Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Zmień bibliotekę

Wyszukujesz frazę ""LIBRARIES"" wg kryterium: Temat


Tytuł :
Digital Accommodations for Students Living with Print Disabilities: A Literature Review.
Autorzy :
Lorbeer ER; Department of the Medical Library, Homer Stryker M.D. School of Medicine, Western Michigan University, Kalamazoo, USA.
Pokaż więcej
Źródło :
Medical reference services quarterly [Med Ref Serv Q] 2020 Apr-Jun; Vol. 39 (2), pp. 139-152.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Access to Information*
Disabled Persons*
Libraries, Digital*
Libraries, Medical ; Students, Medical
Czasopismo naukowe
Tytuł :
High-Throughput Affinity Selection Mass Spectrometry Using SAMDI-MS to Identify Small-Molecule Binders of the Human Rhinovirus 3C Protease.
Autorzy :
Scholle MD; SAMDI Tech, Inc., Chicago, IL, USA.
McLaughlin D; MoMa Therapeutics, Boston, MA, USA.
Gurard-Levin ZA; SAMDI Tech, Inc., Chicago, IL, USA.
Pokaż więcej
Źródło :
SLAS discovery : advancing life sciences R & D [SLAS Discov] 2021 Sep; Vol. 26 (8), pp. 974-983. Date of Electronic Publication: 2021 Jun 19.
Typ publikacji :
Journal Article
MeSH Terms :
High-Throughput Screening Assays*
COVID-19/*drug therapy
Rhinovirus/*drug effects
Small Molecule Libraries/*chemistry
3C Viral Proteases/chemistry ; COVID-19/virology ; Drug Discovery ; Humans ; Ligands ; Mass Spectrometry ; SARS-CoV-2/drug effects ; SARS-CoV-2/pathogenicity ; Small Molecule Libraries/isolation & purification ; Small Molecule Libraries/therapeutic use
Czasopismo naukowe
Tytuł :
A Michael Acceptor Analogue, SKSI-0412, Down-Regulates Inflammation and Proliferation Factors through Suppressing Signal Transducer and Activator of Transcription 3 Signaling in IL-17A-Induced Human Keratinocyte.
Autorzy :
Kim AR; Department of Dermatology, School of Medicine, CHA University, 120 Haeryong-ro, Pocheon 11160, Gyeonggi-do, Korea.
Lee S; Department of Pharmacy, College of Pharmacy, CHA University, 120 Haeryong-ro, Pocheon 11160, Gyeonggi-do, Korea.
Shin JU; Department of Dermatology, CHA Bundang Mediacal Center, School of Medicine, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 13496, Gyeonggi-do, Korea.
Seok SH; Department of Dermatology, CHA Bundang Mediacal Center, School of Medicine, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 13496, Gyeonggi-do, Korea.
Suh YG; Department of Pharmacy, College of Pharmacy, CHA University, 120 Haeryong-ro, Pocheon 11160, Gyeonggi-do, Korea.
Kim DH; Department of Dermatology, CHA Bundang Mediacal Center, School of Medicine, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 13496, Gyeonggi-do, Korea.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 16; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 16.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Interleukin-17/*adverse effects
Keratinocytes/*cytology
STAT3 Transcription Factor/*metabolism
Small Molecule Libraries/*pharmacology
Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/chemistry ; Cell Proliferation/drug effects ; Cells, Cultured ; Down-Regulation ; Humans ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Phosphorylation/drug effects ; Primary Cell Culture ; STAT3 Transcription Factor/chemistry ; Signal Transduction/drug effects ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/chemistry
Czasopismo naukowe
Tytuł :
Understanding the brain uptake and permeability of small molecules through the BBB: A technical overview.
Autorzy :
Chowdhury EA; Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, Amarillo, USA.
Noorani B; Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, Amarillo, USA.
Alqahtani F; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Bhalerao A; Department of Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, USA.
Raut S; Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, Amarillo, USA.
Sivandzade F; Department of Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, USA.
Cucullo L; Department of Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, USA.
