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Tytuł :
The SARS-CoV-2 Nucleocapsid Protein and Its Role in Viral Structure, Biological Functions, and a Potential Target for Drug or Vaccine Mitigation.
Autorzy :
Bai Z; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.; Savaid Medical School, University of the Chinese Academy of Sciences, Beijing 100049, China.
Cao Y; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.; CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
Liu W; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.; Savaid Medical School, University of the Chinese Academy of Sciences, Beijing 100049, China.; Center for Biosafety Mega-Science, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Li J; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.; Savaid Medical School, University of the Chinese Academy of Sciences, Beijing 100049, China.
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Źródło :
Viruses [Viruses] 2021 Jun 10; Vol. 13 (6). Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
COVID-19 Vaccines/*immunology
Coronavirus Nucleocapsid Proteins/*metabolism
SARS-CoV-2/*chemistry
SARS-CoV-2/*metabolism
Animals ; Antiviral Agents/pharmacology ; COVID-19/prevention & control ; Coronavirus Nucleocapsid Proteins/immunology ; Humans ; Mice ; Pharmaceutical Preparations ; SARS-CoV-2/drug effects ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/immunology
Czasopismo naukowe
Tytuł :
Replication Kinetics of B.1.351 and B.1.1.7 SARS-CoV-2 Variants of Concern Including Assessment of a B.1.1.7 Mutant Carrying a Defective ORF7a Gene.
Autorzy :
Pyke AT; Public Health Virology Laboratory, Forensic and Scientific Services, Department of Health, Queensland Government, Coopers Plains, QLD 4108, Australia.
Nair N; Public Health Virology Laboratory, Forensic and Scientific Services, Department of Health, Queensland Government, Coopers Plains, QLD 4108, Australia.
van den Hurk AF; Public Health Virology Laboratory, Forensic and Scientific Services, Department of Health, Queensland Government, Coopers Plains, QLD 4108, Australia.
Burtonclay P; Public Health Virology Laboratory, Forensic and Scientific Services, Department of Health, Queensland Government, Coopers Plains, QLD 4108, Australia.
Nguyen S; Public Health Microbiology Laboratory, Forensic and Scientific Services, Department of Health, Queensland Government, Coopers Plains, QLD 4108, Australia.
Barcelon J; Public Health Virology Laboratory, Forensic and Scientific Services, Department of Health, Queensland Government, Coopers Plains, QLD 4108, Australia.
Kistler C; Public Health Virology Laboratory, Forensic and Scientific Services, Department of Health, Queensland Government, Coopers Plains, QLD 4108, Australia.
Schlebusch S; Public and Environmental Health, Forensic and Scientific Services, Department of Health, Queensland Government, Coopers Plains, QLD 4108, Australia.; Pathology Queensland, Royal Brisbane and Women's Hospital, Herston, QLD 4006, Australia.; School of Medicine, Faculty of Medicine, University of Queensland, Herston, QLD 4072, Australia.
McMahon J; Public Health Virology Laboratory, Forensic and Scientific Services, Department of Health, Queensland Government, Coopers Plains, QLD 4108, Australia.
Moore F; Public Health Virology Laboratory, Forensic and Scientific Services, Department of Health, Queensland Government, Coopers Plains, QLD 4108, Australia.
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Źródło :
Viruses [Viruses] 2021 Jun 07; Vol. 13 (6). Date of Electronic Publication: 2021 Jun 07.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Virus Replication*
Open Reading Frames/*genetics
SARS-CoV-2/*genetics
SARS-CoV-2/*physiology
Viral Proteins/*genetics
Adult ; Animals ; Australia ; COVID-19/prevention & control ; COVID-19/transmission ; COVID-19/virology ; Chlorocebus aethiops ; High-Throughput Nucleotide Sequencing ; Humans ; Kinetics ; Middle Aged ; Mutation ; Nasopharynx/virology ; Phylogeny ; SARS-CoV-2/classification ; South Africa ; United Kingdom ; Vero Cells
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
SARS-CoV-2: Insight in genome structure, pathogenesis and viral receptor binding analysis - An updated review.
