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Wyszukujesz frazę ""Molecular Targeted Therapy"" wg kryterium: Temat


Tytuł :
Aurora B kinase: a potential drug target for cancer therapy.
Autorzy :
Ahmed A; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India.
Shamsi A; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India.
Mohammad T; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India.
Hasan GM; Department of Biochemistry, College of Medicine, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj, 11942, Kingdom of Saudi Arabia.
Islam A; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India.
Hassan MI; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India. .
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Aug; Vol. 147 (8), pp. 2187-2198. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Molecular Targeted Therapy*/methods
Molecular Targeted Therapy*/trends
Aurora Kinase B/*physiology
Neoplasms/*therapy
Animals ; Antineoplastic Agents/therapeutic use ; Aurora Kinase B/antagonists & inhibitors ; Aurora Kinase B/genetics ; Cell Cycle/genetics ; Chromosomes/genetics ; Chromosomes/metabolism ; Disease Progression ; Humans ; Mitosis/genetics ; Neoplasms/etiology ; Neoplasms/pathology
Czasopismo naukowe
Tytuł :
hTERT-molecular targeted therapy of ovarian cancer cells via folate-functionalized PLGA nanoparticles co-loaded with MNPs/siRNA/wortmannin.
Autorzy :
Ghareghomi S; Department of Biochemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
Ahmadian S; Department of Biochemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran. Electronic address: .
Zarghami N; Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Hemmati S; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
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Źródło :
Life sciences [Life Sci] 2021 Jul 15; Vol. 277, pp. 119621. Date of Electronic Publication: 2021 May 15.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Delivery Systems*
Molecular Targeted Therapy*
Magnetic Iron Oxide Nanoparticles/*chemistry
Ovarian Neoplasms/*drug therapy
Polylactic Acid-Polyglycolic Acid Copolymer/*chemistry
RNA, Small Interfering/*genetics
Telomerase/*antagonists & inhibitors
Wortmannin/*pharmacology
Female ; Folic Acid/chemistry ; Humans ; Immunosuppressive Agents/pharmacology ; Nanoparticles/chemistry ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Telomerase/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Imaging and treatment of brain tumors through molecular targeting: Recent clinical advances.
Autorzy :
Zaccagna F; Division of Neuroimaging, Department of Medical Imaging, University of Toronto, Toronto, Canada. Electronic address: .
Grist JT; Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom; Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.
Quartuccio N; Nuclear Medicine Unit, A.R.N.A.S. Ospedali Civico Di Cristina Benfratelli, Palermo, Italy.
Riemer F; Mohn Medical Imaging and Visualization Centre, University of Bergen, Bergen, Norway; Department of Radiology, Haukeland University Hospital, Bergen, Norway.
Fraioli F; Institute of Nuclear Medicine, University College London, London, United Kingdom; NIHR University College London Hospitals Biomedical Research Centre, London, United Kingdom.
Caracò C; Department of Radiology, University of Cambridge, Cambridge, United Kingdom.
Halsey R; Institute of Nuclear Medicine, University College London, London, United Kingdom; NIHR University College London Hospitals Biomedical Research Centre, London, United Kingdom.
Aldalilah Y; Institute of Nuclear Medicine, University College London, London, United Kingdom; NIHR University College London Hospitals Biomedical Research Centre, London, United Kingdom; Department of Radiology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Cunningham CH; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Massoud TF; Division of Neuroimaging and Neurointervention, Department of Radiology, Stanford University School of Medicine, Stanford, USA.
Aloj L; Department of Radiology, University of Cambridge, Cambridge, United Kingdom; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
Gallagher FA; Department of Radiology, University of Cambridge, Cambridge, United Kingdom; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
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Źródło :
European journal of radiology [Eur J Radiol] 2021 Sep; Vol. 142, pp. 109842. Date of Electronic Publication: 2021 Jul 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Brain Neoplasms*/diagnostic imaging
Brain Neoplasms*/therapy
Molecular Targeted Therapy*
Humans ; Magnetic Resonance Imaging ; Positron-Emission Tomography ; Tomography, X-Ray Computed
Czasopismo naukowe
Tytuł :
Wnt/β-catenin signaling pathway in uterine leiomyoma: role in tumor biology and targeting opportunities.
