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Wyszukujesz frazę ""Liver Neoplasms"" wg kryterium: Temat


Tytuł :
Discovery of an Orally Efficacious MYC Inhibitor for Liver Cancer Using a GNMT-Based High-Throughput Screening System and Structure-Activity Relationship Analysis.
Autorzy :
Kant R; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Yang MH; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan.
Tseng CH; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Yen CH; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Research Center for Natural Products and Drug Development, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Li WY; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Tyan YC; Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Chen M; Department of Urology, Mackay Memorial Hospital, Taipei 10449, Taiwan.
Tzeng CC; Department of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Chen WC; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
You K; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Wang WC; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan.
Chen YL; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Chen YA; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Jul 08; Vol. 64 (13), pp. 8992-9009. Date of Electronic Publication: 2021 Jun 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Discovery*
High-Throughput Screening Assays*
Antineoplastic Agents/*pharmacology
Glycine N-Methyltransferase/*genetics
Liver Neoplasms/*drug therapy
Proto-Oncogene Proteins c-myc/*antagonists & inhibitors
Administration, Oral ; Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Female ; Glycine N-Methyltransferase/metabolism ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Liver Neoplasms, Experimental/drug therapy ; Liver Neoplasms, Experimental/metabolism ; Liver Neoplasms, Experimental/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Structure ; Promoter Regions, Genetic/drug effects ; Promoter Regions, Genetic/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Preferential Expression of Programmed Death Ligand 1 Protein in Tumor-Associated Macrophages and Its Potential Role in Immunotherapy for Hepatocellular Carcinoma.
Autorzy :
Park DJ; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Sung PS; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
Lee GW; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Cho S; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Kim SM; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Kang BY; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Hur W; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Yang H; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Internal Medicine, College of Medicine, Eunpyeong St. Mary's Hospital, The Catholic University of Korea, Seoul 03383, Korea.
Lee SK; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
Lee SH; Department of Clinical Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Jung ES; Department of Hospital Pathology, College of Medicine, Eunpyeong St. Mary's Hospital, The Catholic University of Korea, Seoul 03383, Korea.
Seo CH; Department of Surgery, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
Ahn J; Department of Surgery, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
Choi HJ; Department of Surgery, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
You YK; Department of Surgery, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
Jang JW; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
Bae SH; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Internal Medicine, College of Medicine, Eunpyeong St. Mary's Hospital, The Catholic University of Korea, Seoul 03383, Korea.
Choi JY; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
Yoon SK; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 29; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 29.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Immunological/*pharmacology
B7-H1 Antigen/*biosynthesis
Carcinoma, Hepatocellular/*immunology
Immune Checkpoint Inhibitors/*pharmacology
Immunotherapy/*methods
Liver Neoplasms/*immunology
Molecular Targeted Therapy/*methods
Neoplasm Proteins/*biosynthesis
Nivolumab/*pharmacology
Tumor Microenvironment/*immunology
Tumor-Associated Macrophages/*metabolism
Animals ; Antineoplastic Agents, Immunological/therapeutic use ; B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/genetics ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/therapy ; Coculture Techniques ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Ki-67 Antigen/biosynthesis ; Ki-67 Antigen/genetics ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Liver Neoplasms, Experimental/immunology ; Lymphocytes, Tumor-Infiltrating/immunology ; Mice ; Mice, Inbred C57BL ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/genetics ; Nivolumab/therapeutic use ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Tumor Cells, Cultured ; Tumor-Associated Macrophages/drug effects
Czasopismo naukowe
Tytuł :
Saxagliptin defers thioacetamide-induced hepatocarcinogenesis in rats: A novel suppressive impact on Wnt/Hedgehog/Notch1 signaling.
Autorzy :
Abd Elhameed AG; Dep. of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt; Dep. of Pharmacology, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt.
Helal MG; Dep. of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Said E; Dep. of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt. Electronic address: .
Salem HA; Dep. of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
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Źródło :
Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2021 Aug; Vol. 86, pp. 103668. Date of Electronic Publication: 2021 May 01.