Autorzy :
Bhat EA; Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, PR China.
Khan J; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah 11952, Saudi Arabia. Electronic address: .
Sajjad N; Department of Biochemistry, University of Kashmir, Hazratbal, Jammu and Kashmir, India.
Ali A; Department of Life Sciences, University of Mumbai, Vidyanagari, Santacruz (E), Mumbai 400098, India.
Aldakeel FM; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
Mateen A; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
Alqahtani MS; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Syed R; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
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Źródło :
International immunopharmacology [Int Immunopharmacol] 2021 Jun; Vol. 95, pp. 107493. Date of Electronic Publication: 2021 Feb 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
COVID-19/*etiology
SARS-CoV-2/*genetics
SARS-CoV-2/*pathogenicity
Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; Animals ; COVID-19/diagnosis ; COVID-19/drug therapy ; COVID-19/transmission ; COVID-19 Vaccines/therapeutic use ; Chloroquine/therapeutic use ; Genome, Viral ; Humans ; Receptors, Coronavirus/chemistry ; Receptors, Coronavirus/genetics ; SARS-CoV-2/chemistry ; SARS-CoV-2/drug effects ; Virus Attachment
Czasopismo naukowe
Tytuł :
India's COVID crisis flags need to forecast variants.
Autorzy :
Agrawal A
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Źródło :
Nature [Nature] 2021 Jun; Vol. 594 (7861), pp. 9.
Typ publikacji :
Wiadomości
MeSH Terms :
Epidemiological Monitoring*
Forecasting*
COVID-19/*prevention & control
COVID-19/*virology
SARS-CoV-2/*genetics
SARS-CoV-2/*isolation & purification
COVID-19/diagnosis ; COVID-19/transmission ; COVID-19 Vaccines/immunology ; Genome, Viral/genetics ; Genomics ; High-Throughput Nucleotide Sequencing ; Humans ; India/epidemiology ; Mutation ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Time Factors
SCR Organism :
SARS-CoV-2 variants
Periodyk
Tytuł :
Human Immunodeficiency Viruses Pseudotyped with SARS-CoV-2 Spike Proteins Infect a Broad Spectrum of Human Cell Lines through Multiple Entry Mechanisms.
Autorzy :
Xu C; Public Health Research Institute, Rutgers, the State University of New Jersey, Newark, NJ 07103, USA.
Wang A; Public Health Research Institute, Rutgers, the State University of New Jersey, Newark, NJ 07103, USA.
Geng K; Public Health Research Institute, Rutgers, the State University of New Jersey, Newark, NJ 07103, USA.
Honnen W; Public Health Research Institute, Rutgers, the State University of New Jersey, Newark, NJ 07103, USA.
Wang X; Laboratory Medicine, Rutgers, Department of Pathology, Immunology, the State University of New Jersey, Newark, NJ 07103, USA.
Bruiners N; Public Health Research Institute, Rutgers, the State University of New Jersey, Newark, NJ 07103, USA.
Singh S; NJMS Flow Cytometry and Immunology Core Laboratory, New Jersey Medical School, Rutgers, the State University of New Jersey, Newark, NJ 07103, USA.
Ferrara F; Specifica Inc., Santa Fe, NM 87505, USA.
D'Angelo S; Specifica Inc., Santa Fe, NM 87505, USA.
Bradbury ARM; Specifica Inc., Santa Fe, NM 87505, USA.
Gennaro ML; Public Health Research Institute, Rutgers, the State University of New Jersey, Newark, NJ 07103, USA.
Liu D; Laboratory Medicine, Rutgers, Department of Pathology, Immunology, the State University of New Jersey, Newark, NJ 07103, USA.
