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Tytuł :
Expanding the binding specificity for RNA recognition by a PUF domain.
Autorzy :
Zhou W; Department of Genome Sciences, University of Washington, Seattle, Washington, USA.; Molecular and Cellular Biology Program, University of Washington, Seattle, Washington, USA.; The Rockefeller University, New York, NY, USA.
Melamed D; Department of Genome Sciences, University of Washington, Seattle, Washington, USA.; Department of Evolutionary and Environmental Biology, University of Haifa, Haifa, Israel.; Institute of Evolution, University of Haifa, Haifa, Israel.
Banyai G; The Rockefeller University, New York, NY, USA.
Meyer C; The Rockefeller University, New York, NY, USA.
Tuschl T; The Rockefeller University, New York, NY, USA.
Wickens M; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Cao J; The Rockefeller University, New York, NY, USA. .
Fields S; Department of Genome Sciences, University of Washington, Seattle, Washington, USA. .; Department of Medicine, University of Washington, Seattle, Washington, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 24; Vol. 12 (1), pp. 5107. Date of Electronic Publication: 2021 Aug 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Protein Binding*
Protein Domains*
RNA/*metabolism
RNA-Binding Proteins/*metabolism
Binding Sites ; Crystallography, X-Ray ; Models, Molecular ; Protein Conformation ; RNA/chemistry ; RNA-Binding Motifs ; RNA-Binding Proteins/chemistry ; Saccharomyces cerevisiae/metabolism
Czasopismo naukowe
Tytuł :
Ultrapotent miniproteins targeting the SARS-CoV-2 receptor-binding domain protect against infection and disease.
Autorzy :
Case JB; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Chen RE; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Cao L; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Ying B; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Winkler ES; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Johnson M; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Goreshnik I; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Pham MN; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Shrihari S; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Kafai NM; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Bailey AL; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Xie X; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Shi PY; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA.
Ravichandran R; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Carter L; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Stewart L; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Baker D; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
Diamond MS; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2021 Jul 14; Vol. 29 (7), pp. 1151-1161.e5. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Binding*
COVID-19/*prevention & control
COVID-19 Vaccines/*immunology
SARS-CoV-2/*immunology
Administration, Intranasal ; Angiotensin-Converting Enzyme 2 ; Animals ; COVID-19/immunology ; COVID-19 Vaccines/administration & dosage ; Disease Models, Animal ; Female ; Humans ; Lung/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Pandemics/prevention & control ; Serine C-Palmitoyltransferase ; Spike Glycoprotein, Coronavirus/chemistry ; Viral Load
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
Distinct EH domains of the endocytic TPLATE complex confer lipid and protein binding.
Autorzy :
Yperman K; Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.; VIB Center for Plant Systems Biology, Ghent, Belgium.
Papageorgiou AC; CEITEC-Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Merceron R; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.; VIB Center for Inflammation Research, Ghent, Belgium.
De Munck S; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.; VIB Center for Inflammation Research, Ghent, Belgium.
Bloch Y; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.; VIB Center for Inflammation Research, Ghent, Belgium.
Eeckhout D; Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.; VIB Center for Plant Systems Biology, Ghent, Belgium.
Jiang Q; Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.; VIB Center for Plant Systems Biology, Ghent, Belgium.
Tack P; Department of Chemistry, X-ray Microspectroscopy and Imaging - XMI Research Unit, Ghent University, Ghent, Belgium.
Grigoryan R; Department of Chemistry, Atomic & Mass Spectrometry - A&MS Research Unit, Ghent University, Ghent, Belgium.
Evangelidis T; CEITEC-Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Van Leene J; Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.; VIB Center for Plant Systems Biology, Ghent, Belgium.
Vincze L; Department of Chemistry, X-ray Microspectroscopy and Imaging - XMI Research Unit, Ghent University, Ghent, Belgium.
