of Epidemiology and Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.; Center for Medical Statistics and Data Analysis, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Zeng P; Department of Epidemiology and Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China. .; Center for Medical Statistics and Data Analysis, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China. .
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Źródło :
Human genetics [Hum Genet] 2021 Sep; Vol. 140 (9), pp. 1285-1297. Date of Electronic Publication: 2021 Jun 06.
Typ publikacji :
Evaluation Study; Journal Article
MeSH Terms :
Genetic Predisposition to Disease*
Polymorphism, Single Nucleotide*
Asian Continental Ancestry Group/*genetics
Breast Neoplasms/*genetics
European Continental Ancestry Group/*genetics
Female ; Genome-Wide Association Study ; Humans
Czasopismo naukowe
Tytuł :
A rare variant in EZH2 is associated with prostate cancer risk.
Autorzy :
Raspin K; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
FitzGerald LM; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Marthick JR; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Field MA; Australian Institute of Tropical Health and Medicine and Centre for Tropical Bioinformatics and Molecular Biology, James Cook University, Cairns, Queensland, Australia.; John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.
Malley RC; Hobart Pathology, Hobart, Tasmania, Australia.; Tasmanian School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
Banks A; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Donovan S; Hobart Pathology, Hobart, Tasmania, Australia.
Thomson RJ; Centre for Research in Mathematics and Data Science, Western Sydney University, Sydney, New South Wales, Australia.
Foley GR; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Stanford JL; Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Dickinson JL; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
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Źródło :
International journal of cancer [Int J Cancer] 2021 Sep 01; Vol. 149 (5), pp. 1089-1099. Date of Electronic Publication: 2021 Apr 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Predisposition to Disease*
Polymorphism, Single Nucleotide*
Transcriptome*
Biomarkers, Tumor/*genetics
Enhancer of Zeste Homolog 2 Protein/*genetics
Prostatic Neoplasms/*epidemiology
Aged ; Aged, 80 and over ; Follow-Up Studies ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; Prognosis ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Risk Factors ; Tasmania/epidemiology ; Tumor Cells, Cultured ; United States/epidemiology
Czasopismo naukowe
Tytuł :
Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C).
Autorzy :
Chou J; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass. Electronic address: .
Platt CD; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Habiballah S; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Nguyen AA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Elkins M; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Weeks S; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Peters Z; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Day-Lewis M; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Novak T; Division of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Armant M; The TransLab, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Williams L; The Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Rockowitz S; Computational Health Informatics Program, Boston Children's Hospital, Harvard Medical School, Boston, Mass; The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Sliz P; Computational Health Informatics Program, Boston Children's Hospital, Harvard Medical School, Boston, Mass; The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Williams DA; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Mass; Department of Pediatric Oncology, the Dana-Farber Cancer Institute, Harvard Medical School, Boston, Mass; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Randolph AG; Division of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Geha RS; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
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Corporate Authors :
Taking on COVID-19 Together Study Investigators
Źródło :
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2021 Sep; Vol. 148 (3), pp. 732-738.e1. Date of Electronic Publication: 2021 Jul 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Disease Susceptibility*
Genetic Predisposition to Disease*
COVID-19/*etiology
COVID-19/*metabolism
Systemic Inflammatory Response Syndrome/*etiology
Systemic Inflammatory Response Syndrome/*metabolism
Biomarkers ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/virology ; Child ; Child, Preschool ; Cytokines/metabolism ; Female ; Host-Pathogen Interactions/immunology ; Humans ; Male ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/diagnosis
SCR Disease Name :
pediatric multisystem inflammatory disease, COVID-19 related
Czasopismo naukowe
Tytuł :
Compound heterozygosity for two novel mutations of the SEC23B gene in congenital dyserythropoietic anemia type II.
Autorzy :
Chen S; Department of Hematology, Affiliated Zhongshan Hospital, Sun Yat-Sen University, No. 2 Sun-wen Dong Road, Zhongshan, 528403, China.
Guo Z; Department of Hematology, Affiliated Zhongshan Hospital, Sun Yat-Sen University, No. 2 Sun-wen Dong Road, Zhongshan, 528403, China.
Ye Y; Department of Hematology, Affiliated Zhongshan Hospital, Sun Yat-Sen University, No. 2 Sun-wen Dong Road, Zhongshan, 528403, China.