Pinter A; Public Health Research Institute, Rutgers, the State University of New Jersey, Newark, NJ 07103, USA.
Chang TL; Public Health Research Institute, Rutgers, the State University of New Jersey, Newark, NJ 07103, USA.; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers, the State University of New Jersey, Newark, NJ 07103, USA.
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Źródło :
Viruses [Viruses] 2021 May 21; Vol. 13 (6). Date of Electronic Publication: 2021 May 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Virus Internalization*
HIV/*genetics
SARS-CoV-2/*physiology
Spike Glycoprotein, Coronavirus/*physiology
Caco-2 Cells ; Cell Line ; Genetic Vectors ; HEK293 Cells ; Humans ; Plasmids ; SARS-CoV-2/genetics ; SARS-CoV-2/pathogenicity ; Spike Glycoprotein, Coronavirus/genetics ; Transfection ; vpr Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
Tytuł :
SARS-CoV-2: Insights into its structural intricacies and functional aspects for drug and vaccine development.
Autorzy :
Kaur M; Department of Biophysics, Panjab University, Chandigarh 160014, India.
Sharma A; Department of Biophysics, Panjab University, Chandigarh 160014, India; UIPS, Panjab University, Chandigarh 160014, India.
Kumar S; Department of Biotechnology, Panjab University, Chandigarh 160014, India.
Singh G; UIPS, Panjab University, Chandigarh 160014, India.
Barnwal RP; Department of Biophysics, Panjab University, Chandigarh 160014, India. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 May 15; Vol. 179, pp. 45-60. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
COVID-19/*therapy
COVID-19/*virology
SARS-CoV-2/*chemistry
SARS-CoV-2/*ultrastructure
COVID-19/epidemiology ; COVID-19/transmission ; Humans ; SARS-CoV-2/drug effects ; SARS-CoV-2/genetics
Czasopismo naukowe
Tytuł :
Coronavirus variants are spreading in India - what scientists know so far.
Autorzy :
Vaidyanathan G
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Źródło :
Nature [Nature] 2021 May; Vol. 593 (7859), pp. 321-322.
Typ publikacji :
Wiadomości
MeSH Terms :
COVID-19/*transmission
COVID-19/*virology
COVID-19 Vaccines/*immunology
SARS-CoV-2/*genetics
SARS-CoV-2/*pathogenicity
Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Brazil/epidemiology ; COVID-19/epidemiology ; COVID-19/immunology ; Cells, Cultured ; Cricetinae ; Genetic Fitness ; Humans ; Immune Evasion/immunology ; India/epidemiology ; Prevalence ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; South Africa/epidemiology ; T-Lymphocytes/immunology ; United Kingdom/epidemiology
SCR Organism :
SARS-CoV-2 variants
Periodyk
Tytuł :
Similarities and differences in the conformational stability and reversibility of ORF8, an accessory protein of SARS-CoV-2, and its L84S variant.
Autorzy :
Ohki S; Center for Nano Materials and Technology (CNMT), Japan Advanced Institute of Science and Technology (JAIST), 1-1 Asahidai, Nomi, Ishikawa, 923-1292, Japan. Electronic address: .
Imamura T; Department of Bioproduction Science, Ishikawa Prefectural University, 308-1 Suematsu, Nonoichi, Ishikawa, 921-8836, Japan.
Higashimura Y; Department of Food Science, Ishikawa Prefectural University, 308-1 Suematsu, Nonoichi, Ishikawa, 921-8836, Japan.
Matsumoto K; Department of Food Science, Ishikawa Prefectural University, 308-1 Suematsu, Nonoichi, Ishikawa, 921-8836, Japan.