Vandenabeele P; Department of Chemistry, X-ray Microspectroscopy and Imaging - XMI Research Unit, Ghent University, Ghent, Belgium.; Archaeometry Research Group, Department of Archaeology, Ghent University, Ghent, Belgium.
Vanhaecke F; Department of Chemistry, Atomic & Mass Spectrometry - A&MS Research Unit, Ghent University, Ghent, Belgium.
Potocký M; Institute of Experimental Botany, Academy of Sciences of the Czech Republic, Prague 6, Czech Republic.
De Jaeger G; Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.; VIB Center for Plant Systems Biology, Ghent, Belgium.
Savvides SN; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium. .; VIB Center for Inflammation Research, Ghent, Belgium. .
Tripsianes K; CEITEC-Central European Institute of Technology, Masaryk University, Brno, Czech Republic. .
Pleskot R; Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium. .; VIB Center for Plant Systems Biology, Ghent, Belgium. .; Institute of Experimental Botany, Academy of Sciences of the Czech Republic, Prague 6, Czech Republic. .
Van Damme D; Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium. .; VIB Center for Plant Systems Biology, Ghent, Belgium. .
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Źródło :
Nature communications [Nat Commun] 2021 May 24; Vol. 12 (1), pp. 3050. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endocytosis*
Protein Binding*
Adaptor Proteins, Signal Transducing/*chemistry
Calcium-Binding Proteins/*chemistry
Plant Proteins/*chemistry
Adaptor Proteins, Signal Transducing/genetics ; Arabidopsis Proteins ; Calcium-Binding Proteins/genetics ; Cell Membrane/metabolism ; Crystallography, X-Ray ; Membrane Proteins/chemistry ; Molecular Dynamics Simulation ; Plant Proteins/genetics ; Plants, Genetically Modified ; Protein Domains ; Protein Transport ; Sequence Alignment ; Tobacco/genetics
Czasopismo naukowe
Tytuł :
The Structure and Ubiquitin Binding Properties of TRAF RING Heterodimers.
Autorzy :
Das A; Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand.
Middleton AJ; Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand.
Padala P; Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand.
Ledgerwood EC; Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand.
Mace PD; Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand.
Day CL; Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Apr 16; Vol. 433 (8), pp. 166844. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Binding*
Ubiquitination*
Ubiquitin/*chemistry
Dimerization ; Humans ; Protein Interaction Domains and Motifs ; Receptors, Tumor Necrosis Factor/chemistry ; Receptors, Tumor Necrosis Factor/metabolism ; Signal Transduction ; TNF Receptor-Associated Factor 2/genetics ; TNF Receptor-Associated Factor 2/metabolism ; TNF Receptor-Associated Factor 3/metabolism ; TNF Receptor-Associated Factor 5/metabolism ; TNF Receptor-Associated Factor 6 ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases ; Zinc Fingers
Czasopismo naukowe
Tytuł :
DeepGRN: prediction of transcription factor binding site across cell-types using attention-based deep neural networks.
Autorzy :
Chen C; Electrical Engineering and Computer Science Department, University of Missouri, Columbia, MO, 65211, USA.
Hou J; Department of Computer Science, Saint Louis University, St. Louis, MO, 63103, USA.
Shi X; Division of Biological Sciences, University of Missouri, Columbia, MO, 65211, USA.
Yang H; Division of Biological Sciences, University of Missouri, Columbia, MO, 65211, USA.
Birchler JA; Division of Biological Sciences, University of Missouri, Columbia, MO, 65211, USA.
Cheng J; Electrical Engineering and Computer Science Department, University of Missouri, Columbia, MO, 65211, USA. .
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2021 Feb 01; Vol. 22 (1), pp. 38. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatin*
Neural Networks, Computer*
Protein Binding*
Transcription Factors*/genetics
Transcription Factors*/metabolism
Binding Sites ; Computational Biology
Czasopismo naukowe
Tytuł :
SSnet: A Deep Learning Approach for Protein-Ligand Interaction Prediction.