Autorzy :
El Sabeh M; Department of Gynecology & Obstetrics, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD, 21205, USA.
Saha SK; Department of Gynecology & Obstetrics, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD, 21205, USA.
Afrin S; Department of Gynecology & Obstetrics, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD, 21205, USA.
Islam MS; Department of Gynecology & Obstetrics, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD, 21205, USA.
Borahay MA; Department of Gynecology & Obstetrics, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD, 21205, USA. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Sep; Vol. 476 (9), pp. 3513-3536. Date of Electronic Publication: 2021 May 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Molecular Targeted Therapy*
Antineoplastic Agents/*therapeutic use
Leiomyoma/*drug therapy
Uterine Neoplasms/*drug therapy
Wnt Signaling Pathway/*drug effects
Animals ; Female ; Humans ; Leiomyoma/metabolism ; Leiomyoma/pathology ; Uterine Neoplasms/metabolism ; Uterine Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Current updates on precision therapy for breast cancer associated brain metastasis: Emphasis on combination therapy.
Autorzy :
Raza M; Precision NeuroOncology & NeuroVascular Disease Modeling Group, Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Delhi NCR, India.
Kumar N; Precision NeuroOncology & NeuroVascular Disease Modeling Group, Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Delhi NCR, India.
Nair U; Department of Women's and Reproductive Health, Oxford Fertility, Oxford Business Park North, University of Oxford, Oxford, OX4 2HW, UK.
Luthra G; Precision NeuroOncology & NeuroVascular Disease Modeling Group, Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Delhi NCR, India.
Bhattacharyya U; Precision NeuroOncology & NeuroVascular Disease Modeling Group, Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Delhi NCR, India.
Jayasundar S; Precision NeuroOncology & NeuroVascular Disease Modeling Group, Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Delhi NCR, India.
Jayasundar R; Department of Nuclear Magnetic Resonance & MRI, All India Institute of Medical Sciences, New Delhi, 110029, India.
Sehrawat S; Precision NeuroOncology & NeuroVascular Disease Modeling Group, Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Delhi NCR, India. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Sep; Vol. 476 (9), pp. 3271-3284. Date of Electronic Publication: 2021 Apr 22.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Molecular Targeted Therapy*
Precision Medicine*
Antineoplastic Agents/*therapeutic use
Brain Neoplasms/*drug therapy
Breast Neoplasms/*drug therapy
Receptor, ErbB-2/*antagonists & inhibitors
Animals ; Brain Neoplasms/metabolism ; Brain Neoplasms/secondary ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Drug Therapy, Combination ; Female ; Humans
Czasopismo naukowe
Tytuł :
Targeting key transcriptional factor STAT3 in colorectal cancer.
Autorzy :
Chalikonda G; Internal Medicine, University of Nevada, Reno, NV-89502, USA.
Lee H; NanoBio High-Tech Materials Research Center, Department of Biological Engineering, Inha University, Incheon, 22212, Republic of Korea.
Sheik A; NanoBio High-Tech Materials Research Center, Department of Biological Engineering, Inha University, Incheon, 22212, Republic of Korea. .
Huh YS; NanoBio High-Tech Materials Research Center, Department of Biological Engineering, Inha University, Incheon, 22212, Republic of Korea. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Sep; Vol. 476 (9), pp. 3219-3228. Date of Electronic Publication: 2021 Apr 18.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Molecular Targeted Therapy*
Antineoplastic Agents/*therapeutic use
Colorectal Neoplasms/*drug therapy
STAT3 Transcription Factor/*antagonists & inhibitors
Animals ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Humans
Czasopismo naukowe
Tytuł :
TRP channels in COVID-19 disease: Potential targets for prevention and treatment.
Autorzy :
Jaffal SM; Department of Biological Sciences, Faculty of Science, The University of Jordan, 11942, Amman, Jordan. Electronic address: .
Abbas MA; Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, 19328, Amman, Jordan; Pharmacological and Diagnostic Research Center, Al-Ahliyya Amman University, 19328, Amman, Jordan.
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Aug 25; Vol. 345, pp. 109567. Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Molecular Targeted Therapy*
COVID-19/*drug therapy
COVID-19/*prevention & control
Transient Receptor Potential Channels/*metabolism
COVID-19/metabolism ; Humans
Czasopismo naukowe
Tytuł :
The anti-inflammatory effect of ε-viniferin by specifically targeting formyl peptide receptor 1 on human neutrophils.
Autorzy :
Liao HR; Graduate Institute of Natural Products, College of Medicine, Chang-Gung University, Tao Yuan, Taiwan, Republic of China; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kwei-Shan, Taoyuan, 333, Taiwan, Republic of China; Department of Anesthesiology, Chang Gung Memorial Hospital, Linkou, Taiwan, Republic of China. Electronic address: .
Lin CH; Graduate Institute of Natural Products, College of Medicine, Chang-Gung University, Tao Yuan, Taiwan, Republic of China.
Chen JJ; Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan, Republic of China; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, Republic of China.
Liu FC; Department of Anesthesiology, Chang Gung Memorial Hospital, Linkou, Taiwan, Republic of China.
Tseng CP; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kwei-Shan, Taoyuan, 333, Taiwan, Republic of China; Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Kwei Shan, Taoyuan, 333, Taiwan, Republic of China; Molecular Medicine Research Center, Chang Gung University, Kwei Shan, Taoyuan, 333, Taiwan, Republic of China; Department of Laboratory Medicine, Chang Gung Memorial Hospital, Kwei Shan, Taoyuan, 333, Taiwan, Republic of China.
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Aug 25; Vol. 345, pp. 109490. Date of Electronic Publication: 2021 Jun 16.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Targeted Therapy*
Anti-Inflammatory Agents/*pharmacology
Benzofurans/*pharmacology
Neutrophils/*drug effects
Neutrophils/*metabolism
Receptors, Formyl Peptide/*antagonists & inhibitors
Stilbenes/*pharmacology
Amino Acid Sequence ; Calcium/metabolism ; Dose-Response Relationship, Drug ; Drug Synergism ; Humans ; Oligopeptides/chemistry ; Oligopeptides/pharmacology ; Superoxides/metabolism
Czasopismo naukowe
Tytuł :
Breast Cancer Targeting of a Drug Delivery System through Postsynthetic Modification of Curcumin@N 3 -bio-MOF-100 via Click Chemistry.
Autorzy :
Alves RC; Department of Drugs and Medicines, School of Pharmaceutical Sciences of São Paulo State University (UNESP), Rodovia Araraquara Jaú, Km 01 - s/n - Campos Ville, 14800-903 Araraquara, São Paulo, Brazil.
Schulte ZM; Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 1560, United States.
Luiz MT; Department of Pharmaceutical Sciences, School of Pharmaceutical Science of Ribeirão Preto, University of São Paulo (USP), Avenida do Café, s/n - Campus da USP, 14040-903 Ribeirão Preto, Sao Paulo, Brazil.
Bento da Silva P; Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia (UnB), Campus Universitario Darcy Ribeiro - Asa Norte, 70910-900 Brasilia, Federal District, Brazil.
Frem RCG; Institute of Chemistry, São Paulo State University (UNESP), Prof. Francisco Degni 55, PO Box 355, 14800-970 Araraquara, São Paulo, Brazil.
Rosi NL; Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 1560, United States.
Chorilli M; Department of Drugs and Medicines, School of Pharmaceutical Sciences of São Paulo State University (UNESP), Rodovia Araraquara Jaú, Km 01 - s/n - Campos Ville, 14800-903 Araraquara, São Paulo, Brazil.
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Źródło :
Inorganic chemistry [Inorg Chem] 2021 Aug 16; Vol. 60 (16), pp. 11739-11744. Date of Electronic Publication: 2021 Jun 08.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Targeted Therapy*
Breast Neoplasms/*drug therapy
Curcumin/*chemistry
Drug Carriers/*chemistry
Metal-Organic Frameworks/*chemistry
Click Chemistry ; Curcumin/pharmacology ; Curcumin/therapeutic use ; Folic Acid/chemistry
Czasopismo naukowe
Tytuł :
eEF2K: an atypical kinase target for cancer.
Autorzy :
Temme L
Asquith CRM
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Źródło :
Nature reviews. Drug discovery [Nat Rev Drug Discov] 2021 Aug; Vol. 20 (8), pp. 577.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Targeted Therapy*
Elongation Factor 2 Kinase/*antagonists & inhibitors
Neoplasms/*drug therapy
Protein Kinase Inhibitors/*therapeutic use
Humans ; Neoplasms/enzymology ; Neoplasms/pathology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Hemagglutinin-esterase cannot be considered as a candidate for designing drug against COVID-19.
Autorzy :
Zandi M; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. .; Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran. .
Soltani S; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.; Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran.
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Źródło :
Molecular diversity [Mol Divers] 2021 Aug; Vol. 25 (3), pp. 1999-2000. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Letter
MeSH Terms :
Drug Design*
Molecular Targeted Therapy*
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Antiviral Agents/therapeutic use ; COVID-19/genetics ; COVID-19/metabolism ; Genome, Viral/genetics ; Hemagglutinins, Viral/genetics ; Hemagglutinins, Viral/metabolism ; Viral Fusion Proteins/genetics ; Viral Fusion Proteins/metabolism
Opinia redakcyjna
Tytuł :
Noncoding RNA therapeutics - challenges and potential solutions.
Autorzy :
Winkle M; Translational Molecular Pathology, MD Anderson Cancer Center, Texas State University, Houston, TX, USA.
El-Daly SM; Medical Biochemistry Department, Medical Research Division - Cancer Biology and Genetics Laboratory, Centre of Excellence for Advanced Sciences - National Research Centre, Cairo, Egypt.
Fabbri M; Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Calin GA; Translational Molecular Pathology, MD Anderson Cancer Center, Texas State University, Houston, TX, USA. .; The RNA Interference and Non-codingRNA Center, MD Anderson Cancer Center, Texas State University, Houston, TX, USA. .
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Źródło :
Nature reviews. Drug discovery [Nat Rev Drug Discov] 2021 Aug; Vol. 20 (8), pp. 629-651. Date of Electronic Publication: 2021 Jun 18.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Molecular Targeted Therapy*
Genetic Therapy/*methods
Neoplasms/*therapy
RNA, Long Noncoding/*genetics
Animals ; Humans ; Neoplasms/genetics
Czasopismo naukowe
Tytuł :
Overview of key molecular and pharmacological targets for diabetes and associated diseases.
Autorzy :
Shahcheraghi SH; Infectious Diseases Research Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Aljabali AAA; Department of Pharmaceutics & Pharmaceutical Technology, Yarmouk University, Irbid, Jordan.
Al Zoubi MS; Yarmouk University, Faculty of Medicine, Department of Basic Medical Sciences, Irbid, Jordan.
Mishra V; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, Punjab, India.
Charbe NB; Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, TX 78363, USA.
Haggag YA; Department of Pharmaceutical Technology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Shrivastava G; Indian Institute of Technology, Delhi, India.
Almutary AG; Department of Medical Biotechnology, College of Applied Medical Sciences, Qassim University, Saudi Arabia.
Alnuqaydan AM; Department of Medical Biotechnology, College of Applied Medical Sciences, Qassim University, Saudi Arabia.
Barh D; Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied, India.
Dua K; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Chellappan DK; Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia.
Gupta G; School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India.
Lotfi M; Abortion Research Center, Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address: .
Serrano-Aroca Á; Biomaterials and Bioengineering Lab, Translational Research Centre San Alberto Magno, Catholic University of Valencia San Vicente Mártir, C/Guillem de Castro 94, 46001 Valencia, Spain.
Bahar B; Nutrition Sciences and Applied Food Safety Studies, Research Centre for Global Development, School of Sport & Health Sciences, University of Central Lancashire, Preston, PR1 2HE, UK.
Mishra YK; University of Southern Denmark, Mads Clausen Institute, NanoSYD, Alsion 2, 6400 Sønderborg, Denmark.
Takayama K; Center for IPS Cell Research and Application, Kyoto University, Kyoto, 606-8397, Japan.
Panda PK; Condensed Matter Theory Group, Materials Theory Division, Department of Physics and Astronomy, Uppsala University, Box 516, 75120 Uppsala, Sweden.
Bakshi HA; School of Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, County Londonderry, BT52 1SA, Northern Ireland, United Kingdom.
Tambuwala MM; School of Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, County Londonderry, BT52 1SA, Northern Ireland, United Kingdom. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Aug 01; Vol. 278, pp. 119632. Date of Electronic Publication: 2021 May 18.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Discovery*
Molecular Targeted Therapy*
Diabetes Complications/*drug therapy
Diabetes Mellitus/*drug therapy
Signal Transduction/*drug effects
Animals ; Diabetes Complications/genetics ; Diabetes Complications/metabolism ; Diabetes Complications/pathology ; Diabetes Mellitus/genetics ; Diabetes Mellitus/metabolism ; Diabetes Mellitus/pathology ; Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use
Czasopismo naukowe
Tytuł :
Blood tests predict the therapeutic prognosis of anti-PD-1 in advanced biliary tract cancer.
Autorzy :
Du F; Department of Laboratory Medicine, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Qiu Z; Department of Biliary Tract Surgery I, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Ai W; Department of Laboratory Medicine, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Huang C; Department of Laboratory Medicine, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Ji J; Department of Laboratory Medicine, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Xiao X; Department of Laboratory Medicine, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Zhou J; Department of Laboratory Medicine, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Fang M; Department of Laboratory Medicine, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Jiang X; Department of Biliary Tract Surgery I, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Gao C; Department of Laboratory Medicine, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Aug; Vol. 110 (2), pp. 327-334. Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Targeted Therapy*
Biliary Tract Neoplasms/*blood
Biliary Tract Neoplasms/*drug therapy
Biomarkers/*blood
Immune Checkpoint Inhibitors/*therapeutic use
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Biliary Tract Neoplasms/mortality ; Cytokines/blood ; Cytokines/metabolism ; Humans ; Immune Checkpoint Inhibitors/administration & dosage ; Immune Checkpoint Inhibitors/adverse effects ; Immunoassay ; Leukocyte Count ; Nomograms ; Prognosis ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Therapeutic potential of AMPK signaling targeting in lung cancer: Advances, challenges and future prospects.
Autorzy :
Ashrafizadeh M; Faculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Üniversite Caddesi No. 27, Orhanlı, Tuzla, 34956 Istanbul, Turkey; Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, 34956, Istanbul, Turkey.
Mirzaei S; Department of Biology, Faculty of Science, Islamic Azad University, Science and Research Branch, Tehran, Iran.
Hushmandi K; Department of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Rahmanian V; Research Center for Social Determinants of Health, Jahrom University of Medical Sciences, Jahrom, Iran.
Zabolian A; Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Raei M; Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Farahani MV; Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Goharrizi MASB; Atherosclerosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Khan H; Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan.
Zarrabi A; Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, 34956, Istanbul, Turkey. Electronic address: .
Samarghandian S; Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Aug 01; Vol. 278, pp. 119649. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Molecular Targeted Therapy*
AMP-Activated Protein Kinases/*metabolism
Antineoplastic Agents/*pharmacology
Lung Neoplasms/*drug therapy
Signal Transduction/*drug effects
Animals ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Energy Metabolism/drug effects ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Targeted Therapies in Rare Brain Tumours.
Autorzy :
Bruno F; Department Neuro-Oncology, University and City of Health and Science, 10126 Turin, Italy.
Pellerino A; Department Neuro-Oncology, University and City of Health and Science, 10126 Turin, Italy.
Bertero L; Pathology Unit, Department of Medical Sciences, University and City of Health and Science, 10126 Turin, Italy.
Soffietti R; Department Neuro-Oncology, University and City of Health and Science, 10126 Turin, Italy.
Rudà R; Department Neuro-Oncology, University and City of Health and Science, 10126 Turin, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 26; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 26.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Brain Neoplasms*/genetics
Brain Neoplasms*/metabolism
Brain Neoplasms*/therapy
Molecular Targeted Therapy*
Mutation*
Neoplasm Proteins*/genetics
Neoplasm Proteins*/metabolism
Rare Diseases*/genetics
Rare Diseases*/metabolism
Rare Diseases*/therapy
Signal Transduction*
Humans
Czasopismo naukowe
Tytuł :
Genomic Variability in the Survival Motor Neuron Genes ( SMN1 and SMN2 ): Implications for Spinal Muscular Atrophy Phenotype and Therapeutics Development.
Autorzy :
Butchbach MER; Center for Applied Clinical Genomics, Nemours Children's Health Delaware, Wilmington, DE 19803, USA.; Center for Pediatric Research, Nemours Children's Health Delaware, Wilmington, DE 19803, USA.; Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA.; Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA 19107, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 23; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genetic Therapy*
Genetic Variation*
Molecular Targeted Therapy*
Muscular Atrophy, Spinal/*pathology
Survival of Motor Neuron 1 Protein/*genetics
Humans ; Muscular Atrophy, Spinal/genetics ; Muscular Atrophy, Spinal/therapy ; Survival of Motor Neuron 2 Protein/genetics
Czasopismo naukowe
Tytuł :
Oral Selective Estrogen Receptor Degraders (SERDs) as a Novel Breast Cancer Therapy: Present and Future from a Clinical Perspective.
Autorzy :
Hernando C; Hospital Clínico de València, Instituto de Investigación INCLIVA, 46010 Valencia, Spain.
Ortega-Morillo B; Hospital Clínico de València, Instituto de Investigación INCLIVA, 46010 Valencia, Spain.
Tapia M; Hospital Clínico de València, Instituto de Investigación INCLIVA, 46010 Valencia, Spain.
Moragón S; Hospital Clínico de València, Instituto de Investigación INCLIVA, 46010 Valencia, Spain.
Martínez MT; Hospital Clínico de València, Instituto de Investigación INCLIVA, 46010 Valencia, Spain.
Eroles P; Hospital Clínico de València, Instituto de Investigación INCLIVA, 46010 Valencia, Spain.; Centro de Investigación Biomédica en Red de Oncología, CIBERONC-ISCIII, 28029 Madrid, Spain.; Departamento de Fisiología, Universidad de València, 46010 Valencia, Spain.
Garrido-Cano I; Hospital Clínico de València, Instituto de Investigación INCLIVA, 46010 Valencia, Spain.
Adam-Artigues A; Hospital Clínico de València, Instituto de Investigación INCLIVA, 46010 Valencia, Spain.
Lluch A; Hospital Clínico de València, Instituto de Investigación INCLIVA, 46010 Valencia, Spain.; Centro de Investigación Biomédica en Red de Oncología, CIBERONC-ISCIII, 28029 Madrid, Spain.
Bermejo B; Hospital Clínico de València, Instituto de Investigación INCLIVA, 46010 Valencia, Spain.; Centro de Investigación Biomédica en Red de Oncología, CIBERONC-ISCIII, 28029 Madrid, Spain.
Cejalvo JM; Hospital Clínico de València, Instituto de Investigación INCLIVA, 46010 Valencia, Spain.; Centro de Investigación Biomédica en Red de Oncología, CIBERONC-ISCIII, 28029 Madrid, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 22; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Molecular Targeted Therapy*
Breast Neoplasms/*drug therapy
Receptors, Estrogen/*metabolism
Selective Estrogen Receptor Modulators/*therapeutic use
Animals ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Female ; Humans
Czasopismo naukowe
Tytuł :
New Insights into Cancer Targeted Therapy: Nodal and Cripto-1 as Attractive Candidates.
Autorzy :
Arboretto P; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy.
Cillo M; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy.
Leonardi A; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 22; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Molecular Targeted Therapy*
Antineoplastic Agents/*therapeutic use
GPI-Linked Proteins/*antagonists & inhibitors
Neoplasms/*drug therapy
Nodal Protein/*antagonists & inhibitors
Animals ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology
Czasopismo naukowe
Tytuł :
The Neurotrophin Receptor TrkC as a Novel Molecular Target of the Antineuroblastoma Action of Valproic Acid.
Autorzy :
Dedoni S; Laboratory of Cellular and Molecular Pharmacology, Section of Neurosciences, University of Cagliari, 09042 Monserrato, Italy.
Marras L; Section of Microbiology, Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy.
Olianas MC; Laboratory of Cellular and Molecular Pharmacology, Section of Neurosciences, University of Cagliari, 09042 Monserrato, Italy.
Ingianni A; Section of Microbiology, Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy.
Onali P; Laboratory of Cellular and Molecular Pharmacology, Section of Neurosciences, University of Cagliari, 09042 Monserrato, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 21; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Targeted Therapy*
Anticonvulsants/*pharmacology
Gene Expression Regulation, Neoplastic/*drug effects
Neuroblastoma/*drug therapy
Receptor, trkC/*metabolism
Valproic Acid/*pharmacology
Apoptosis ; Cell Proliferation ; Humans ; Neuroblastoma/genetics ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; Receptor, trkC/genetics ; Tumor Cells, Cultured
Czasopismo naukowe

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