Mori M; Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University, 308-1 Suematsu, Nonoichi, Ishikawa, 921-8836, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jul 23; Vol. 563, pp. 92-97. Date of Electronic Publication: 2021 May 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*virology
SARS-CoV-2/*chemistry
Viral Proteins/*chemistry
COVID-19/metabolism ; COVID-19/pathology ; Humans ; Molecular Conformation ; Mutation ; Nuclear Magnetic Resonance, Biomolecular/methods ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/metabolism ; Structure-Activity Relationship ; Viral Proteins/genetics ; Viral Proteins/metabolism
Czasopismo naukowe
Tytuł :
Structural Modeling of the SARS-CoV-2 Spike/Human ACE2 Complex Interface can Identify High-Affinity Variants Associated with Increased Transmissibility.
Autorzy :
Gan HH; Center for Genomics and Systems Biology, Department of Biology, New York University, 12 Waverly Place, New York, NY 10003, United States. Electronic address: .
Twaddle A; Center for Genomics and Systems Biology, Department of Biology, New York University, 12 Waverly Place, New York, NY 10003, United States; NYU Abu Dhabi Center for Genomics and Systems Biology, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates.
Marchand B; High-Performance Computing, Center for Research Computing, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates.
Gunsalus KC; Center for Genomics and Systems Biology, Department of Biology, New York University, 12 Waverly Place, New York, NY 10003, United States; NYU Abu Dhabi Center for Genomics and Systems Biology, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Jul 23; Vol. 433 (15), pp. 167051. Date of Electronic Publication: 2021 May 14.
Typ publikacji :
Journal Article
MeSH Terms :
Mutation*
Angiotensin-Converting Enzyme 2/*chemistry
Angiotensin-Converting Enzyme 2/*metabolism
COVID-19/*transmission
SARS-CoV-2/*pathogenicity
Spike Glycoprotein, Coronavirus/*chemistry
Spike Glycoprotein, Coronavirus/*metabolism
Angiotensin-Converting Enzyme 2/genetics ; Binding Sites ; Computational Biology ; Humans ; Models, Molecular ; Protein Binding ; Protein Conformation ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/genetics ; Virus Internalization
Czasopismo naukowe
Tytuł :
Mutation-Specific SARS-CoV-2 PCR Screen: Rapid and Accurate Detection of Variants of Concern and the Identification of a Newly Emerging Variant with Spike L452R Mutation.
Autorzy :
Wang H; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.; Department of Pathology, The Ohio State University, Columbus, Ohio, USA.
Jean S; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.; Department of Pathology, The Ohio State University, Columbus, Ohio, USA.
Eltringham R; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.
Madison J; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.
Snyder P; Department of Pathology, The Ohio State University, Columbus, Ohio, USA.
Tu H; Department of Pathology, The Ohio State University, Columbus, Ohio, USA.
Jones DM; Department of Pathology, The Ohio State University, Columbus, Ohio, USA.
Leber AL; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.; Department of Pathology, The Ohio State University, Columbus, Ohio, USA.; Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA.
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Źródło :
Journal of clinical microbiology [J Clin Microbiol] 2021 Jul 19; Vol. 59 (8), pp. e0092621. Date of Electronic Publication: 2021 Jul 19.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19*
SARS-CoV-2*
Humans ; Multiplex Polymerase Chain Reaction ; Mutation ; Spike Glycoprotein, Coronavirus/genetics
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
Pathogenic perspective of missense mutations of ORF3a protein of SARS-CoV-2.
Autorzy :
Hassan SS; Department of Mathematics, Pingla Thana Mahavidyalaya, Maligram 721140, India. Electronic address: .
Attrish D; Dr. B. R. Ambedkar Centre For Biomedical Research (ACBR), University of Delhi (North Campus), Delhi 110007, India. Electronic address: .
Ghosh S; Department of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, Kolkata 700009, West Bengal, India. Electronic address: .
Choudhury PP; Applied Statistics Unit, Indian Statistical Institute, Kolkata 700108, West Bengal, India. Electronic address: .
Roy B; Human Genetics Unit, Indian Statistical Institute, Kolkata 700108, West Bengal, India. Electronic address: .