Pokaż więcej
Źródło :
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2021 Aug; Vol. 41 (8), pp. 1797-1820. Date of Electronic Publication: 2021 Jan 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Blood-Brain Barrier/*metabolism
Brain/*metabolism
Permeability/*drug effects
Small Molecule Libraries/*pharmacology
Animals ; Blood-Brain Barrier/drug effects ; Humans ; Kinetics ; Nervous System Diseases/metabolism ; Nervous System Diseases/pathology ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/metabolism ; Sucrose/chemistry ; Sucrose/metabolism
Czasopismo naukowe
Tytuł :
Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation.
Autorzy :
Dong J; Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang 310022, China.; Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310018, China.
Cheng XD; Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang 310022, China.; Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310018, China.
Zhang WD; School of Pharmacy, Naval Medical University, Shanghai 200433, China.
Qin JJ; Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang 310022, China.; Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310018, China.
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Jul 08; Vol. 64 (13), pp. 8884-8915. Date of Electronic Publication: 2021 Jun 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Development*
Antineoplastic Agents/*pharmacology
Neoplasms/*drug therapy
STAT3 Transcription Factor/*antagonists & inhibitors
Small Molecule Libraries/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Humans ; Molecular Structure ; Neoplasms/metabolism ; Phosphorylation/drug effects ; STAT3 Transcription Factor/metabolism ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/chemistry
Czasopismo naukowe
Tytuł :
Inhibiting Eukaryotic Elongation Factor 2 Kinase: An Update on Pharmacological Small-Molecule Compounds in Cancer.
Autorzy :
Zhu S; State Key Laboratory of Biotherapy and Cancer Center and Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Liao M; State Key Laboratory of Biotherapy and Cancer Center and Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Tan H; State Key Laboratory of Biotherapy and Cancer Center and Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhu L; State Key Laboratory of Biotherapy and Cancer Center and Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Chen Y; State Key Laboratory of Biotherapy and Cancer Center and Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
He G; State Key Laboratory of Biotherapy and Cancer Center and Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Liu B; State Key Laboratory of Biotherapy and Cancer Center and Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Jul 08; Vol. 64 (13), pp. 8870-8883. Date of Electronic Publication: 2021 Jun 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Antineoplastic Agents/*pharmacology
Elongation Factor 2 Kinase/*antagonists & inhibitors
Neoplasms/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Small Molecule Libraries/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Elongation Factor 2 Kinase/metabolism ; Humans ; Models, Molecular ; Molecular Structure ; Neoplasms/metabolism ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/chemistry
Czasopismo naukowe
Tytuł :
Available drugs and supplements for rapid deployment for treatment of COVID-19.
Autorzy :
Cicka D; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.
Sukhatme VP; Department of Medicine, Department of Hematology and Medical Oncology, Morningside Center for Innovative and Affordable Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Pokaż więcej
Źródło :
Journal of molecular cell biology [J Mol Cell Biol] 2021 Jul 06; Vol. 13 (3), pp. 232-236.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
COVID-19/*drug therapy
Drug Repositioning/*trends
SARS-CoV-2/*drug effects
Small Molecule Libraries/*therapeutic use
Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/chemistry ; Adenosine Monophosphate/pharmacokinetics ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/chemistry ; Alanine/pharmacokinetics ; Alanine/therapeutic use ; Animals ; COVID-19/blood ; COVID-19/virology ; Disease Models, Animal ; Flavonoids/chemistry ; Flavonoids/pharmacokinetics ; Flavonoids/therapeutic use ; Humans ; Mice ; Nitro Compounds/chemistry ; Nitro Compounds/pharmacokinetics ; Nitro Compounds/therapeutic use ; Pharmaceutical Preparations ; SARS-CoV-2/pathogenicity ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacokinetics ; Teicoplanin/analogs & derivatives ; Teicoplanin/chemistry ; Teicoplanin/pharmacokinetics ; Teicoplanin/therapeutic use ; Thiazoles/chemistry ; Thiazoles/pharmacokinetics ; Thiazoles/therapeutic use
Czasopismo naukowe
Tytuł :
AAA ATPases as therapeutic targets: Structure, functions, and small-molecule inhibitors.
Autorzy :
Zhang G; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, United States. Electronic address: .
Li S; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, United States.
Cheng KW; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, United States.
Chou TF; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, United States. Electronic address: .