Autorzy :
Verma N; Department of Chemistry, Southern Methodist University, Dallas, TX 75205, USA.
Qu X; Department of Computer Science, Southern Methodist University, Dallas, TX 75205, USA.
Trozzi F; Department of Chemistry, Southern Methodist University, Dallas, TX 75205, USA.
Elsaied M; Department of Engineering Management and Information System, Southern Methodist University, Dallas, TX 75205, USA.
Karki N; Department of Chemistry, Southern Methodist University, Dallas, TX 75205, USA.
Tao Y; Department of Chemistry, Southern Methodist University, Dallas, TX 75205, USA.
Zoltowski B; Department of Chemistry, Southern Methodist University, Dallas, TX 75205, USA.
Larson EC; Department of Computer Science, Southern Methodist University, Dallas, TX 75205, USA.
Kraka E; Department of Chemistry, Southern Methodist University, Dallas, TX 75205, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 30; Vol. 22 (3). Date of Electronic Publication: 2021 Jan 30.
Typ publikacji :
Journal Article
MeSH Terms :
Deep Learning*
Ligands*
Protein Binding*
Drug Discovery/*methods
Animals ; Binding Sites ; Caenorhabditis elegans ; Datasets as Topic ; Humans ; Protein Domains ; Protein Structure, Secondary
Czasopismo naukowe
Tytuł :
Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity.
Autorzy :
Fougeroux C; AdaptVac Aps, 2970, Hørsholm, Denmark.
Goksøyr L; AdaptVac Aps, 2970, Hørsholm, Denmark.; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200, Copenhagen, Denmark.
Idorn M; Department of Biomedicine, Aarhus University, 8000, Aarhus, Denmark.
Soroka V; ExpreS2ion Biotechnologies Aps, 2970, Hørsholm, Denmark.
Myeni SK; Department of Medical Microbiology, Leiden University Medical Center, ZA, Leiden, 2333, Netherlands.
Dagil R; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200, Copenhagen, Denmark.; VAR2pharmaceuticals, 2200, Copenhagen, Denmark.
Janitzek CM; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200, Copenhagen, Denmark.
Søgaard M; ExpreS2ion Biotechnologies Aps, 2970, Hørsholm, Denmark.
Aves KL; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200, Copenhagen, Denmark.
Horsted EW; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200, Copenhagen, Denmark.
Erdoğan SM; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200, Copenhagen, Denmark.; Turkish Ministry of Agriculture and Forestry, 06800, Ankara, Turkey.
Gustavsson T; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200, Copenhagen, Denmark.; VAR2pharmaceuticals, 2200, Copenhagen, Denmark.
Dorosz J; ExpreS2ion Biotechnologies Aps, 2970, Hørsholm, Denmark.
Clemmensen S; ExpreS2ion Biotechnologies Aps, 2970, Hørsholm, Denmark.
Fredsgaard L; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200, Copenhagen, Denmark.
Thrane S; AdaptVac Aps, 2970, Hørsholm, Denmark.
Vidal-Calvo EE; VAR2pharmaceuticals, 2200, Copenhagen, Denmark.
Khalifé P; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200, Copenhagen, Denmark.
Hulen TM; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200, Copenhagen, Denmark.
Choudhary S; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200, Copenhagen, Denmark.; VAR2pharmaceuticals, 2200, Copenhagen, Denmark.
Theisen M; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200, Copenhagen, Denmark.; Department for Congenital Disorders, Statens Serum Institute, 2300, Copenhagen, Denmark.
Singh SK; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200, Copenhagen, Denmark.; Department for Congenital Disorders, Statens Serum Institute, 2300, Copenhagen, Denmark.
Garcia-Senosiain A; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200, Copenhagen, Denmark.; Department for Congenital Disorders, Statens Serum Institute, 2300, Copenhagen, Denmark.