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Źródło :
Virus research [Virus Res] 2021 Jul 15; Vol. 300, pp. 198441. Date of Electronic Publication: 2021 Apr 30.
Typ publikacji :
Journal Article
MeSH Terms :
SARS-CoV-2*/genetics
SARS-CoV-2*/pathogenicity
Viroporin Proteins*/chemistry
Viroporin Proteins*/genetics
Virulence Factors*/chemistry
Virulence Factors*/genetics
COVID-19/*virology
Databases, Genetic ; Genes, Viral ; Genetic Variation ; Humans ; Mutation, Missense ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Epitope mapping of severe acute respiratory syndrome-related coronavirus nucleocapsid protein with a rabbit monoclonal antibody.
Autorzy :
Tian X; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 510182, China. Electronic address: .
Mo C; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 510182, China.
Zhou L; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 510182, China.
Yang Y; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 510182, China.
Zhou Z; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 510182, China.
You A; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 510182, China.
Fan Y; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 510182, China.
Liu W; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 510182, China.
Li X; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 510182, China.
Zhou R; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 510182, China. Electronic address: .
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Źródło :
Virus research [Virus Res] 2021 Jul 15; Vol. 300, pp. 198445. Date of Electronic Publication: 2021 May 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
SARS-CoV-2*/immunology
SARS-CoV-2*/isolation & purification
Antibodies, Monoclonal/*immunology
COVID-19/*diagnosis
COVID-19 Serological Testing/*methods
Coronavirus Nucleocapsid Proteins/*immunology
Epitope Mapping ; Humans ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
Evaluation of kinetics and thermodynamics of interaction between immobilized SARS-CoV-2 nucleoprotein and specific antibodies by total internal reflection ellipsometry.
Autorzy :
Plikusiene I; NanoTechnas - Center of Nanotechnology and Materials Science, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko str. 24, 03225 Vilnius, Lithuania; State Research Institute Center for Physical and Technological Sciences, Sauletekio ave. 3, Vilnius, Lithuania.
Maciulis V; NanoTechnas - Center of Nanotechnology and Materials Science, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko str. 24, 03225 Vilnius, Lithuania; State Research Institute Center for Physical and Technological Sciences, Sauletekio ave. 3, Vilnius, Lithuania.
Ramanaviciene A; NanoTechnas - Center of Nanotechnology and Materials Science, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko str. 24, 03225 Vilnius, Lithuania.
Balevicius Z; State Research Institute Center for Physical and Technological Sciences, Sauletekio ave. 3, Vilnius, Lithuania.
Buzavaite-Verteliene E; State Research Institute Center for Physical and Technological Sciences, Sauletekio ave. 3, Vilnius, Lithuania.
Ciplys E; Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio ave. 7, LT-10257 Vilnius, Lithuania.
Slibinskas R; Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio ave. 7, LT-10257 Vilnius, Lithuania.
Simanavicius M; Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio ave. 7, LT-10257 Vilnius, Lithuania.
Zvirbliene A; Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio ave. 7, LT-10257 Vilnius, Lithuania.
Ramanavicius A; NanoTechnas - Center of Nanotechnology and Materials Science, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko str. 24, 03225 Vilnius, Lithuania; State Research Institute Center for Physical and Technological Sciences, Sauletekio ave. 3, Vilnius, Lithuania.
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Źródło :
Journal of colloid and interface science [J Colloid Interface Sci] 2021 Jul 15; Vol. 594, pp. 195-203. Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
SARS-CoV-2*
Antibodies, Viral/*chemistry
Nucleoproteins/*chemistry
Kinetics ; Thermodynamics
Czasopismo naukowe
Tytuł :
Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species.
Autorzy :
Wang R; NexVac Research Center, Comprehensive AIDS Research Center, Center for Infectious Disease Research, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Joint Center for Life Sciences, Beijing 100084, China.
Zhang Q; NexVac Research Center, Comprehensive AIDS Research Center, Center for Infectious Disease Research, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, Beijing 100084, China.
Ge J; The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Ren W; Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing 100084, China; Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing 100084, China.
Zhang R; NexVac Research Center, Comprehensive AIDS Research Center, Center for Infectious Disease Research, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, Beijing 100084, China.
Lan J; The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Ju B; Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen 518112, Guangdong Province, China; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Su B; Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Yu F; Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, No. 8, Jing Shun Dong Jie, Chaoyang, 100015 District Beijing, China.
Chen P; NexVac Research Center, Comprehensive AIDS Research Center, Center for Infectious Disease Research, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, Beijing 100084, China.
Liao H; Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Feng Y; Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Li X; Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Shi X; NexVac Research Center, Comprehensive AIDS Research Center, Center for Infectious Disease Research, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, Beijing 100084, China.
Zhang Z; Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen 518112, Guangdong Province, China; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Zhang F; Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, No. 8, Jing Shun Dong Jie, Chaoyang, 100015 District Beijing, China.
Ding Q; Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing 100084, China; Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing 100084, China.
Zhang T; Beijing Youan Hospital, Capital Medical University, Beijing 100069, China. Electronic address: .
Wang X; The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address: .
Zhang L; NexVac Research Center, Comprehensive AIDS Research Center, Center for Infectious Disease Research, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, Beijing 100084, China; Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China; Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen 518132, China. Electronic address: .
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Źródło :
Immunity [Immunity] 2021 Jul 13; Vol. 54 (7), pp. 1611-1621.e5. Date of Electronic Publication: 2021 Jun 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immune Evasion*/genetics
Angiotensin-Converting Enzyme 2/*metabolism
Antibodies, Neutralizing/*immunology
SARS-CoV-2/*immunology
Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/immunology ; Antibodies, Neutralizing/chemistry ; Antigenic Variation/genetics ; COVID-19/immunology ; COVID-19/virology ; Host Specificity ; Humans ; Mice ; Mink ; Mutation ; Protein Binding ; SARS-CoV-2/genetics ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Internalization
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing Responses.
Autorzy :
Carnell GW; Laboratory of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Ciazynska KA; Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
Wells DA; DIOSynVax, University of Cambridge, Cambridge, United Kingdom.
Xiong X; Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
Aguinam ET; Laboratory of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
McLaughlin SH; Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
Mallery D; Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
Ebrahimi S; Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, United Kingdom.
Ceron-Gutierrez L; Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, United Kingdom.
Asbach B; Institute of Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany.
Einhauser S; Institute of Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany.
Wagner R; Institute of Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany.; Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Regensburg, Germany.
James LC; Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
Doffinger R; Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, United Kingdom.
Heeney JL; Laboratory of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.; DIOSynVax, University of Cambridge, Cambridge, United Kingdom.
Briggs JAG; Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
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Źródło :
Journal of virology [J Virol] 2021 Jul 12; Vol. 95 (15), pp. e0020321. Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin-Converting Enzyme 2*/chemistry
Angiotensin-Converting Enzyme 2*/immunology
Antibodies, Neutralizing*/chemistry
Antibodies, Neutralizing*/immunology
Antibodies, Viral*/chemistry
Antibodies, Viral*/immunology
Epitopes*/chemistry
Epitopes*/immunology
SARS-CoV-2*/chemistry
SARS-CoV-2*/immunology
Spike Glycoprotein, Coronavirus*/chemistry
Spike Glycoprotein, Coronavirus*/immunology
Animals ; COVID-19 Vaccines/chemistry ; COVID-19 Vaccines/immunology ; HEK293 Cells ; Humans ; Mice ; Protein Stability
Czasopismo naukowe
Tytuł :
Recognition through GRP78 is enhanced in the UK, South African, and Brazilian variants of SARS-CoV-2; An in silico perspective.
Autorzy :
Ibrahim IM; Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt.
Elfiky AA; Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt. Electronic address: .