Pokaż więcej
Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Jul 05; Vol. 219, pp. 113446. Date of Electronic Publication: 2021 Apr 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
ATPases Associated with Diverse Cellular Activities/*metabolism
Small Molecule Libraries/*chemistry
ATPases Associated with Diverse Cellular Activities/antagonists & inhibitors ; Binding Sites ; Carbazoles/chemistry ; Carbazoles/metabolism ; Humans ; Molecular Dynamics Simulation ; Neoplasms/drug therapy ; Neoplasms/pathology ; Pyrazoles/chemistry ; Pyrazoles/metabolism ; Pyrimidines/chemistry ; Pyrimidines/metabolism ; Quinazolines/chemistry ; Quinazolines/metabolism ; Small Molecule Libraries/metabolism ; Small Molecule Libraries/therapeutic use ; Zearalenone/analogs & derivatives ; Zearalenone/chemistry ; Zearalenone/metabolism
Czasopismo naukowe
Tytuł :
Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.
Autorzy :
Shukla S; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Ying W; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Gray F; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Yao Y; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Simes ML; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Zhao Q; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Miao H; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Cho HJ; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
González-Alonso P; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Winkler A; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Lund G; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Purohit T; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Kim E; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Zhang X; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Ray JM; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
He S; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Nikolaidis C; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Ndoj J; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Wang J; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; MedImmune, LLC, Gaithersburg, MD, USA.
Jaremko Ł; Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Jaremko M; Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Ryan RJH; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Guzman ML; Division of Hematology and Medical Oncology, Leukemia Program, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, NY, USA.
Grembecka J; Department of Pathology, University of Michigan, Ann Arbor, MI, USA. .
Cierpicki T; Department of Pathology, University of Michigan, Ann Arbor, MI, USA. .
Pokaż więcej
Źródło :
Nature chemical biology [Nat Chem Biol] 2021 Jul; Vol. 17 (7), pp. 784-793. Date of Electronic Publication: 2021 Jun 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Polycomb Repressive Complex 1/*antagonists & inhibitors
Small Molecule Libraries/*pharmacology
Cell Differentiation/drug effects ; Dose-Response Relationship, Drug ; Humans ; K562 Cells ; Models, Molecular ; Molecular Structure ; Polycomb Repressive Complex 1/genetics ; Polycomb Repressive Complex 1/metabolism ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/chemistry ; Ubiquitination/drug effects
Czasopismo naukowe
Tytuł :
Bifunctional small molecules that mediate the degradation of extracellular proteins.
Autorzy :
Caianiello DF; Department of Chemistry, Yale University, New Haven, CT, USA.
Zhang M; Department of Chemistry, Yale University, New Haven, CT, USA.; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
Ray JD; Department of Chemistry, Yale University, New Haven, CT, USA.
Howell RA; Department of Chemistry, Yale University, New Haven, CT, USA.
Swartzel JC; Department of Chemistry, Yale University, New Haven, CT, USA.; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA.
Branham EMJ; Department of Chemistry, Yale University, New Haven, CT, USA.
Chirkin E; Department of Chemistry, Yale University, New Haven, CT, USA.
Sabbasani VR; Department of Chemistry, Yale University, New Haven, CT, USA.
Gong AZ; Department of Chemistry, Yale University, New Haven, CT, USA.
McDonald DM; Department of Chemistry, Yale University, New Haven, CT, USA.
Muthusamy V; Yale Center for Precision Cancer Modeling, Yale University School of Medicine, New Haven, CT, USA.
Spiegel DA; Department of Chemistry, Yale University, New Haven, CT, USA. .
Pokaż więcej
Źródło :
Nature chemical biology [Nat Chem Biol] 2021 Sep; Vol. 17 (9), pp. 947-953. Date of Electronic Publication: 2021 Aug 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Asialoglycoprotein Receptor/*metabolism
Small Molecule Libraries/*pharmacology
Animals ; Dinitrophenols/chemistry ; Dinitrophenols/metabolism ; Hep G2 Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Structure ; Small Molecule Libraries/chemistry
Czasopismo naukowe
Tytuł :
Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS-CoV-2 Genome.