Van Oosten L; Department of Plant Sciences, Laboratory of Virology, 6700AA, Wageningen, Netherlands.
Pijlman G; Department of Plant Sciences, Laboratory of Virology, 6700AA, Wageningen, Netherlands.
Hierzberger B; ExpreS2ion Biotechnologies Aps, 2970, Hørsholm, Denmark.
Domeyer T; ExpreS2ion Biotechnologies Aps, 2970, Hørsholm, Denmark.
Nalewajek BW; ExpreS2ion Biotechnologies Aps, 2970, Hørsholm, Denmark.
Strøbæk A; ExpreS2ion Biotechnologies Aps, 2970, Hørsholm, Denmark.
Skrzypczak M; ExpreS2ion Biotechnologies Aps, 2970, Hørsholm, Denmark.
Andersson LF; ExpreS2ion Biotechnologies Aps, 2970, Hørsholm, Denmark.
Buus S; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Danmark.
Buus AS; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Danmark.
Christensen JP; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Danmark.
Dalebout TJ; Department of Medical Microbiology, Leiden University Medical Center, ZA, Leiden, 2333, Netherlands.
Iversen K; Department of Cardiology, Herlev Hospital, 2730, Herlev, Denmark.
Harritshøj LH; Department of Clinical Immunology, Copenhagen University Hospital, 2100, Copenhagen, Denmark.
Mordmüller B; Universitätsklinikum Tübingen, Institut für Tropenmedizin, 72074, Tübingen, Germany.; Centre de Recherches Médicales de Lambaréné, BP 242, Lambaréné, Gabon.
Ullum H; Department of Cardiology, Herlev Hospital, 2730, Herlev, Denmark.
Reinert LS; Department of Biomedicine, Aarhus University, 8000, Aarhus, Denmark.
de Jongh WA; AdaptVac Aps, 2970, Hørsholm, Denmark.; ExpreS2ion Biotechnologies Aps, 2970, Hørsholm, Denmark.
Kikkert M; Department of Medical Microbiology, Leiden University Medical Center, ZA, Leiden, 2333, Netherlands.
Paludan SR; Department of Biomedicine, Aarhus University, 8000, Aarhus, Denmark.
Theander TG; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200, Copenhagen, Denmark.
Nielsen MA; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200, Copenhagen, Denmark. .
Salanti A; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200, Copenhagen, Denmark.; VAR2pharmaceuticals, 2200, Copenhagen, Denmark.
Sander AF; AdaptVac Aps, 2970, Hørsholm, Denmark. .; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200, Copenhagen, Denmark. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 12; Vol. 12 (1), pp. 324. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Neutralizing/*immunology
COVID-19 Vaccines/*immunology
Capsid/*immunology
Protein Binding/*immunology
SARS-CoV-2/*immunology
Angiotensin-Converting Enzyme 2 ; Animals ; Antibodies, Viral/immunology ; COVID-19/prevention & control ; Female ; Humans ; Immunogenicity, Vaccine ; Kinetics ; Mice ; Mice, Inbred BALB C ; Protein Binding/genetics ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology ; Serologic Tests ; Spike Glycoprotein, Coronavirus/immunology
Czasopismo naukowe
Tytuł :
MATHLA: a robust framework for HLA-peptide binding prediction integrating bidirectional LSTM and multiple head attention mechanism.
Autorzy :
Ye Y; Shenzhen Neocura Biotechnology Co. Ltd., Shenzhen, 518055, China.; School of Computer Science and Technology, Heilongjiang University, Harbin, 150080, China.
Wang J; Shenzhen Neocura Biotechnology Co. Ltd., Shenzhen, 518055, China.
Xu Y; Shenzhen Neocura Biotechnology Co. Ltd., Shenzhen, 518055, China.
Wang Y; Shenzhen Neocura Biotechnology Co. Ltd., Shenzhen, 518055, China.