Elgohary AM; Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt.
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jul 12; Vol. 562, pp. 89-93. Date of Electronic Publication: 2021 May 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Computer Simulation*
Heat-Shock Proteins/*metabolism
SARS-CoV-2/*metabolism
Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/metabolism ; Brazil ; Heat-Shock Proteins/chemistry ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Mutation ; Receptors, Virus/chemistry ; Receptors, Virus/metabolism ; SARS-CoV-2/chemistry ; SARS-CoV-2/genetics ; South Africa ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Substrate Specificity ; United Kingdom ; Virus Internalization
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
Limited Diagnostic Utility of SARS-CoV-2 Serologic Testing in Symptomatic PCR Negative Patients.
Autorzy :
Tawiah KD; Department of Pathology and Immunology, Washington University in St. Louis, MO.
Hock KG; Department of Pathology and Immunology, Washington University in St. Louis, MO.
Farnsworth CW; Department of Pathology and Immunology, Washington University in St. Louis, MO.
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Źródło :
The journal of applied laboratory medicine [J Appl Lab Med] 2021 Jul 07; Vol. 6 (4), pp. 1083-1085.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Viral/*blood
COVID-19/*diagnosis
COVID-19 Testing/*methods
Polymerase Chain Reaction/*methods
SARS-CoV-2/*isolation & purification
Antibodies, Viral/immunology ; COVID-19/blood ; COVID-19/genetics ; COVID-19/virology ; Humans ; Predictive Value of Tests ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology
Czasopismo naukowe
Tytuł :
Longitudinal Assessment of SARS-CoV-2 Antinucleocapsid and Antispike-1-RBD Antibody Testing Following PCR-Detected SARS-CoV-2 Infection.
Autorzy :
El-Khoury JM; Department of Laboratory Medicine, Yale University, New Haven, CT.
Schulz WL; Department of Laboratory Medicine, Yale University, New Haven, CT.
Durant TJS; Department of Laboratory Medicine, Yale University, New Haven, CT.
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Źródło :
The journal of applied laboratory medicine [J Appl Lab Med] 2021 Jul 07; Vol. 6 (4), pp. 1005-1011.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Viral/*blood
COVID-19/*diagnosis
COVID-19 Testing/*methods
Nucleocapsid/*immunology
Polymerase Chain Reaction/*methods
SARS-CoV-2/*isolation & purification
Spike Glycoprotein, Coronavirus/*immunology
Antibodies, Viral/immunology ; COVID-19/blood ; COVID-19/genetics ; COVID-19/virology ; Europe ; Humans ; Longitudinal Studies ; Predictive Value of Tests ; Reagent Kits, Diagnostic ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; United States
Czasopismo naukowe
Tytuł :
Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants.
Autorzy :
Wagner JUG; Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Frankfurt, Germany.; Cardiopulmonary Institute (CPI), Frankfurt, Germany.
Bojkova D; Institute of Medical Virology, University Frankfurt, Frankfurt, Germany.
Shumliakivska M; Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt, Germany.
Luxán G; Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Frankfurt, Germany.; Cardiopulmonary Institute (CPI), Frankfurt, Germany.
Nicin L; Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt, Germany.
Aslan GS; Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt, Germany.
Milting H; Clinic for Thoracic and Cardiovascular Surgery, Bad Oeyenhausen, Germany.
Kandler JD; Institute of Medical Virology, University Frankfurt, Frankfurt, Germany.
Dendorfer A; German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Frankfurt, Germany.; Walter-Brendel-Centre, Hospital of the Ludwig-Maximilians-University München, Munich, Germany.
Heumueller AW; Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt, Germany.; Cardiopulmonary Institute (CPI), Frankfurt, Germany.
Fleming I; German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Frankfurt, Germany.; Cardiopulmonary Institute (CPI), Frankfurt, Germany.; Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany.