Typ publikacji :
Journal Article
MeSH Terms :
Adamantane/*analogs & derivatives
Carcinoma, Hepatocellular/*drug therapy
Dipeptides/*therapeutic use
Dipeptidyl-Peptidase IV Inhibitors/*therapeutic use
Liver Neoplasms/*drug therapy
Liver Neoplasms, Experimental/*drug therapy
Adamantane/pharmacology ; Adamantane/therapeutic use ; Animals ; Apoptosis/drug effects ; Carcinoma, Hepatocellular/chemically induced ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation/drug effects ; Dipeptides/pharmacology ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Hedgehog Proteins/metabolism ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Liver Neoplasms, Experimental/metabolism ; Liver Neoplasms, Experimental/pathology ; Male ; Rats, Sprague-Dawley ; Receptor, Notch1/metabolism ; Thioacetamide ; Wnt Signaling Pathway/drug effects
Czasopismo naukowe
Tytuł :
An aptamer-based drug delivery agent (CD133-apt-Dox) selectively and effectively kills liver cancer stem-like cells.
Autorzy :
Zhou G; Storr Liver Centre, Westmead Institute for Medical Research, University of Sydney and Westmead Hospital, Westmead, NSW, 2145, Australia.
Da Won Bae S; Storr Liver Centre, Westmead Institute for Medical Research, University of Sydney and Westmead Hospital, Westmead, NSW, 2145, Australia.
Nguyen R; Storr Liver Centre, Westmead Institute for Medical Research, University of Sydney and Westmead Hospital, Westmead, NSW, 2145, Australia.
Huo X; Storr Liver Centre, Westmead Institute for Medical Research, University of Sydney and Westmead Hospital, Westmead, NSW, 2145, Australia.
Han S; Storr Liver Centre, Westmead Institute for Medical Research, University of Sydney and Westmead Hospital, Westmead, NSW, 2145, Australia.
Zhang Z; Renal Inflammation and Immunology Group, Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, 2145, Australia; Department of Urology, The Second Affiliated Hospital of Anhui Medical University, 230601, Anhui, China.
Hebbard L; Discipline of Molecular and Cell Biology, Australian Institute for Tropical Health and Medicine, Centre for Molecular Therapeutics, James Cook University, Townsville, 4811, Australia.
Duan W; School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria, 3217, Australia.
Eslam M; Storr Liver Centre, Westmead Institute for Medical Research, University of Sydney and Westmead Hospital, Westmead, NSW, 2145, Australia.
Liddle C; Storr Liver Centre, Westmead Institute for Medical Research, University of Sydney and Westmead Hospital, Westmead, NSW, 2145, Australia.
Yuen L; Department of Surgery, Westmead Hospital, Westmead, NSW, 2145, Australia.
Lam V; Department of Surgery, Westmead Hospital, Westmead, NSW, 2145, Australia.
Qiao L; Storr Liver Centre, Westmead Institute for Medical Research, University of Sydney and Westmead Hospital, Westmead, NSW, 2145, Australia. Electronic address: .
George J; Storr Liver Centre, Westmead Institute for Medical Research, University of Sydney and Westmead Hospital, Westmead, NSW, 2145, Australia. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2021 Mar 31; Vol. 501, pp. 124-132. Date of Electronic Publication: 2020 Dec 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
AC133 Antigen/*genetics
Aptamers, Nucleotide/*administration & dosage
Carcinoma, Hepatocellular/*drug therapy
Doxorubicin/*administration & dosage
Liver Neoplasms/*drug therapy
Neoplastic Stem Cells/*drug effects
Animals ; Antibiotics, Antineoplastic/administration & dosage ; Antibiotics, Antineoplastic/pharmacokinetics ; Aptamers, Nucleotide/genetics ; Aptamers, Nucleotide/pharmacokinetics ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Doxorubicin/pharmacokinetics ; Drug Carriers/administration & dosage ; Drug Carriers/pharmacokinetics ; Drug Delivery Systems/methods ; HEK293 Cells ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Liver Neoplasms, Experimental/drug therapy ; Liver Neoplasms, Experimental/metabolism ; Liver Neoplasms, Experimental/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology
Czasopismo naukowe
Tytuł :
Ultra-small gold nanoparticles self-assembled by gadolinium ions for enhanced photothermal/photodynamic liver cancer therapy.
Autorzy :
Li B; Department of Biliary Surgery, West China Hospital of Sichuan University, No. 37 Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan, China. .
Sun L
Li T
Zhang Y
Niu X
Xie M
You Z
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Źródło :
Journal of materials chemistry. B [J Mater Chem B] 2021 Jan 28; Vol. 9 (4), pp. 1138-1150. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Photochemotherapy*
Antineoplastic Agents/*pharmacology
Gadolinium/*pharmacology
Gold/*pharmacology
Liver Neoplasms/*drug therapy
Metal Nanoparticles/*chemistry
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Female ; Gadolinium/chemistry ; Gold/chemistry ; Humans ; Ions/chemistry ; Ions/pharmacology ; Liver Neoplasms/pathology ; Liver Neoplasms, Experimental/drug therapy ; Liver Neoplasms, Experimental/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Particle Size ; Surface Properties ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Intratumoral STING Agonist Injection Combined with Irreversible Electroporation Delays Tumor Growth in a Model of Hepatocarcinoma.
Autorzy :
Lasarte-Cia A; Immunology and Immunotherapy Program, Center for Applied Medical Research (CIMA), University of Navarra, 31008 IDISNA, Pamplona, Spain.
Lozano T; Immunology and Immunotherapy Program, Center for Applied Medical Research (CIMA), University of Navarra, 31008 IDISNA, Pamplona, Spain.
Cano D; Department of Radiology, Clínica Universidad de Navarra, Pamplona, Spain.
Martín-Otal C; Immunology and Immunotherapy Program, Center for Applied Medical Research (CIMA), University of Navarra, 31008 IDISNA, Pamplona, Spain.
Navarro F; Immunology and Immunotherapy Program, Center for Applied Medical Research (CIMA), University of Navarra, 31008 IDISNA, Pamplona, Spain.
Gorraiz M; Immunology and Immunotherapy Program, Center for Applied Medical Research (CIMA), University of Navarra, 31008 IDISNA, Pamplona, Spain.
Casares N; Immunology and Immunotherapy Program, Center for Applied Medical Research (CIMA), University of Navarra, 31008 IDISNA, Pamplona, Spain.
Vivas I; Department of Radiology, Clínica Universidad de Navarra, Pamplona, Spain.
Lasarte JJ; Immunology and Immunotherapy Program, Center for Applied Medical Research (CIMA), University of Navarra, 31008 IDISNA, Pamplona, Spain.
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Źródło :
BioMed research international [Biomed Res Int] 2021 Jan 27; Vol. 2021, pp. 8852233. Date of Electronic Publication: 2021 Jan 27 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Ablation Techniques/*methods
Carcinoma, Hepatocellular/*therapy
Cyclic GMP/*analogs & derivatives
Electroporation/*methods
Liver Neoplasms/*therapy
Membrane Proteins/*agonists
Animals ; Cell Line ; Combined Modality Therapy/methods ; Cyclic GMP/administration & dosage ; Female ; Liver Neoplasms, Experimental/therapy ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł :
A Simple Aggregation-Induced Emission Nanoprobe with Deep Tumor Penetration for Hypoxia Detection and Imaging-Guided Surgery in Vivo .
Autorzy :
Zhang Z; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China.
Wang R; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China.
Huang X; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China.
Zhu W; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 211198, China.
He Y; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China.
Liu W; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 211198, China.; Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 211198, China.
Liu F; The Joint Laboratory of China Pharmaceutical University and Taian City Central Hospital, Taian City Central Hospital, Taian 271000, China.; Pharmaceutical Department, Taian City Central Hospital, Taian 271000, China.
Feng F; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China.; Jiangsu Food and Pharmaceutical Science College, Huaian 223003, China.
Qu W; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China.; Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing 211198, China.
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Źródło :
Analytical chemistry [Anal Chem] 2021 Jan 26; Vol. 93 (3), pp. 1627-1635. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Hypoxia*
Optical Imaging*
Carcinoma, Hepatocellular/*diagnostic imaging
Fluorescent Dyes/*chemistry
Liver Neoplasms/*diagnostic imaging
Animals ; Cell Line, Tumor ; Cytochrome P-450 Enzyme System/analysis ; Cytochrome P-450 Enzyme System/metabolism ; Fluorescent Dyes/chemical synthesis ; Humans ; Liver Neoplasms, Experimental/diagnostic imaging ; Male ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł :
Tumor Vascular Microenvironment of Colorectal Hepatic Metastasis and Chemotherapy Response.
Autorzy :
Okamoto H; Department of Surgery, Tsuru Municipal Hospital, Yamanashi, Japan; .; Department of Gastrointestinal & Breast, Endocrine Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Shiba S; Department of Surgery, Tsuru Municipal Hospital, Yamanashi, Japan.; Department of Gastrointestinal & Breast, Endocrine Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Iino H; Department of Gastrointestinal & Breast, Endocrine Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.; Department of Surgery, Kofu Municipal Hospital, Yamanashi, Japan.
Sudoh M; Department of Gastrointestinal & Breast, Endocrine Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Ichikawa D; Department of Gastrointestinal & Breast, Endocrine Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Sep; Vol. 41 (9), pp. 4505-4513.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Colorectal Neoplasms/*drug therapy
Liver Neoplasms/*drug therapy
Liver Neoplasms/*secondary
Adult ; Aged ; Aged, 80 and over ; Antigens, CD34/metabolism ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Camptothecin/analogs & derivatives ; Camptothecin/pharmacology ; Camptothecin/therapeutic use ; Colorectal Neoplasms/diagnostic imaging ; Colorectal Neoplasms/metabolism ; Computed Tomography Angiography ; Female ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use ; Humans ; Leucovorin/pharmacology ; Leucovorin/therapeutic use ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/metabolism ; Male ; Middle Aged ; Organoplatinum Compounds/pharmacology ; Organoplatinum Compounds/therapeutic use ; Retrospective Studies ; Survival Analysis ; Treatment Outcome ; Tumor Microenvironment/drug effects
SCR Protocol :
Folfox protocol; IFL protocol
Czasopismo naukowe
Tytuł :
Volumetric assessment of the periablational safety margin after thermal ablation of colorectal liver metastases.
Autorzy :
Laimer G; Interventional Oncology-Microinvasive Therapy (SIP), Department of Radiology, Medical University Innsbruck, Anichstr. 35, 6020, Innsbruck, Austria.
Jaschke N; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University Innsbruck, Anichstr. 35, 6020, Innsbruck, Austria.; Division of Endocrinology and Metabolic Bone Diseases, Department of Medicine III, Technical University of Dresden, Fetscherstr. 74, 01037, Dresden, Germany.
Schullian P; Interventional Oncology-Microinvasive Therapy (SIP), Department of Radiology, Medical University Innsbruck, Anichstr. 35, 6020, Innsbruck, Austria.
Putzer D; Interventional Oncology-Microinvasive Therapy (SIP), Department of Radiology, Medical University Innsbruck, Anichstr. 35, 6020, Innsbruck, Austria.
Eberle G; Interventional Oncology-Microinvasive Therapy (SIP), Department of Radiology, Medical University Innsbruck, Anichstr. 35, 6020, Innsbruck, Austria.
Solbiati M; R&D Unit, R.A.W. Srl, Milan, Italy.
Solbiati L; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Milan, Italy.; IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano, Milan, Italy.
Goldberg SN; Department of Radiology, Hadassah Hebrew University Medical Centre, Jerusalem, Israel.; Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Bale R; Interventional Oncology-Microinvasive Therapy (SIP), Department of Radiology, Medical University Innsbruck, Anichstr. 35, 6020, Innsbruck, Austria. .
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Źródło :
European radiology [Eur Radiol] 2021 Sep; Vol. 31 (9), pp. 6489-6499. Date of Electronic Publication: 2021 Jan 14.
Typ publikacji :
Journal Article
MeSH Terms :
Catheter Ablation*
Colorectal Neoplasms*/surgery
Liver Neoplasms*/diagnostic imaging
Liver Neoplasms*/surgery
Radiofrequency Ablation*
Adult ; Aged ; Aged, 80 and over ; Humans ; Male ; Margins of Excision ; Middle Aged ; Retrospective Studies ; Treatment Outcome
Czasopismo naukowe
Tytuł :
The DEN and CCl 4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.
Autorzy :
Uehara T; Strategic Development Department, Shionogi & Co., Osaka, Japan.
Pogribny IP; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas.
Rusyn I; Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas.
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Źródło :
Current protocols [Curr Protoc] 2021 Aug; Vol. 1 (8), pp. e211.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular*
Liver Neoplasms*
Liver Neoplasms, Experimental*/chemically induced
Animals ; Humans ; Inflammation ; Liver Cirrhosis/chemically induced ; Mice
Czasopismo naukowe
Tytuł :
Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma.
Autorzy :
Yoshimachi S; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.; Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shirakawa R; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Cao M; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Trinh DA; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Gao P; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of General and Emergency Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Sakata N; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Miyazaki K; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.; Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Goto K; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Miura T; Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Ariake K; Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Maeda S; Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Masuda K; Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Ishida M; Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Ohtsuka H; Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Unno M; Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Horiuchi H; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Aug; Vol. 112 (8), pp. 3064-3073. Date of Electronic Publication: 2021 Jun 15.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Pancreatic Ductal/*pathology
GTPase-Activating Proteins/*genetics
Liver Neoplasms/*pathology
Liver Neoplasms/*secondary
Pancreatic Neoplasms/*pathology
ral GTP-Binding Proteins/*metabolism
Animals ; CRISPR-Cas Systems ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/metabolism ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Gene Editing ; Gene Expression Regulation, Neoplastic ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Mice ; Mice, Nude ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism
SCR Disease Name :
Pancreatic Carcinoma
Czasopismo naukowe
Tytuł :
Identification of potential crucial genes associated with the pathogenesis and prognosis of liver hepatocellular carcinoma.
Autorzy :
Shi L; Department of Endocrinology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Shang X; Department of Endocrinology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Nie K; Department of Endocrinology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Lin Z; Department of Endocrinology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Zheng M; Department of Endocrinology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Wang M; Department of Endocrinology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Yuan H; Department of Endocrinology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Zhu Z; Department of Endocrinology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China .
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Źródło :
Journal of clinical pathology [J Clin Pathol] 2021 Aug; Vol. 74 (8), pp. 504-512. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Profiling*
Transcriptome*
Biomarkers, Tumor/*genetics
Carcinoma, Hepatocellular/*genetics
Liver Neoplasms/*genetics
Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/therapy ; Clinical Decision-Making ; Computational Biology ; Databases, Genetic ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Humans ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Oligonucleotide Array Sequence Analysis ; Predictive Value of Tests ; Prognosis ; Protein Interaction Maps
Czasopismo naukowe
Tytuł :
F-18 FDG perfusion PET: intraprocedural assessment of the liver tumor ablation margin.
Autorzy :
Shyn PB; Brigham and Women's Hospital, Boston, MA, USA. .; Harvard Medical School, Boston, MA, USA. .; Department of Radiology, Brigham and Women's Hospital, 75 Francis St., Boston, MA, 02115, USA. .
Cubre AJ; Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Catalano PJ; Harvard Medical School, Boston, MA, USA.; Dana Farber Cancer Institute, Boston, MA, USA.
Lee LK; Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Hyun H; Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Tuncali K; Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Seol JG; Brigham and Women's Hospital, Boston, MA, USA.
Levesque VM; Brigham and Women's Hospital, Boston, MA, USA.
Gerbaudo VH; Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Kapur T; Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Chao RT; Brigham and Women's Hospital, Boston, MA, USA.
Silverman SG; Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
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Źródło :
Abdominal radiology (New York) [Abdom Radiol (NY)] 2021 Jul; Vol. 46 (7), pp. 3437-3447. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Clinical Trial; Journal Article
MeSH Terms :
Fluorodeoxyglucose F18*
Liver Neoplasms*/diagnostic imaging
Liver Neoplasms*/surgery
Adult ; Aged ; Humans ; Perfusion ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Ginsenoside Rk3 Suppresses Hepatocellular Carcinoma Development through Targeting the Gut-Liver Axis.
Autorzy :
Qu L; Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China.; Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China.; Biotech. & Biomed. Research Institute, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China.
Ma X; Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China.; Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China.; Biotech. & Biomed. Research Institute, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China.
Fan D; Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China.; Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China.; Biotech. & Biomed. Research Institute, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China.
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2021 Sep 08; Vol. 69 (35), pp. 10121-10137. Date of Electronic Publication: 2021 Aug 20.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular*/drug therapy
Carcinoma, Hepatocellular*/genetics
Ginsenosides*
Liver Neoplasms*/drug therapy
Liver Neoplasms*/genetics
Animals ; Mice
Czasopismo naukowe
Tytuł :
Frailty Can Predict Prognosis After Hepatectomy in Patients With Colorectal Liver Metastasis.
Autorzy :
Tokuda K; Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Morine Y; Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan .
Miyazaki K; Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Yamada S; Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Saito YU; Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Nishi M; Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Ikemoto T; Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Shimada M; Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Sep; Vol. 41 (9), pp. 4637-4644.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Colorectal Neoplasms/*surgery
Frailty/*epidemiology
Hepatectomy/*methods
Liver Neoplasms/*secondary
Liver Neoplasms/*surgery
Neoplasm Recurrence, Local/*epidemiology
Adult ; Aged ; Aged, 80 and over ; Colorectal Neoplasms/drug therapy ; Drug Therapy ; Female ; Frailty/complications ; Humans ; Liver Neoplasms/drug therapy ; Male ; Middle Aged ; Multivariate Analysis ; Prognosis ; Retrospective Studies ; Survival Analysis ; Treatment Outcome
Czasopismo naukowe
Tytuł :
How to Perform Curative Laparoscopic Hepatectomy for Intraoperatively Unidentified Hepatocellular Carcinoma.
Autorzy :
Tsunematsu M; Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Onda S; Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan .
Yanagaki M; Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Okui N; Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Uwagawa T; Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Yasuda J; Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Furukawa K; Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Haruki K; Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Gocho T; Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Toyama Y; Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Ikegami T; Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Sep; Vol. 41 (9), pp. 4411-4416. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular/*pathology
Carcinoma, Hepatocellular/*surgery
Liver Cirrhosis/*pathology
Liver Cirrhosis/*surgery
Liver Neoplasms/*pathology
Liver Neoplasms/*surgery
Aged ; Carcinoma, Hepatocellular/diagnostic imaging ; Female ; Gadolinium DTPA/administration & dosage ; Hepatectomy ; Humans ; Indocyanine Green/administration & dosage ; Laparoscopy ; Liver Cirrhosis/diagnostic imaging ; Liver Neoplasms/diagnostic imaging ; Magnetic Resonance Imaging, Interventional ; Male ; Middle Aged ; Tumor Burden ; Ultrasonography, Interventional
Czasopismo naukowe
Tytuł :
[Residual risk of liver disease after hepatitis C virus eradication].
Autorzy :
Ongaro M; Service de gastroentérologie et hépatologie, HUG, 1211 Genève 14.
Mathys P; Service de gastroentérologie et hépatologie, HUG, 1211 Genève 14.
Zampaglione L; Service de gastroentérologie et hépatologie, HUG, 1211 Genève 14.
Negro F; Service de gastroentérologie et hépatologie, HUG, 1211 Genève 14.; Service de pathologie clinique, HUG, 1211 Genève 14.
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Transliterated Title :
Risque résiduel d’hépatopathie après éradication du virus de l’hépatite C par les antiviraux directs.
Źródło :
Revue medicale suisse [Rev Med Suisse] 2021 Sep 01; Vol. 17 (748), pp. 1453-1456.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular*/epidemiology
Carcinoma, Hepatocellular*/etiology
Hepatitis C*/complications
Hepatitis C*/drug therapy
Hepatitis C*/epidemiology
Hepatitis C, Chronic*/complications
Hepatitis C, Chronic*/drug therapy
Hepatitis C, Chronic*/epidemiology
Liver Neoplasms*/epidemiology
Liver Neoplasms*/etiology
Antiviral Agents/therapeutic use ; Hepacivirus ; Humans ; Liver Cirrhosis/drug therapy
Czasopismo naukowe
Tytuł :
Determination of therapeutic agents efficiencies of microsatellite instability high colon cancer cells in post-metastatic liver biochip modeling.
Autorzy :
Bayir Garbioglu D; Faculty of Medicine, Department of Medical Oncology, Eskisehir Osmangazi University, Eskisehir, Turkey.
Demir N; Faculty of Medicine, Department of Medical Oncology, Eskisehir Osmangazi University, Eskisehir, Turkey.
Ozel C; Cellular Therapy and Stem Cell Production Application and Research Centre, ESTEM, Eskisehir Osmangazi University, Eskisehir, Turkey.; Department of Stem Cell, Institute of Health Sciences, Eskisehir Osmangazi University, Eskisehir, Turkey.
Avci H; Cellular Therapy and Stem Cell Production Application and Research Centre, ESTEM, Eskisehir Osmangazi University, Eskisehir, Turkey.; Department of Stem Cell, Institute of Health Sciences, Eskisehir Osmangazi University, Eskisehir, Turkey.; Metallurgical and Materials Engineering, Eskisehir Osmangazi University, Eskisehir, Turkey.
Dincer M; Faculty of Medicine, Department of Medical Oncology, Eskisehir Osmangazi University, Eskisehir, Turkey.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Sep; Vol. 35 (9), pp. e21834.
Typ publikacji :
Journal Article
MeSH Terms :
Lab-On-A-Chip Devices*
Microsatellite Instability*
Colonic Neoplasms/*drug therapy
Colonic Neoplasms/*genetics
Liver Neoplasms/*drug therapy
Liver Neoplasms/*genetics
Neoplasm Metastasis/*drug therapy
Neoplasm Metastasis/*genetics
Antineoplastic Agents/therapeutic use ; Chemotherapy, Adjuvant ; Colonic Neoplasms/pathology ; Drug Screening Assays, Antitumor ; Fluorouracil/therapeutic use ; Humans ; Liver/drug effects ; Liver/immunology ; Liver/pathology ; Liver Neoplasms/secondary ; Models, Biological ; Neoplasm Metastasis/pathology ; Organ Specificity ; Oxaliplatin/therapeutic use
Czasopismo naukowe
Tytuł :
Letter: Hepatitis B and MAFLD - a consilience of risk factors for hepatocellular carcinoma.
Autorzy :
Zheng KI; NAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Zheng MH; NAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Institute of Hepatology, Wenzhou Medical University, Wenzhou, China.; The Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China.
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Źródło :
Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2021 Sep; Vol. 54 (5), pp. 736-737.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Carcinoma, Hepatocellular*/epidemiology
Carcinoma, Hepatocellular*/etiology
Hepatitis B*/complications
Hepatitis B*/epidemiology
Liver Neoplasms*/epidemiology
Liver Neoplasms*/etiology
Hepatitis B e Antigens ; Humans ; Risk Factors
Raport
Tytuł :
Editorial: central obesity is a risk factor for hepatocellular carcinoma in Asian patients with chronic hepatitis B on anti-viral therapy.
Autorzy :
Yip TC; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.; Medical Data Analytics Centre (MDAC), The Chinese University of Hong Kong, Hong Kong SAR, China.; Institute of Digestive Disease, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Wong VW; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.; Medical Data Analytics Centre (MDAC), The Chinese University of Hong Kong, Hong Kong SAR, China.; Institute of Digestive Disease, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
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Źródło :
Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2021 Sep; Vol. 54 (5), pp. 722-723.
Typ publikacji :
Editorial; Comment
MeSH Terms :
Carcinoma, Hepatocellular*/drug therapy
Carcinoma, Hepatocellular*/epidemiology
Carcinoma, Hepatocellular*/etiology
Hepatitis B, Chronic*/complications
Hepatitis B, Chronic*/drug therapy
Hepatitis B, Chronic*/epidemiology
Liver Neoplasms*/drug therapy
Liver Neoplasms*/epidemiology
Obesity, Abdominal*
Antiviral Agents/adverse effects ; Humans ; Risk Factors
Opinia redakcyjna

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