Pan Y; Shenzhen Neocura Biotechnology Co. Ltd., Shenzhen, 518055, China.
Song Q; Shenzhen Neocura Biotechnology Co. Ltd., Shenzhen, 518055, China.
Liu X; The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China.
Wan J; Shenzhen Neocura Biotechnology Co. Ltd., Shenzhen, 518055, China. .
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2021 Jan 06; Vol. 22 (1), pp. 7. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article
MeSH Terms :
Histocompatibility Antigens Class I*/chemistry
Histocompatibility Antigens Class I*/metabolism
Neural Networks, Computer*
Peptides*/chemistry
Peptides*/metabolism
Protein Binding*
Computational Biology/*methods
Algorithms ; Humans ; Models, Statistical
Czasopismo naukowe
Tytuł :
Stability and Folding of the Unusually Stable Hemoglobin from Synechocystis is Subtly Optimized and Dependent on the Key Heme Pocket Residues.
Autorzy :
Uppal S; Department of Biochemistry, University of Delhi South Campus, New Delhi, 110021, India.
Khan MA; Department of Biochemistry, University of Delhi South Campus, New Delhi, 110021, India.
Kundu S; Department of Biochemistry, University of Delhi South Campus, New Delhi, 110021, India.
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Źródło :
Protein and peptide letters [Protein Pept Lett] 2021; Vol. 28 (2), pp. 164-182.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Binding*
Hemoglobins/*chemistry
Hemoglobins/*metabolism
Histidine/*chemistry
Histidine/*metabolism
Synechocystis/*metabolism
Hemoglobins/genetics ; Histidine/genetics ; Humans ; Models, Molecular ; Mutation ; Protein Conformation ; Protein Folding ; Protein Stability ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
Czasopismo naukowe
Tytuł :
Calmodulin binding transcription activators: An interplay between calcium signalling and plant stress tolerance.
Autorzy :
Noman M; College of Life Sciences, Engineering Research Centre of the Chinese Ministry of Education for Bioreactor and Pharmaceutical Development, Jilin Agricultural University, 2888 Xincheng Street, Changchun, Jilin Province 130118, PR China. Electronic address: .
Aysha J; College of Life Sciences, Engineering Research Centre of the Chinese Ministry of Education for Bioreactor and Pharmaceutical Development, Jilin Agricultural University, 2888 Xincheng Street, Changchun, Jilin Province 130118, PR China.
Ketehouli T; College of Life Sciences, Engineering Research Centre of the Chinese Ministry of Education for Bioreactor and Pharmaceutical Development, Jilin Agricultural University, 2888 Xincheng Street, Changchun, Jilin Province 130118, PR China.
Yang J; College of Life Sciences, Engineering Research Centre of the Chinese Ministry of Education for Bioreactor and Pharmaceutical Development, Jilin Agricultural University, 2888 Xincheng Street, Changchun, Jilin Province 130118, PR China.
Du L; College of Life Sciences, Engineering Research Centre of the Chinese Ministry of Education for Bioreactor and Pharmaceutical Development, Jilin Agricultural University, 2888 Xincheng Street, Changchun, Jilin Province 130118, PR China.
Wang F; College of Life Sciences, Engineering Research Centre of the Chinese Ministry of Education for Bioreactor and Pharmaceutical Development, Jilin Agricultural University, 2888 Xincheng Street, Changchun, Jilin Province 130118, PR China.
Li H; College of Tropical Crops, Hainan University, 570228, Haikou, China. Electronic address: .
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Źródło :
Journal of plant physiology [J Plant Physiol] 2021 Jan; Vol. 256, pp. 153327. Date of Electronic Publication: 2020 Nov 22.
Typ publikacji :
Journal Article
MeSH Terms :
Arabidopsis/*genetics
Arabidopsis/*physiology
Calmodulin/*genetics
Calmodulin/*metabolism
Protein Binding/*physiology
Signal Transduction/*physiology
Stress, Physiological/*physiology
Transcription Factors/*metabolism
Gene Expression Regulation, Plant ; Protein Binding/genetics ; Signal Transduction/genetics ; Stress, Physiological/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Sample preparation techniques for protein binding measurement in radiopharmaceutical approaches: A short review.