Bibli SI; German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Frankfurt, Germany.; Cardiopulmonary Institute (CPI), Frankfurt, Germany.; Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany.
Jakobi T; Department of Internal Medicine and the Center for Translational Cardiovascular Research, University of Arizona, 475 N. 5th Street, Phoenix, AZ, 85004, USA.
Dieterich C; German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Frankfurt, Germany.; Klaus Tschira Institute for Integrative Computational Cardiology, University Hospital Heidelberg, Heidelberg, Germany.
Zeiher AM; German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Frankfurt, Germany.; Cardiopulmonary Institute (CPI), Frankfurt, Germany.; Department of Cardiology, University Frankfurt, Frankfurt, Germany.
Ciesek S; Institute of Medical Virology, University Frankfurt, Frankfurt, Germany.; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch Translational Medicine und Pharmacology, Frankfurt, Germany.; German Centre for Infection Research (DZIF), External Partner Site Frankfurt, Frankfurt, Germany.
Cinatl J; Institute of Medical Virology, University Frankfurt, Frankfurt, Germany.
Dimmeler S; Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt, Germany. .; German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Frankfurt, Germany. .; Cardiopulmonary Institute (CPI), Frankfurt, Germany. .
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Źródło :
Basic research in cardiology [Basic Res Cardiol] 2021 Jul 05; Vol. 116 (1), pp. 42. Date of Electronic Publication: 2021 Jul 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endoplasmic Reticulum/*virology
Endothelial Cells/*virology
SARS-CoV-2/*pathogenicity
Angiotensin-Converting Enzyme 2/metabolism ; Calnexin/metabolism ; Cells, Cultured ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress ; Endothelial Cells/metabolism ; Host-Pathogen Interactions ; Humans ; Membrane Proteins/metabolism ; Receptors, Virus/metabolism ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/metabolism
Czasopismo naukowe
Tytuł :
SARS-CoV-2 presented moderately during two episodes of the infection with lack of antibody responses.
Autorzy :
Salehi-Vaziri M; COVID-19 National Reference Laboratory, Pasteur Institute of Iran, Tehran, Iran; Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran.
Omrani MD; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Pouriayevali MH; COVID-19 National Reference Laboratory, Pasteur Institute of Iran, Tehran, Iran; Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran.
Fotouhi F; Department of Influenza and Other Respiratory Viruses of Pasteur Institute of Iran, Tehran, Iran.
Banifazl M; Iranian Society for Support of Patients with Infectious Disease, Tehran, Iran.
Farahmand B; Department of Influenza and Other Respiratory Viruses of Pasteur Institute of Iran, Tehran, Iran.
Sadat Larijani M; Clinical Research Department, Pasteur Institute of Iran, Tehran, Iran.
Ahmadi Z; COVID-19 National Reference Laboratory, Pasteur Institute of Iran, Tehran, Iran; Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran.
Fereydouni Z; COVID-19 National Reference Laboratory, Pasteur Institute of Iran, Tehran, Iran; Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran.
Tavakoli M; COVID-19 National Reference Laboratory, Pasteur Institute of Iran, Tehran, Iran; Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran.
Jalali T; COVID-19 National Reference Laboratory, Pasteur Institute of Iran, Tehran, Iran; Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran. Electronic address: .
Ramezani A; Clinical Research Department, Pasteur Institute of Iran, Tehran, Iran. Electronic address: .
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Źródło :
Virus research [Virus Res] 2021 Jul 02; Vol. 299, pp. 198421. Date of Electronic Publication: 2021 Apr 06.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*virology
Reinfection/*virology
SARS-CoV-2/*isolation & purification
Adult ; Antibodies, Viral/blood ; COVID-19/diagnosis ; Genome, Viral/genetics ; Humans ; Male ; Mutation ; Phylogeny ; RNA, Viral/genetics ; Reinfection/diagnosis ; SARS-CoV-2/classification ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology
Czasopismo naukowe

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