Autorzy :
Sreeramulu S; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Richter C; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Berg H; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Wirtz Martin MA; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Ceylan B; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Matzel T; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Adam J; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Altincekic N; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Azzaoui K; Saverna Therapeutics, Pumpmattenweg 3, 4105, Biel-Benken, Switzerland.
Bains JK; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Blommers MJJ; Saverna Therapeutics, Pumpmattenweg 3, 4105, Biel-Benken, Switzerland.
Ferner J; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Fürtig B; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Göbel M; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Grün JT; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Hengesbach M; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Hohmann KF; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Hymon D; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Knezic B; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Martins JN; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Mertinkus KR; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Niesteruk A; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Peter SA; Department of Biology, Technical University of Darmstadt, Schnittspahnstr. 10, 64287, Darmstadt, Germany.
Pyper DJ; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Qureshi NS; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.; Present address: EMBL Heidelberg, Meyerhofstr. 1, 69117, Heidelberg, Germany.
Scheffer U; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Schlundt A; Institute for Molecular Biosciences, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Schnieders R; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Stirnal E; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Sudakov A; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Tröster A; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Vögele J; Institute for Molecular Biosciences, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Wacker A; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Weigand JE; Department of Biology, Technical University of Darmstadt, Schnittspahnstr. 10, 64287, Darmstadt, Germany.
Wirmer-Bartoschek J; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Wöhnert J; Institute for Molecular Biosciences, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Schwalbe H; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany.
Pokaż więcej
Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Aug 23; Vol. 60 (35), pp. 19191-19200. Date of Electronic Publication: 2021 Aug 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome*
RNA, Viral/*metabolism
SARS-CoV-2/*genetics
Small Molecule Libraries/*metabolism
Drug Evaluation, Preclinical ; Ligands ; Molecular Structure ; Nucleic Acid Conformation ; Proton Magnetic Resonance Spectroscopy ; RNA, Viral/chemistry ; Small Molecule Libraries/chemistry
Czasopismo naukowe
Tytuł :
Bioactive recombinant human oncostatin M for NMR-based screening in drug discovery.
Autorzy :
Mass OA; Biomoleculer Research Center, Boise State University, Boise, ID, 83725, USA.
Tuccinardi J; Department of Chemistry and Biochemistry, Boise State University, 1910 University Dr., Boise, ID, 83725, USA.
Woodbury L; Biomoleculer Research Center, Boise State University, Boise, ID, 83725, USA.
Wolf CL; Biomolecular Sciences Graduate Program, Boise State University, Boise, ID, 83725, USA.; Department of Biological Sciences, Boise State University, Boise, ID, 83725, USA.
Grantham B; Biomoleculer Research Center, Boise State University, Boise, ID, 83725, USA.
Holdaway K; Department of Chemistry and Biochemistry, Boise State University, 1910 University Dr., Boise, ID, 83725, USA.
Pu X; Biomoleculer Research Center, Boise State University, Boise, ID, 83725, USA.; Biomolecular Sciences Graduate Program, Boise State University, Boise, ID, 83725, USA.
King MD; Department of Chemistry and Biochemistry, Boise State University, 1910 University Dr., Boise, ID, 83725, USA.; Biomolecular Sciences Graduate Program, Boise State University, Boise, ID, 83725, USA.
Warner DL; Department of Chemistry and Biochemistry, Boise State University, 1910 University Dr., Boise, ID, 83725, USA.; Biomolecular Sciences Graduate Program, Boise State University, Boise, ID, 83725, USA.
Jorcyk CL; Biomolecular Sciences Graduate Program, Boise State University, Boise, ID, 83725, USA.; Department of Biological Sciences, Boise State University, Boise, ID, 83725, USA.
Warner LR; Biomoleculer Research Center, Boise State University, Boise, ID, 83725, USA. .; Department of Chemistry and Biochemistry, Boise State University, 1910 University Dr., Boise, ID, 83725, USA. .; Biomolecular Sciences Graduate Program, Boise State University, Boise, ID, 83725, USA. .