Yang S; Department of Laboratory Medicine, Affiliated Zhongshan Hospital, Sun Yat-Sen University, Zhongshan, Guangdong, China.
Huang G; Department of Hematology, Affiliated Zhongshan Hospital, Sun Yat-Sen University, No. 2 Sun-wen Dong Road, Zhongshan, 528403, China. .
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Źródło :
International journal of hematology [Int J Hematol] 2021 Sep; Vol. 114 (3), pp. 390-394. Date of Electronic Publication: 2021 Apr 29.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Genetic Association Studies*/methods
Genetic Predisposition to Disease*
Heterozygote*
Mutation*
Anemia, Dyserythropoietic, Congenital/*diagnosis
Anemia, Dyserythropoietic, Congenital/*genetics
Vesicular Transport Proteins/*genetics
Adult ; Alleles ; Biopsy ; Bone Marrow/metabolism ; Humans ; Male ; Pedigree ; Symptom Assessment ; Tomography, X-Ray Computed ; Vesicular Transport Proteins/chemistry ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł :
Whole genome sequencing identifies variants associated with sarcoidosis in a family with a high prevalence of sarcoidosis.
Autorzy :
Fritz D; Department of Neurology, Amsterdam Neuroscience, University of Amsterdam, Amsterdam UMC, P.O. Box 22660, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.
Ferwerda B; Department of Neurology, Amsterdam Neuroscience, University of Amsterdam, Amsterdam UMC, P.O. Box 22660, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.
Brouwer MC; Department of Neurology, Amsterdam Neuroscience, University of Amsterdam, Amsterdam UMC, P.O. Box 22660, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.
van de Beek D; Department of Neurology, Amsterdam Neuroscience, University of Amsterdam, Amsterdam UMC, P.O. Box 22660, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands. .
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Źródło :
Clinical rheumatology [Clin Rheumatol] 2021 Sep; Vol. 40 (9), pp. 3735-3743. Date of Electronic Publication: 2021 Apr 27.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Predisposition to Disease*
Sarcoidosis*/genetics
Basic-Leucine Zipper Transcription Factors/genetics ; Humans ; Janus Kinase 2/genetics ; NADPH Oxidases/genetics ; Prevalence ; Whole Exome Sequencing ; Whole Genome Sequencing
Czasopismo naukowe
Tytuł :
Differential genetic influences over colorectal cancer risk and gene expression in large bowel mucosa.
Autorzy :
Vaughan-Shaw PG; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Timofeeva M; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Department of Public Health, D-IAS, Danish Institute for Advanced Study, University of Southern Denmark, Odense, Denmark.
Ooi LY; Department of Pathology, National University Hospital, Singapore.
Svinti V; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Grimes G; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Smillie C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Blackmur JP; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Donnelly K; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Theodoratou E; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Campbell H; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Zgaga L; Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland.
Din FVN; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Farrington SM; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Dunlop MG; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
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Źródło :
International journal of cancer [Int J Cancer] 2021 Sep 01; Vol. 149 (5), pp. 1100-1108. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Genetic Predisposition to Disease*
Polymorphism, Single Nucleotide*
Quantitative Trait Loci*
Biomarkers, Tumor/*genetics
Colorectal Neoplasms/*genetics
Intestinal Mucosa/*metabolism
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Colorectal Neoplasms/etiology ; Colorectal Neoplasms/pathology ; Female ; Follow-Up Studies ; Genome-Wide Association Study ; Genotype ; Humans ; Intestinal Mucosa/pathology ; Male ; Middle Aged ; Prognosis ; Risk Factors ; Transcriptome ; Young Adult
Czasopismo naukowe
Tytuł :
Association of GSTM1 and GSTT1 gene polymorphisms with COVID-19 susceptibility and its outcome.
Autorzy :
Abbas M; Department of Personalized and Molecular Medicine, Era University, Lucknow, Uttar Pradesh, India.; Department of Microbiology, Era University, Lucknow, Uttar Pradesh, India.
Verma S; Department of Personalized and Molecular Medicine, Era University, Lucknow, Uttar Pradesh, India.
Verma S; Department of Personalized and Molecular Medicine, Era University, Lucknow, Uttar Pradesh, India.
Siddiqui S; Department of Biochemistry, Eras Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh, India.
Khan FH; Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, National University of Ireland Galway, Galway, Ireland.
Raza ST; Department of Biochemistry, Eras Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh, India.
Siddiqi Z; Department of Medicine, Eras Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh, India.
Eba A; Department of Biochemistry, Eras Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh, India.
Mahdi F; Department of Personalized and Molecular Medicine, Era University, Lucknow, Uttar Pradesh, India.
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Źródło :
Journal of medical virology [J Med Virol] 2021 Sep; Vol. 93 (9), pp. 5446-5451. Date of Electronic Publication: 2021 Jun 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Predisposition to Disease*
Polymorphism, Genetic*
COVID-19/*genetics
Glutathione Transferase/*genetics
SARS-CoV-2/*pathogenicity
Adult ; Aged ; Alleles ; COVID-19/mortality ; COVID-19/pathology ; COVID-19/virology ; COVID-19 Nucleic Acid Testing ; Female ; Follow-Up Studies ; Gene Expression ; Gene Frequency ; Glutathione/metabolism ; Humans ; Male ; Middle Aged ; Oxidative Stress ; Proportional Hazards Models ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Prothrombotic state associated with preeclampsia.
Autorzy :
Han C; Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin, China.
Chen YY; Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin, China.
Dong JF; Bloodworks Research Institute.; Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
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Źródło :
Current opinion in hematology [Curr Opin Hematol] 2021 Sep 01; Vol. 28 (5), pp. 323-330.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genetic Predisposition to Disease*
Pre-Eclampsia*/blood
Pre-Eclampsia*/genetics
Thrombosis*/blood
Thrombosis*/genetics
Blood Platelets/metabolism ; Female ; Humans ; Placenta/metabolism ; Platelet Adhesiveness ; Pregnancy ; Pregnancy Proteins/blood ; Pregnancy Proteins/genetics
Czasopismo naukowe
Tytuł :
An overview of germline variations in genes of primary immunodeficiences through integrative analysis of ClinVar, HGMD and dbSNP databases.
Autorzy :
Salnikova LE; The Laboratory of Ecological Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkin Street, Moscow, 117971, Russia. .; The Laboratory of Molecular Immunology, Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia. .; The Laboratory of Clinical Pathophysiology of Critical Conditions, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia. .
Kolobkov DS; The Laboratory of Ecological Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkin Street, Moscow, 117971, Russia.; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Sviridova DA; The Laboratory of Ecological Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkin Street, Moscow, 117971, Russia.
Abilev SK; The Laboratory of Ecological Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkin Street, Moscow, 117971, Russia.
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Źródło :
Human genetics [Hum Genet] 2021 Sep; Vol. 140 (9), pp. 1379-1393. Date of Electronic Publication: 2021 Jul 16.
Typ publikacji :
Journal Article
MeSH Terms :
Databases, Genetic*
Genetic Predisposition to Disease*
Polymorphism, Single Nucleotide*
Primary Immunodeficiency Diseases/*genetics
Female ; Humans ; Male
Czasopismo naukowe
Tytuł :
Germline variants in hereditary breast cancer genes are associated with early age at diagnosis and family history in Guatemalan breast cancer.
Autorzy :
Ren M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD, USA.
Orozco A; Instituto Cancerologia, Guatemala City, Guatemala.
Shao K; BGI-Shenzhen, Beishan Industrial Zone, Shenzhen, 518083, People's Republic of China.
Albanez A; Instituto Cancerologia, Guatemala City, Guatemala.
Ortiz J; Instituto Cancerologia, Guatemala City, Guatemala.
Cao B; BGI-Shenzhen, Beishan Industrial Zone, Shenzhen, 518083, People's Republic of China.
Wang L; City University of Hong Kong Shenzhen Research Institute, Shenzhen, People's Republic of China.; Department of Computer Science, City University of Hong Kong, Kowloon, SAR, Hong Kong, People's Republic of China.
Barreda L; Hospital General San Juan de Dios, Guatemala City, Guatemala.
Alvarez CS; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD, USA.
Garland L; Cancer Genetics Research Laboratory, Division of Cancer Epidemiology and Genetics, Frederick National Laboratory for Cancer Research, Gaithersburg, MD, USA.
Wu D; Cancer Genetics Research Laboratory, Division of Cancer Epidemiology and Genetics, Frederick National Laboratory for Cancer Research, Gaithersburg, MD, USA.
Chung CC; Cancer Genetics Research Laboratory, Division of Cancer Epidemiology and Genetics, Frederick National Laboratory for Cancer Research, Gaithersburg, MD, USA.; Office of Biostatistics and Epidemiology (OBE), Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Silver Spring, MD , 20993-0002, USA.
Wang J; Cancer Genetics Research Laboratory, Division of Cancer Epidemiology and Genetics, Frederick National Laboratory for Cancer Research, Gaithersburg, MD, USA.
Frone M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD, USA.
Ralon S; Hospital General San Juan de Dios, Guatemala City, Guatemala.
Argueta V; Hospital General San Juan de Dios, Guatemala City, Guatemala.
Orozco R; Hospital General San Juan de Dios, Guatemala City, Guatemala. .
Gharzouzi E; Integra Cancer Center, Guatemala City, Guatemala. .
Dean M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD, USA. .
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Źródło :
Breast cancer research and treatment [Breast Cancer Res Treat] 2021 Sep; Vol. 189 (2), pp. 533-539. Date of Electronic Publication: 2021 Jul 01.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms*/diagnosis
Breast Neoplasms*/epidemiology
Breast Neoplasms*/genetics
Genetic Predisposition to Disease*
Germ-Line Mutation*
BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Female ; Genes, BRCA2 ; Germ Cells ; Guatemala ; Humans
Czasopismo naukowe
Tytuł :
The genetic architecture of primary biliary cholangitis.
Autorzy :
Gerussi A; Division of Gastroenterology, Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, Monza, Italy; Ancient DNA Lab, Dan David Center for Human Evolution and Biohistory Research, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: .
Carbone M; Division of Gastroenterology, Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, Monza, Italy.
Corpechot C; Reference Center for Inflammatory Biliary Diseases and Autoimmune Hepatitis (MIVB-H), French Network on Rare Liver Diseases (FILFOIE), Saint-Antoine Hospital, Assistance Publique - Hôpitaux de Paris, Sorbonne University, Paris, France; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Saint- Antoine Hospital, Paris, France.
Schramm C; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany.
Asselta R; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, 20072, Italy; IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy.
Invernizzi P; Division of Gastroenterology, Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, Monza, Italy. Electronic address: .
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Źródło :
European journal of medical genetics [Eur J Med Genet] 2021 Sep; Vol. 64 (9), pp. 104292. Date of Electronic Publication: 2021 Jul 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genetic Predisposition to Disease*
Liver Cirrhosis, Biliary/*genetics
Animals ; Humans ; Liver Cirrhosis, Biliary/pathology ; Multifactorial Inheritance
Czasopismo naukowe
Tytuł :
Update on human genetic susceptibility to COVID-19: susceptibility to virus and response.
Autorzy :
Colona VL; Department of Biomedicine and Prevention, 'Tor Vergata' University of Rome, 00133, Rome, Italy.
Vasiliou V; Department of Environmental Health Sciences, School of Public Health, Yale University, New Haven, USA.
Watt J; College of Public Health, Medical and Veterinary Sciences, James Cook University, Smithfield, QLD, Australia.
Novelli G; Department of Biomedicine and Prevention, 'Tor Vergata' University of Rome, 00133, Rome, Italy.; IRCCS Neuromed, Pozzilli, IS, Italy.; Department of Pharmacology, School of Medicine, University of Nevada, Reno, NV, 89557, USA.
Reichardt JKV; Australian Institute of Tropical Health and Medicine, James Cook University, Smithfield, QLD, 4878, Australia. .
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Źródło :
Human genomics [Hum Genomics] 2021 Aug 25; Vol. 15 (1), pp. 57. Date of Electronic Publication: 2021 Aug 25.
Typ publikacji :
Editorial
MeSH Terms :
Genetic Predisposition to Disease*
COVID-19/*genetics
Angiotensin-Converting Enzyme 2/genetics ; COVID-19/virology ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/genetics ; Genome-Wide Association Study ; Host-Pathogen Interactions/genetics ; Humans ; Immunity, Innate/genetics ; Interferon-alpha/genetics ; Polymorphism, Single Nucleotide ; TYK2 Kinase/genetics
Opinia redakcyjna
Tytuł :
A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.
Autorzy :
Guan Y; Department of Medicine, Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Liang X; Department of Medicine, Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ma Z; Department of Medicine, Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Hu H; Department of Medicine, Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Liu H; Department of Medicine, Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Miao Z; Department of Medicine, Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Graduate group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Linkermann A; Division of Nephrology, Department of Internal Medicine, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.; Biotechnology Center, Technische Universität Dresden, 01307, Dresden, Germany.
Hellwege JN; Division of Genetic Medicine, Department of Medicine, Vanderbilt Genetics Institute, Nashville, TN, 37232, USA.
Voight BF; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Institute of Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Susztak K; Department of Medicine, Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. .; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 23; Vol. 12 (1), pp. 5078. Date of Electronic Publication: 2021 Aug 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Loci*
Genetic Predisposition to Disease*
Dipeptidases/*genetics
Ferroptosis/*genetics
Kidney Diseases/*genetics
Vesicular Transport Proteins/*genetics
Animals ; Blood Urea Nitrogen ; Chromatin/metabolism ; Cisplatin ; DNA Methylation/genetics ; Dipeptidases/deficiency ; Dipeptidases/metabolism ; Folic Acid ; Gene Editing ; Gene Expression Regulation ; Genome-Wide Association Study ; Haploinsufficiency/genetics ; Humans ; Iron/metabolism ; Kidney/pathology ; Kidney Diseases/chemically induced ; Mice ; Necroptosis/genetics ; Organ Specificity ; Physical Chromosome Mapping ; Pyroptosis/genetics ; Quantitative Trait Loci ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Vesicular Transport Proteins/deficiency ; Vesicular Transport Proteins/metabolism
Czasopismo naukowe
Tytuł :
Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases.
Autorzy :
Kapoor M; Departments of Genetics and Genomic Sciences and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .
Chao MJ; Departments of Genetics and Genomic Sciences and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Johnson EC; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Novikova G; Departments of Genetics and Genomic Sciences and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lai D; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Meyers JL; Department of Psychiatry, State University of New York, Downstate Medical Center, Brooklyn, NY, USA.
Schulman J; Departments of Genetics and Genomic Sciences and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nurnberger JI Jr; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Porjesz B; Department of Psychiatry, State University of New York, Downstate Medical Center, Brooklyn, NY, USA.
Liu Y; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Foroud T; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Edenberg HJ; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Marcora E; Departments of Genetics and Genomic Sciences and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Agrawal A; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Goate A; Departments of Genetics and Genomic Sciences and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .
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Corporate Authors :
Collaborative Study on the Genetics of Alcoholism (COGA)
Źródło :
Nature communications [Nat Commun] 2021 Aug 20; Vol. 12 (1), pp. 5071. Date of Electronic Publication: 2021 Aug 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Genetic Predisposition to Disease*
Genome-Wide Association Study*
Genomics*
Alcoholism/*genetics
Neurodegenerative Diseases/*genetics
Brain/metabolism ; Epigenesis, Genetic ; Fetus/metabolism ; Gene Regulatory Networks ; Genetic Loci ; Genetic Markers ; Humans ; Linkage Disequilibrium/genetics ; Mendelian Randomization Analysis ; Physical Chromosome Mapping ; Promoter Regions, Genetic/genetics ; Quantitative Trait Loci/genetics
Czasopismo naukowe
Tytuł :
Pathogenic Mechanisms of Hypertrophic Cardiomyopathy beyond Sarcomere Dysfunction.
Autorzy :
Chou C; Department of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA.
Chin MT; Department of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA.; Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 19; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 19.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genetic Predisposition to Disease*
Phenotype*
Cardiomyopathy, Hypertrophic/*pathology
Sarcomeres/*pathology
Cardiomyopathy, Hypertrophic/etiology ; Humans
Czasopismo naukowe
Tytuł :
Comment on: homozygous variant p. Arg90His in NCF1 is associated with early-onset interferonopathy: a case report.
Autorzy :
Goulielmos GN; Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, University of Crete, Heraklion, Greece. .; Department of Internal Medicine, University Hospital of Heraklion, Heraklion, Greece. .
Zervou MI; Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, University of Crete, Heraklion, Greece.
Eliopoulos E; Laboratory of Genetics, Department of Biotechnology, Agricultural University of Athens, Athens, Greece.
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Źródło :
Pediatric rheumatology online journal [Pediatr Rheumatol Online J] 2021 Aug 16; Vol. 19 (1), pp. 125. Date of Electronic Publication: 2021 Aug 16.
Typ publikacji :
Letter; Comment
MeSH Terms :
Genetic Predisposition to Disease*
Polymorphism, Single Nucleotide*
Homozygote ; Humans
Opinia redakcyjna

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