Autorzy :
Moein MM; Karolinska Radiopharmacy, Karolinska University Hospital, S-171 64 Stockholm, Sweden; Karolinska Institutet, Department of Oncology-Pathology, J5:20, S-171 77 Stockholm, Sweden. Electronic address: .
Halldin C; Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, SE-171 76 Stockholm, Sweden.
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Źródło :
Talanta [Talanta] 2020 Nov 01; Vol. 219, pp. 121220. Date of Electronic Publication: 2020 May 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Positron-Emission Tomography*
Protein Binding*
Radiopharmaceuticals*
Blood Proteins/metabolism ; Brain/metabolism ; Prospective Studies
Czasopismo naukowe
Tytuł :
Angiotensin-converting enzyme 2 (ACE2) receptor and SARS-CoV-2: Potential therapeutic targeting.
Autorzy :
Sharifkashani S; Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Bafrani MA; Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran; Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran.
Khaboushan AS; Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Pirzadeh M; Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran; Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Kheirandish A; Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran; Student Research Committee, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Yavarpour Bali H; Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran; Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Hessami A; Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran; Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Saghazadeh A; Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran; Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Rezaei N; Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2020 Oct 05; Vol. 884, pp. 173455. Date of Electronic Publication: 2020 Jul 31.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Coronavirus Infections*/drug therapy
Coronavirus Infections*/metabolism
Coronavirus Infections*/virology
Pandemics*
Pneumonia, Viral*/drug therapy
Pneumonia, Viral*/metabolism
Pneumonia, Viral*/virology
Protein Binding*/drug effects
Protein Binding*/physiology
Betacoronavirus/*physiology
Drug Discovery/*methods
Peptidyl-Dipeptidase A/*metabolism
Spike Glycoprotein, Coronavirus/*metabolism
Virus Internalization/*drug effects
Angiotensin-Converting Enzyme 2 ; COVID-19 ; Humans ; Receptors, Virus/metabolism ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Targeting Multiple Binding Sites on Cholera Toxin B with Glycomimetic Polymers Promotes the Formation of Protein-Polymer Aggregates.
Autorzy :
Youn G; Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-6500, United States.
Cervin J; Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, 405 30 Gothenburg, Sweden.
Yu X; Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-6500, United States.
Bhatia SR; Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-6500, United States.
Yrlid U; Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, 405 30 Gothenburg, Sweden.
Sampson NS; Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-6500, United States.
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Źródło :
Biomacromolecules [Biomacromolecules] 2020 Dec 14; Vol. 21 (12), pp. 4878-4887. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article
MeSH Terms :
Cholera Toxin*
Polymers*
Protein Binding*
Animals ; Binding Sites ; G(M1) Ganglioside ; Humans ; Mice
Czasopismo naukowe
Tytuł :
A lattice model on the rate of in vivo site-specific DNA-protein interactions.
Autorzy :
Murugan R; Department of Biotechnology, Indian Institute of Technology Madras, Chennai, India.
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Źródło :
Physical biology [Phys Biol] 2020 Dec 01; Vol. 18 (1), pp. 016005. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Molecular*
Protein Binding*
DNA/*chemistry
Czasopismo naukowe
Tytuł :
Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion.
Autorzy :
Benton DJ; Strutural Biology of Disease Processes Laboratory, Francis Crick Institute, London, UK. .
Wrobel AG; Strutural Biology of Disease Processes Laboratory, Francis Crick Institute, London, UK. .
Xu P; Precision Medicine Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.; Francis Crick Institute, London, UK.
Roustan C; Structural Biology Science Technology Platform, Francis Crick Institute, London, UK.
Martin SR; Strutural Biology of Disease Processes Laboratory, Francis Crick Institute, London, UK.
Rosenthal PB; Structural Biology of Cells and Viruses Laboratory, Francis Crick Institute, London, UK.
Skehel JJ; Strutural Biology of Disease Processes Laboratory, Francis Crick Institute, London, UK.
Gamblin SJ; Strutural Biology of Disease Processes Laboratory, Francis Crick Institute, London, UK. .
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Źródło :
Nature [Nature] 2020 Dec; Vol. 588 (7837), pp. 327-330. Date of Electronic Publication: 2020 Sep 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Binding*
Angiotensin-Converting Enzyme 2/*chemistry
Angiotensin-Converting Enzyme 2/*metabolism
Membrane Fusion/*physiology
Receptors, Coronavirus/*metabolism
Spike Glycoprotein, Coronavirus/*chemistry
Spike Glycoprotein, Coronavirus/*metabolism
Angiotensin-Converting Enzyme 2/ultrastructure ; Cryoelectron Microscopy ; Furin/metabolism ; Humans ; Models, Molecular ; Protein Folding ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Proteolysis ; Receptors, Coronavirus/chemistry ; Receptors, Coronavirus/ultrastructure ; Spike Glycoprotein, Coronavirus/ultrastructure
Czasopismo naukowe
Tytuł :
Peptide Binding to HLA-E Molecules in Humans, Nonhuman Primates, and Mice Reveals Unique Binding Peptides but Remarkably Conserved Anchor Residues.
Autorzy :
Ruibal P; Department of Infectious Diseases, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands; and.
Franken KLMC; Department of Infectious Diseases, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands; and.
van Meijgaarden KE; Department of Infectious Diseases, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands; and.
van Loon JJF; Department of Infectious Diseases, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands; and.
van der Steen D; Department of Hematology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Heemskerk MHM; Department of Hematology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Ottenhoff THM; Department of Infectious Diseases, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands; and .
Joosten SA; Department of Infectious Diseases, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands; and.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2020 Nov 15; Vol. 205 (10), pp. 2861-2872. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Histocompatibility Antigens Class I/*metabolism
Protein Binding/*genetics
T-Lymphocytes/*immunology
Alleles ; Amino Acid Sequence/genetics ; Animals ; Antigens/immunology ; Antigens/metabolism ; Conserved Sequence/genetics ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/immunology ; Humans ; Macaca fascicularis ; Mice ; Peptides/immunology ; Peptides/metabolism ; Protein Binding/immunology ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sequence Homology, Amino Acid ; Species Specificity ; T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł :
AK-Score: Accurate Protein-Ligand Binding Affinity Prediction Using an Ensemble of 3D-Convolutional Neural Networks.
Autorzy :
Kwon Y; Department of Chemistry, Kangwon National University, Gangwon-do, Chuncheon 24341, Korea.
Shin WH; Department of Chemical Science Education, Sunchon National University, Jeollanam-do, Suncheon 57922, Korea.
Ko J; Arontier, 241 Gangnam-daero, Seocho-gu, Seoul 06735, Korea.
Lee J; Department of Chemistry, Kangwon National University, Gangwon-do, Chuncheon 24341, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 10; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article
MeSH Terms :
Neural Networks, Computer*
Protein Binding*
Proteins/*chemistry
Proteins/*metabolism
Computer-Aided Design ; Databases, Protein ; Deep Learning ; Drug Design ; Drug Discovery ; Humans ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; User-Computer Interface
Czasopismo naukowe
Tytuł :
Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.
Autorzy :
Zhu Y; Unité Récepteurs-Canaux, Institut Pasteur, 75015 Paris, France; Complexité du Vivant, Sorbonne Université, 75005 Paris, France.
Delhommel F; Unité Récepteurs-Canaux, Institut Pasteur, 75015 Paris, France; Complexité du Vivant, Sorbonne Université, 75005 Paris, France.
Cordier F; Unité de Bioinformatique Structurale, 75015 Paris, France.
Lüchow S; Department of Chemistry-BMC, Uppsala University, Sweden.
Mechaly A; Plateforme de Cristallographie, Institut Pasteur, Paris, France.
Colcombet-Cazenave B; Unité Récepteurs-Canaux, Institut Pasteur, 75015 Paris, France; Complexité du Vivant, Sorbonne Université, 75005 Paris, France.
Girault V; Unité Récepteurs-Canaux, Institut Pasteur, 75015 Paris, France.
Pepermans E; Complexité du Vivant, Sorbonne Université, 75005 Paris, France; Unité de génétique et physiologie de l'audition, Institut Pasteur, 75015 Paris, France.
Bahloul A; Unité de génétique et physiologie de l'audition, Institut Pasteur, 75015 Paris, France.
Gautier C; Istituto Pasteur - Fondazione C. Bolognetti, Sapienza Università di Roma, Rome, Italy.
Brûlé S; Plateforme de Biophysique Moléculaire, Institut Pasteur, Paris, France.
Raynal B; Plateforme de Biophysique Moléculaire, Institut Pasteur, Paris, France.
Hoos S; Plateforme de Biophysique Moléculaire, Institut Pasteur, Paris, France.
Haouz A; Plateforme de Cristallographie, Institut Pasteur, Paris, France.
Caillet-Saguy C; Unité Récepteurs-Canaux, Institut Pasteur, 75015 Paris, France.
Ivarsson Y; Department of Chemistry-BMC, Uppsala University, Sweden.
Wolff N; Unité Récepteurs-Canaux, Institut Pasteur, 75015 Paris, France. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2020 Nov 06; Vol. 432 (22), pp. 5920-5937. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Binding*
Hair Cells, Auditory/*cytology
Hair Cells, Auditory/*metabolism
Membrane Proteins/*chemistry
Membrane Proteins/*metabolism
PDZ Domains/*physiology
Cell Cycle Proteins/metabolism ; Cytoskeletal Proteins/metabolism ; Guanylate Kinases/metabolism ; Humans ; Myosins/metabolism ; Proteins ; Stereocilia/metabolism
Czasopismo naukowe
Tytuł :
Pharmacokinetics, tissue distribution and plasma protein binding rate of palmatine following intragastric and intravenous administration in rats using liquid chromatography tandem mass spectrometry.
Autorzy :
Song Y; Department of Pharmaceutical Analysis, School of Pharmacy, China Medical University, Puhe Road No. 77, Shenyang City, 110122, Liaoning Province, China.
Wang K; Department of Pharmaceutical Analysis, School of Pharmacy, China Medical University, Puhe Road No. 77, Shenyang City, 110122, Liaoning Province, China.
Wei X; Department of Pharmaceutical Analysis, School of Pharmacy, China Medical University, Puhe Road No. 77, Shenyang City, 110122, Liaoning Province, China.
Wei T; Department of Pharmaceutical Analysis, School of Pharmacy, China Medical University, Puhe Road No. 77, Shenyang City, 110122, Liaoning Province, China.
Xiao T; Department of Pharmaceutical Analysis, School of Pharmacy, China Medical University, Puhe Road No. 77, Shenyang City, 110122, Liaoning Province, China.
Wei M; Department of Pharmacology, School of Pharmacy, China Medical University, Puhe Road No. 77, Shenyang City, 110122, Liaoning Province, China. Electronic address: .
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Źródło :
Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2021 Sep 05; Vol. 203, pp. 114226. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article
MeSH Terms :
Tandem Mass Spectrometry*
Administration, Intravenous ; Animals ; Berberine Alkaloids ; Chromatography, High Pressure Liquid ; Chromatography, Liquid ; Protein Binding ; Rats ; Reproducibility of Results ; Tissue Distribution
Czasopismo naukowe

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