Pokaż więcej
Źródło :
Scientific reports [Sci Rep] 2021 Aug 10; Vol. 11 (1), pp. 16174. Date of Electronic Publication: 2021 Aug 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Drug Discovery/*methods
Oncostatin M/*antagonists & inhibitors
Small Molecule Libraries/*pharmacology
Binding Sites ; Cell Line, Tumor ; Humans ; Magnetic Resonance Spectroscopy/methods ; Molecular Docking Simulation ; Oncostatin M/chemistry ; Oncostatin M/metabolism ; Phosphorylation ; Protein Binding ; STAT3 Transcription Factor/metabolism ; Small Molecule Libraries/chemistry
Czasopismo naukowe
Tytuł :
Combining High-Throughput Synthesis and High-Throughput Protein Crystallography for Accelerated Hit Identification.
Autorzy :
Sutanto F; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands.
Shaabani S; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands.
Oerlemans R; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands.
Eris D; Photon Science Division, Paul Scherrer Institute, Switzerland.
Patil P; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands.
Hadian M; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands.
Wang M; Photon Science Division, Paul Scherrer Institute, Switzerland.
Sharpe ME; Photon Science Division, Paul Scherrer Institute, Switzerland.
Groves MR; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands.
Dömling A; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands.
Pokaż więcej
Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Aug 09; Vol. 60 (33), pp. 18231-18239. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Coronavirus 3C Proteases/*metabolism
Cysteine Proteinase Inhibitors/*metabolism
Small Molecule Libraries/*metabolism
Acrylamides/chemical synthesis ; Acrylamides/metabolism ; Acrylates/chemical synthesis ; Acrylates/metabolism ; Catalytic Domain ; Coronavirus 3C Proteases/antagonists & inhibitors ; Coronavirus 3C Proteases/chemistry ; Crystallography, X-Ray ; Cysteine Proteinase Inhibitors/chemical synthesis ; Drug Discovery ; High-Throughput Screening Assays ; Protein Binding ; SARS-CoV-2/chemistry ; Small Molecule Libraries/chemical synthesis
Czasopismo naukowe
Tytuł :
Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors.
Autorzy :
Brosey CA; Department of Molecular and Cellular Oncology, M. D. Anderson Cancer Center, Houston, TX, 77030, USA. Electronic address: .
Houl JH; Department of Molecular and Cellular Oncology, M. D. Anderson Cancer Center, Houston, TX, 77030, USA.
Katsonis P; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Balapiti-Modarage LPF; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Bommagani S; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Arvai A; Integrative Structural & Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Moiani D; Department of Molecular and Cellular Oncology, M. D. Anderson Cancer Center, Houston, TX, 77030, USA.
Bacolla A; Department of Molecular and Cellular Oncology, M. D. Anderson Cancer Center, Houston, TX, 77030, USA.
Link T; Department of Molecular and Cellular Oncology, M. D. Anderson Cancer Center, Houston, TX, 77030, USA.
Warden LS; Department of Molecular and Cellular Oncology, M. D. Anderson Cancer Center, Houston, TX, 77030, USA.
Lichtarge O; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Jones DE; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Ahmed Z; Department of Molecular and Cellular Oncology, M. D. Anderson Cancer Center, Houston, TX, 77030, USA. Electronic address: .
Tainer JA; Department of Molecular and Cellular Oncology, M. D. Anderson Cancer Center, Houston, TX, 77030, USA; Department of Cancer Biology, M.D. Anderson Cancer Center, Houston, TX, 77030, USA; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA. Electronic address: .
Pokaż więcej
Źródło :
Progress in biophysics and molecular biology [Prog Biophys Mol Biol] 2021 Aug; Vol. 163, pp. 171-186. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antiviral Agents/*chemistry
Coronavirus Papain-Like Proteases/*metabolism
Enzyme Inhibitors/*chemistry
Glycoside Hydrolases/*antagonists & inhibitors
Small Molecule Libraries/*chemistry
Xanthines/*chemistry
Amino Acid Sequence ; Antiviral Agents/pharmacology ; COVID-19/drug therapy ; Catalytic Domain ; Crystallography, X-Ray ; Drug Discovery ; Enzyme Inhibitors/pharmacology ; Humans ; Models, Molecular ; Protein Domains ; SARS-CoV-2/drug effects ; SARS-CoV-2/metabolism ; Small Molecule Libraries/pharmacology ; Structure-Activity Relationship ; Xanthines/pharmacology
Czasopismo naukowe
Tytuł :
HOPS: high-performance library for (non-)uniform sampling of convex-constrained models.
Autorzy :
Jadebeck JF; Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.; Computational Systems Biotechnology (AVT.CSB), RWTH Aachen University, 52062 Aachen, Germany.
Theorell A; Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.
Leweke S; Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.
Nöh K; Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.
Pokaż więcej
Źródło :
Bioinformatics (Oxford, England) [Bioinformatics] 2021 Jul 19; Vol. 37 (12), pp. 1776-1777.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Libraries*
Software*
Algorithms ; Bayes Theorem ; Gene Library
Czasopismo naukowe
Tytuł :
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase.
Autorzy :
Basu S; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Mak T; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Ulferts R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Wu M; High Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Deegan T; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Fujisawa R; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Tan KW; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Lim CT; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Basier C; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Canal B; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Curran JF; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Drury LS; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
McClure AW; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Roberts EL; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Weissmann F; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Zeisner TU; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Beale R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Cowling VH; Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Howell M; High Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Labib K; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Diffley JFX; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Pokaż więcej
Źródło :
The Biochemical journal [Biochem J] 2021 Jul 16; Vol. 478 (13), pp. 2481-2497.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Evaluation, Preclinical*
Antiviral Agents/*pharmacology
Exoribonucleases/*antagonists & inhibitors
Methyltransferases/*antagonists & inhibitors
RNA Caps/*metabolism
SARS-CoV-2/*enzymology
Small Molecule Libraries/*pharmacology
Viral Nonstructural Proteins/*antagonists & inhibitors
Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/pharmacology ; Alanine/analogs & derivatives ; Alanine/pharmacology ; Animals ; Antiviral Agents/chemistry ; Chlorobenzenes/pharmacology ; Chlorocebus aethiops ; Enzyme Assays ; Exoribonucleases/genetics ; Exoribonucleases/isolation & purification ; Exoribonucleases/metabolism ; Fluorescence Resonance Energy Transfer ; High-Throughput Screening Assays ; Indazoles/pharmacology ; Indenes/pharmacology ; Indoles/pharmacology ; Methyltransferases/genetics ; Methyltransferases/isolation & purification ; Methyltransferases/metabolism ; Nitriles/pharmacology ; Phenothiazines/pharmacology ; Purines/pharmacology ; Reproducibility of Results ; SARS-CoV-2/drug effects ; Small Molecule Libraries/chemistry ; Substrate Specificity ; Trifluperidol/pharmacology ; Vero Cells ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/isolation & purification ; Viral Nonstructural Proteins/metabolism ; Viral Regulatory and Accessory Proteins/genetics ; Viral Regulatory and Accessory Proteins/isolation & purification ; Viral Regulatory and Accessory Proteins/metabolism
Czasopismo naukowe
Tytuł :
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase.
Autorzy :
Bertolin AP; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Weissmann F; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Zeng J; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Posse V; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Milligan JC; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Canal B; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Ulferts R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Wu M; High Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Drury LS; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Howell M; High Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Beale R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Diffley JFX; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Pokaż więcej
Źródło :
The Biochemical journal [Biochem J] 2021 Jul 16; Vol. 478 (13), pp. 2425-2443.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Evaluation, Preclinical*
Antiviral Agents/*chemistry
Antiviral Agents/*pharmacology
Coronavirus RNA-Dependent RNA Polymerase/*antagonists & inhibitors
SARS-CoV-2/*enzymology
Small Molecule Libraries/*pharmacology
Animals ; Benzoates/pharmacology ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Chlorocebus aethiops ; Coronavirus RNA-Dependent RNA Polymerase/metabolism ; Enzyme Assays ; Fluorescence Resonance Energy Transfer ; High-Throughput Screening Assays ; Holoenzymes/metabolism ; Reproducibility of Results ; SARS-CoV-2/drug effects ; Small Molecule Libraries/chemistry ; Suramin/pharmacology ; Vero Cells ; Viral Nonstructural Proteins/antagonists & inhibitors ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies