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Tytuł :
Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood.
Autorzy :
Dutta D; Department of Biostatistics, Johns Hopkins University, Baltimore, MD, USA.
He Y; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Saha A; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA.
Arvanitis M; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.; Department of Cardiology, Johns Hopkins University, Baltimore, MD, USA.
Battle A; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA. .; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA. .
Chatterjee N; Department of Biostatistics, Johns Hopkins University, Baltimore, MD, USA. .; Department of Oncology, Johns Hopkins University, Baltimore, MD, USA. .
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Źródło :
Nature communications [Nat Commun] 2022 Jul 26; Vol. 13 (1), pp. 4323. Date of Electronic Publication: 2022 Jul 26.
Typ publikacji :
Journal Article
MeSH Terms :
Genome-Wide Association Study*/methods
Quantitative Trait Loci*/genetics
Genetic Association Studies ; Multifactorial Inheritance ; Phenotype ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł :
sumSTAAR: A flexible framework for gene-based association studies using GWAS summary statistics.
Autorzy :
Belonogova NM; Laboratory of Segregation and Recombination Analyses, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Svishcheva GR; Laboratory of Segregation and Recombination Analyses, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.; Laboratory of Animal Genetics, Vavilov Institute of General Genetics, the Russian Academy of Sciences, Moscow, Russia.
Kirichenko AV; Laboratory of Segregation and Recombination Analyses, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Zorkoltseva IV; Laboratory of Segregation and Recombination Analyses, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Tsepilov YA; Laboratory of Segregation and Recombination Analyses, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.; Department of Natural Sciences, Novosibirsk State University, Novosibirsk, Russia.
Axenovich TI; Laboratory of Segregation and Recombination Analyses, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2022 Jun 02; Vol. 18 (6), pp. e1010172. Date of Electronic Publication: 2022 Jun 02 (Print Publication: 2022).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome-Wide Association Study*/methods
Quantitative Trait Loci*
Genetic Association Studies ; Phenotype ; Polymorphism, Single Nucleotide/genetics
Czasopismo naukowe
Tytuł :
A computationally efficient clustering linear combination approach to jointly analyze multiple phenotypes for GWAS.
Autorzy :
Wang M; Mathematical Sciences, Michigan Technological University, Houghton, MI, United States of America.
Zhang S; Mathematical Sciences, Michigan Technological University, Houghton, MI, United States of America.
Sha Q; Mathematical Sciences, Michigan Technological University, Houghton, MI, United States of America.
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Źródło :
PloS one [PLoS One] 2022 Apr 28; Vol. 17 (4), pp. e0260911. Date of Electronic Publication: 2022 Apr 28 (Print Publication: 2022).
Typ publikacji :
Journal Article
MeSH Terms :
Genome-Wide Association Study*/methods
Cluster Analysis ; Computer Simulation ; Genetic Association Studies ; Phenotype
Czasopismo naukowe
Tytuł :
Associations of osteoprotegerin (OPG) TNFRSF11B gene polymorphisms with risk of fractures in older adult populations: meta-analysis of genetic and genome-wide association studies.
Autorzy :
Tharabenjasin P; Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, 12120, Thailand.
Pabalan N; Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, 12120, Thailand. .
Jarjanazi H; Environmental Monitoring and Reporting Branch, Ontario Ministry of the Environment, Conservation and Parks, 125 Resources Road, Toronto, ON, Canada.
Jinawath N; Integrative Computational Bioscience Center (ICBS), Mahidol University, Nakhon Pathom, 73170, Thailand.; Program in Translational Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.
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Źródło :
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [Osteoporos Int] 2022 Mar; Vol. 33 (3), pp. 563-575. Date of Electronic Publication: 2021 Oct 30.
Typ publikacji :
Journal Article; Meta-Analysis
MeSH Terms :
Fractures, Bone*
Genome-Wide Association Study*
Aged ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Osteoprotegerin/genetics ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł :
Preparation and Curation of Multiyear, Multilocation, Multitrait Datasets.
Autorzy :
Abed A; Consortium de recherche sur la pomme de terre du Québec (CRPTQ), Québec, Canada. .
Kehel Z; International Center for Agricultural Research in the Dry Areas (ICARDA), Rabat, Morocco. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2481, pp. 83-104.
Typ publikacji :
Journal Article
MeSH Terms :
Genome-Wide Association Study*
Genetic Association Studies ; Linear Models
Czasopismo naukowe
Tytuł :
Discovery of genomic loci of the human cerebral cortex using genetically informed brain atlases.
Autorzy :
Makowski C; Center for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
van der Meer D; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, Netherlands.
Dong W; Department of Bioengineering, University of California, San Diego, CA, USA.
Wang H; Center for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
Wu Y; Department of Bioengineering, University of California, San Diego, CA, USA.
Zou J; Division of Biostatistics, Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, CA, USA.
Liu C; Center for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
Rosenthal SB; Center for Computational Biology and Bioinformatics, University of California, San Diego, CA, USA.
Hagler DJ Jr; Center for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
Fan CC; Center for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
Kremen WS; Department of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, CA, USA.
Andreassen OA; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Jernigan TL; Center for Human Development, University of California, San Diego, CA, USA.
Dale AM; Center for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Zhang K; Department of Bioengineering, University of California, San Diego, CA, USA.
Visscher PM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Yang J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
Chen CH; Center for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2022 Feb 04; Vol. 375 (6580), pp. 522-528. Date of Electronic Publication: 2022 Feb 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Association Studies*
Genetic Loci*
Genetic Variation*
Cerebral Cortex/*anatomy & histology
Cerebral Cortex/*physiology
Adult ; Aged ; Aged, 80 and over ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/growth & development ; Child ; Chromatin/genetics ; Cohort Studies ; Female ; Gene Ontology ; Genome, Human ; Genome-Wide Association Study ; Humans ; Magnetic Resonance Imaging ; Male ; Mental Disorders/genetics ; Middle Aged ; Molecular Sequence Annotation ; Multifactorial Inheritance ; Polymorphism, Single Nucleotide ; Regulatory Sequences, Nucleic Acid
Czasopismo naukowe
Tytuł :
Human Leukocyte Antigen Association Study Reveals DRB1*04:02 Effects Additional to DRB1*07:01 in Anti-LGI1 Encephalitis.
Autorzy :
Peris Sempere V; From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), Stanford University School of Medicine, Palo Alto, CA; French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hôpital Neurologique; Synatac Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM U1217/CNRS UMR5310, Université Claude Bernard Lyon 1, Université de Lyon, France; Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and S.D.), University of California, San Francisco; Department of Neurology (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University of Oxford, United Kingdom.
Muñiz-Castrillo S; From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), Stanford University School of Medicine, Palo Alto, CA; French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hôpital Neurologique; Synatac Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM U1217/CNRS UMR5310, Université Claude Bernard Lyon 1, Université de Lyon, France; Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and S.D.), University of California, San Francisco; Department of Neurology (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University of Oxford, United Kingdom.
Ambati A; From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), Stanford University School of Medicine, Palo Alto, CA; French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hôpital Neurologique; Synatac Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM U1217/CNRS UMR5310, Université Claude Bernard Lyon 1, Université de Lyon, France; Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and S.D.), University of California, San Francisco; Department of Neurology (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University of Oxford, United Kingdom.
Binks S; From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), Stanford University School of Medicine, Palo Alto, CA; French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hôpital Neurologique; Synatac Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM U1217/CNRS UMR5310, Université Claude Bernard Lyon 1, Université de Lyon, France; Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and S.D.), University of California, San Francisco; Department of Neurology (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University of Oxford, United Kingdom.
Pinto AL; From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), Stanford University School of Medicine, Palo Alto, CA; French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hôpital Neurologique; Synatac Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM U1217/CNRS UMR5310, Université Claude Bernard Lyon 1, Université de Lyon, France; Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and S.D.), University of California, San Francisco; Department of Neurology (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University of Oxford, United Kingdom.
Rogemond V; From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), Stanford University School of Medicine, Palo Alto, CA; French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hôpital Neurologique; Synatac Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM U1217/CNRS UMR5310, Université Claude Bernard Lyon 1, Université de Lyon, France; Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and S.D.), University of California, San Francisco; Department of Neurology (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University of Oxford, United Kingdom.
Pittock SJ; From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), Stanford University School of Medicine, Palo Alto, CA; French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hôpital Neurologique; Synatac Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM U1217/CNRS UMR5310, Université Claude Bernard Lyon 1, Université de Lyon, France; Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and S.D.), University of California, San Francisco; Department of Neurology (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University of Oxford, United Kingdom.
Dubey D; From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), Stanford University School of Medicine, Palo Alto, CA; French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hôpital Neurologique; Synatac Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM U1217/CNRS UMR5310, Université Claude Bernard Lyon 1, Université de Lyon, France; Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and S.D.), University of California, San Francisco; Department of Neurology (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University of Oxford, United Kingdom.
Geschwind MD; From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), Stanford University School of Medicine, Palo Alto, CA; French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hôpital Neurologique; Synatac Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM U1217/CNRS UMR5310, Université Claude Bernard Lyon 1, Université de Lyon, France; Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and S.D.), University of California, San Francisco; Department of Neurology (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University of Oxford, United Kingdom.
Gelfand JM; From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), Stanford University School of Medicine, Palo Alto, CA; French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hôpital Neurologique; Synatac Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM U1217/CNRS UMR5310, Université Claude Bernard Lyon 1, Université de Lyon, France; Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and S.D.), University of California, San Francisco; Department of Neurology (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University of Oxford, United Kingdom.
Dilwali S; From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), Stanford University School of Medicine, Palo Alto, CA; French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hôpital Neurologique; Synatac Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM U1217/CNRS UMR5310, Université Claude Bernard Lyon 1, Université de Lyon, France; Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and S.D.), University of California, San Francisco; Department of Neurology (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University of Oxford, United Kingdom.
Lee ST; From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), Stanford University School of Medicine, Palo Alto, CA; French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hôpital Neurologique; Synatac Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM U1217/CNRS UMR5310, Université Claude Bernard Lyon 1, Université de Lyon, France; Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and S.D.), University of California, San Francisco; Department of Neurology (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University of Oxford, United Kingdom.
Knight J; From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), Stanford University School of Medicine, Palo Alto, CA; French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hôpital Neurologique; Synatac Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM U1217/CNRS UMR5310, Université Claude Bernard Lyon 1, Université de Lyon, France; Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and S.D.), University of California, San Francisco; Department of Neurology (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University of Oxford, United Kingdom.
Elliott KS; From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), Stanford University School of Medicine, Palo Alto, CA; French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hôpital Neurologique; Synatac Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM U1217/CNRS UMR5310, Université Claude Bernard Lyon 1, Université de Lyon, France; Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and S.D.), University of California, San Francisco; Department of Neurology (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University of Oxford, United Kingdom.
Irani S; From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), Stanford University School of Medicine, Palo Alto, CA; French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hôpital Neurologique; Synatac Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM U1217/CNRS UMR5310, Université Claude Bernard Lyon 1, Université de Lyon, France; Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and S.D.), University of California, San Francisco; Department of Neurology (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University of Oxford, United Kingdom.
Honnorat J; From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), Stanford University School of Medicine, Palo Alto, CA; French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hôpital Neurologique; Synatac Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM U1217/CNRS UMR5310, Université Claude Bernard Lyon 1, Université de Lyon, France; Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and S.D.), University of California, San Francisco; Department of Neurology (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University of Oxford, United Kingdom.
Mignot E; From the Stanford University Center for Sleep Sciences (V.P.S., A.A., and E.M.), Stanford University School of Medicine, Palo Alto, CA; French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (S.M.-C., A.-L.P., V.R., and J.H.), Hospices Civils de Lyon, Hôpital Neurologique; Synatac Team (S.M.-C., A.-L.P., V.R., and J.H.), NeuroMyoGene Institute, INSERM U1217/CNRS UMR5310, Université Claude Bernard Lyon 1, Université de Lyon, France; Oxford Autoimmune Neurology Group (S.B. and S.I.), Nuffield Department of Clinical Neurosciences, University of Oxford; Department of Neurology (S.B. and S.I.), John Radcliffe Hospital, Oxford, United Kingdom; Department of Laboratory Medicine and Pathology (S.J.P. and D.D.), and Department of Neurology (S.J.P. and D.D.), Mayo Clinic, Rochester, MN; Department of Neurology (M.D.G., J.M.G., and S.D.), University of California, San Francisco; Department of Neurology (S.-T.L.), Seoul National University Hospital, South Korea; and Wellcome Centre for Human Genetics (J.K. and K.S.E.), Nuffield Department of Medicine, University of Oxford, United Kingdom. .
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Źródło :
Neurology(R) neuroimmunology & neuroinflammation [Neurol Neuroimmunol Neuroinflamm] 2022 Feb 03; Vol. 9 (2). Date of Electronic Publication: 2022 Feb 03 (Print Publication: 2022).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Autoimmune Diseases of the Nervous System*/genetics
Autoimmune Diseases of the Nervous System*/immunology
Encephalitis*/genetics
Encephalitis*/immunology
Genome-Wide Association Study*
HLA-DRB1 Chains/*genetics
Intracellular Signaling Peptides and Proteins/*immunology
Aged ; Autoantibodies ; Female ; Genetic Association Studies ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł :
Phenome-Wide Association Studies.
Autorzy :
Bastarache L; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee.
Denny JC; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; All of Us Research Program, National Institutes of Health, Bethesda, Maryland.
Roden DM; Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee.
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Źródło :
JAMA [JAMA] 2022 Jan 04; Vol. 327 (1), pp. 75-76.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Genetic Association Studies*
Phenotype*
Datasets as Topic ; Genome-Wide Association Study ; Humans ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł :
Systematic review and meta-analysis of genetic association studies of pelvic organ prolapse.
Autorzy :
Allen-Brady K; Department of Internal Medicine, Genetic Epidemiology, University of Utah, Salt Lake City, UT, USA.
Chua JWF; Zhongshan Hospital, Fudan University, Shanghai, China.
Cuffolo R; Department of Obstetrics & Gynaecology, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, UK.
Koch M; Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
Sorrentino F; Department of Medical and Surgical Sciences, Institute of Obstetrics and Gynecology, University of Foggia, Foggia, Italy.
Cartwright R; Department of Epidemiology & Biostatistics, Imperial College London, Norfolk Place, London, UK. .; Department of Urogynaecology, LNWH NHS Trust, London, UK. .
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Źródło :
International urogynecology journal [Int Urogynecol J] 2022 Jan; Vol. 33 (1), pp. 67-82. Date of Electronic Publication: 2021 Apr 24.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Genome-Wide Association Study*
Pelvic Organ Prolapse*/genetics
Genetic Association Studies ; Humans ; Polymorphism, Genetic
Czasopismo naukowe
Tytuł :
Two-phase sample selection strategies for design and analysis in post-genome-wide association fine-mapping studies.
Autorzy :
Espin-Garcia O; Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Craiu RV; Department of Statistical Sciences, Faculty of Arts and Sciences, University of Toronto, Toronto, Ontario, Canada.
Bull SB; Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario, Canada.
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Źródło :
Statistics in medicine [Stat Med] 2021 Dec 30; Vol. 40 (30), pp. 6792-6817. Date of Electronic Publication: 2021 Oct 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome-Wide Association Study*
Polymorphism, Single Nucleotide*
Genetic Association Studies ; Genotype ; Humans ; Phenotype
Czasopismo naukowe
Tytuł :
Genetic association tests in family samples for multi-category phenotypes.
Autorzy :
Wang S; Pfizer Inc, Global Product Development, Groton, CT, 06340, USA. .
Meigs JB; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.
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Źródło :
BMC genomics [BMC Genomics] 2021 Dec 04; Vol. 22 (1), pp. 873. Date of Electronic Publication: 2021 Dec 04.
Typ publikacji :
Journal Article
MeSH Terms :
Genome-Wide Association Study*
Models, Genetic*
Genetic Association Studies ; Humans ; Phenotype ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł :
Trans-ethnic meta-analysis of rare variants in sequencing association studies.
Autorzy :
Shi J; Thomas Francis, Jr. School of Public Health II, 1420 Washington Heights, Ann Arbor, MI 48109, USA.
Boehnke M; Thomas Francis, Jr. School of Public Health II, 1420 Washington Heights, Ann Arbor, MI 48109, USA.
Lee S; Thomas Francis, Jr. School of Public Health II, 1420 Washington Heights, Ann Arbor, MI 48109, USA.
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Źródło :
Biostatistics (Oxford, England) [Biostatistics] 2021 Oct 13; Vol. 22 (4), pp. 706-722.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome-Wide Association Study*
Models, Genetic*
Computer Simulation ; Genetic Association Studies ; Genetic Variation/genetics ; Humans ; Phenotype
Czasopismo naukowe
Tytuł :
Genome-wide association study in the Taiwan Biobank identifies four novel genes for human height: NABP2, RASA2, RNF41 and SLC39A5.
Autorzy :
Lin E; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.; Department of Electrical & Computer Engineering, University of Washington, Seattle, WA 98195, USA.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Tsai SJ; Department of Psychiatry, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; Division of Psychiatry, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Kuo PH; Department of Public Health, Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei 10617, Taiwan.
Liu YL; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County 35053, Taiwan.
Yang AC; Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.; Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Conomos MP; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Thornton TA; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
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Źródło :
Human molecular genetics [Hum Mol Genet] 2021 Nov 16; Vol. 30 (23), pp. 2362-2369.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Specimen Banks*
Genome-Wide Association Study*
Body Height/*genetics
Cation Transport Proteins/*genetics
Ubiquitin-Protein Ligases/*genetics
ras GTPase-Activating Proteins/*genetics
Adult ; Alleles ; Female ; Genetic Association Studies ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; Taiwan
Czasopismo naukowe
Tytuł :
Metabolite Diversity and Metabolic Genome-Wide Marker Association Studies (Mgwas) for Health Benefiting Nutritional Traits in Pearl Millet Grains.
Autorzy :
Yadav CB; Institute of Biological Environmental and Rural Sciences (IBERS), Aberystwyth University, Plas Gogerddan, Aberystwyth SY23 3 EB, UK.
Srivastava RK; International Crops Research Institute for the Semi-Arid Tropics, Patancheru, Hyderabad 502324, India.
Gangashetty PI; International Crops Research Institute for the Semi-Arid Tropics, Patancheru, Hyderabad 502324, India.
Yadav R; Institute of Biological Environmental and Rural Sciences (IBERS), Aberystwyth University, Plas Gogerddan, Aberystwyth SY23 3 EB, UK.
Mur LAJ; Institute of Biological Environmental and Rural Sciences (IBERS), Aberystwyth University, Plas Gogerddan, Aberystwyth SY23 3 EB, UK.
Yadav RS; Institute of Biological Environmental and Rural Sciences (IBERS), Aberystwyth University, Plas Gogerddan, Aberystwyth SY23 3 EB, UK.
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Źródło :
Cells [Cells] 2021 Nov 08; Vol. 10 (11). Date of Electronic Publication: 2021 Nov 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome, Plant*
Genome-Wide Association Study*
Health*
Nutritional Physiological Phenomena*
Metabolome/*genetics
Pennisetum/*genetics
Pennisetum/*metabolism
Genetic Association Studies ; Genetic Markers ; Humans ; Metabolic Networks and Pathways ; Principal Component Analysis ; Seeds/genetics
Czasopismo naukowe
Tytuł :
Identification of candidate genes on the basis of SNP by time-lagged heat stress interactions for milk production traits in German Holstein cattle.
Autorzy :
Halli K; Institute of Animal Breeding and Genetics, Justus-Liebig-University Gießen, Gießen, Germany.
Vanvanhossou SF; Institute of Animal Breeding and Genetics, Justus-Liebig-University Gießen, Gießen, Germany.
Bohlouli M; Institute of Animal Breeding and Genetics, Justus-Liebig-University Gießen, Gießen, Germany.
König S; Institute of Animal Breeding and Genetics, Justus-Liebig-University Gießen, Gießen, Germany.
Yin T; Institute of Animal Breeding and Genetics, Justus-Liebig-University Gießen, Gießen, Germany.
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Źródło :
PloS one [PLoS One] 2021 Oct 14; Vol. 16 (10), pp. e0258216. Date of Electronic Publication: 2021 Oct 14 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Association Studies*
Heat-Shock Response/*genetics
Milk/*metabolism
Polymorphism, Single Nucleotide/*genetics
Animals ; Cattle ; Female ; Genome ; Genome-Wide Association Study ; Genotype ; Humidity ; Lactation/genetics ; Pregnancy ; Temperature
Czasopismo naukowe
Tytuł :
Assessing the impact of alcohol consumption on the genetic contribution to mean corpuscular volume.
Autorzy :
Thompson A; Wolfson Centre for Personalised Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3GL, UK.; MRC Centre for Drug Safety Science, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3GL, UK.; Liverpool Centre for Alcohol Research, University of Liverpool, Liverpool L69 3BX, UK.
King K; Wolfson Centre for Personalised Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3GL, UK.; MRC Centre for Drug Safety Science, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3GL, UK.; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9NT, UK.
Morris AP; Division of Musculoskeletal and Dermatological Sciences, Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester M13 9PL, UK.; Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK.
Pirmohamed M; Wolfson Centre for Personalised Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3GL, UK.; MRC Centre for Drug Safety Science, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3GL, UK.; Liverpool Centre for Alcohol Research, University of Liverpool, Liverpool L69 3BX, UK.; Liverpool University Hospital, Liverpool L9 7AL, UK.; Liverpool Health Partners, Liverpool L3 5TF, UK.
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Źródło :
Human molecular genetics [Hum Mol Genet] 2021 Oct 13; Vol. 30 (21), pp. 2040-2051.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alcohol Drinking*
Genetic Association Studies*
Health Impact Assessment*
Quantitative Trait Loci*
Quantitative Trait, Heritable*
Erythrocyte Indices/*genetics
Aged ; Alleles ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Male ; Mendelian Randomization Analysis ; Metabolic Networks and Pathways ; Middle Aged ; Polymorphism, Single Nucleotide ; Population Surveillance
Czasopismo naukowe
Tytuł :
A cross-population atlas of genetic associations for 220 human phenotypes.
Autorzy :
Sakaue S; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan. .; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. .; Center for Data Sciences, Harvard Medical School, Boston, MA, USA. .; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. .; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. .
Kanai M; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Tanigawa Y; Department of Biomedical Data Science, School of Medicine, Stanford University, Stanford, CA, USA.
Karjalainen J; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Kurki M; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Koshiba S; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Sendai, Japan.
Narita A; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Konuma T; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Yamamoto K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.
Akiyama M; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ishigaki K; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Center for Data Sciences, Harvard Medical School, Boston, MA, USA.; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Suzuki A; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Suzuki K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Obara W; Department of Urology, Iwate Medical University, Iwate, Japan.
Yamaji K; Department of Internal Medicine and Rheumatology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Takahashi K; Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Asai S; Division of Pharmacology, Department of Biomedical Science, Nihon University School of Medicine, Tokyo, Japan.; Division of Genomic Epidemiology and Clinical Trials, Clinical Trials Research Center, Nihon University School of Medicine, Tokyo, Japan.
Takahashi Y; Division of Genomic Epidemiology and Clinical Trials, Clinical Trials Research Center, Nihon University School of Medicine, Tokyo, Japan.
Suzuki T; Tokushukai Group, Tokyo, Japan.
Shinozaki N; Tokushukai Group, Tokyo, Japan.
Yamaguchi H; Department of Hematology, Nippon Medical School, Tokyo, Japan.
Minami S; Department of Bioregulation, Nippon Medical School, Kawasaki, Japan.
Murayama S; Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
Yoshimori K; Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.
Nagayama S; The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
Obata D; Center for Clinical Research and Advanced Medicine, Shiga University of Medical Science, Otsu, Japan.
Higashiyama M; Department of General Thoracic Surgery, Osaka International Cancer Institute, Osaka, Japan.
Masumoto A; Aso Iizuka Hospital, Fukuoka, Japan.
Koretsune Y; National Hospital Organization Osaka National Hospital, Osaka, Japan.
Ito K; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Terao C; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yamauchi T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Komuro I; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Toranomon Hospital, Tokyo, Japan.
Tamiya G; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Sendai, Japan.; Graduate School of Medicine, Tohoku University, Sendai, Japan.; Center for Advanced Intelligence Project, RIKEN, Tokyo, Japan.
Yamamoto M; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Sendai, Japan.; Graduate School of Medicine, Tohoku University, Sendai, Japan.
Nakamura Y; Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
Kubo M; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Murakami Y; Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Yamamoto K; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Kamatani Y; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Palotie A; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Analytic and Translational Genetics Unit, Department of Medicine, and the Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Rivas MA; Department of Biomedical Data Science, School of Medicine, Stanford University, Stanford, CA, USA.
Daly MJ; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Matsuda K; Department of Computational Biology and Medical Sciences, Graduate school of Frontier Sciences, The University of Tokyo, Tokyo, Japan. .
Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan. .; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. .; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan. .; Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Analytic and Translational Genetics Unit, Department of Medicine, and the Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. .; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan. .
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Corporate Authors :
FinnGen
Źródło :
Nature genetics [Nat Genet] 2021 Oct; Vol. 53 (10), pp. 1415-1424. Date of Electronic Publication: 2021 Sep 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Association Studies*
Genetic Predisposition to Disease*
ABO Blood-Group System/genetics ; Biological Specimen Banks ; Genetic Loci ; Genetic Pleiotropy ; Genome-Wide Association Study ; Humans ; Major Histocompatibility Complex/genetics ; Meta-Analysis as Topic ; Mutation/genetics ; Phenotype
Czasopismo naukowe
Tytuł :
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.
Autorzy :
Karlsson Linnér R; Department of Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Mallard TT; Department of Psychology, University of Texas at Austin, Austin, TX, USA.
Barr PB; Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
Sanchez-Roige S; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Madole JW; Department of Psychology, University of Texas at Austin, Austin, TX, USA.
Driver MN; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Poore HE; Department of Psychology, Emory University, Atlanta, GA, USA.
de Vlaming R; Department of Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Grotzinger AD; Department of Psychology, University of Texas at Austin, Austin, TX, USA.
Tielbeek JJ; Department of Complex Trait Genetics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Johnson EC; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Liu M; Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Rosenthal SB; Center for Computational Biology and Bioinformatics, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Ideker T; Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Zhou H; Department of Psychiatry, Yale University School of Medicine, West Haven, CT, USA.; Department of Psychiatry, VA CT Healthcare System, West Haven, CT, USA.
Kember RL; Center for Studies of Addiction, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.; Mental Illness Research Education and Clinical Center, Crescenz VA Medical Center, Philadelphia, PA, USA.
Pasman JA; Behavioural Science Institute, Radboud University Nijmegen, Nijmegen, the Netherlands.
Verweij KJH; Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Liu DJ; Department of Public Health Sciences, Penn State University, Hershey, PA, USA.; Institute of Personalized Medicine, Penn State University, Hershey, PA, USA.
Vrieze S; Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Kranzler HR; Center for Studies of Addiction, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.; Mental Illness Research Education and Clinical Center, Crescenz VA Medical Center, Philadelphia, PA, USA.
Gelernter J; Department of Psychiatry, Yale University School of Medicine, West Haven, CT, USA.; Department of Psychiatry, VA CT Healthcare System, West Haven, CT, USA.; Department of Genetics, Yale University School of Medicine, West Haven, CT, USA.; Department of Neuroscience, Yale University School of Medicine, West Haven, CT, USA.
Harris KM; Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Tucker-Drob EM; Department of Psychology, University of Texas at Austin, Austin, TX, USA.; Population Research Center, University of Texas at Austin, Austin, TX, USA.
Waldman ID; Department of Psychology, Emory University, Atlanta, GA, USA.; Center for Computational and Quantitative Genetics, Emory University, Atlanta, GA, USA.
Palmer AA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA.
Harden KP; Department of Psychology, University of Texas at Austin, Austin, TX, USA.; Population Research Center, University of Texas at Austin, Austin, TX, USA.
Koellinger PD; Department of Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. .; La Follette School of Public Affairs, University of Wisconsin-Madison, Madison, WI, USA. .
Dick DM; Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA. .; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA. .
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Corporate Authors :
COGA Collaborators
Źródło :
Nature neuroscience [Nat Neurosci] 2021 Oct; Vol. 24 (10), pp. 1367-1376. Date of Electronic Publication: 2021 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Association Studies*
Self-Control*
Behavior, Addictive/*genetics
Attention Deficit Disorder with Hyperactivity/genetics ; Behavior, Addictive/psychology ; Behavioral Symptoms/genetics ; Behavioral Symptoms/psychology ; Computational Biology ; Crime/psychology ; Genome-Wide Association Study ; HIV Infections/genetics ; HIV Infections/psychology ; Humans ; Meta-Analysis as Topic ; Multifactorial Inheritance ; Multivariate Analysis ; Opioid-Related Disorders/genetics ; Opioid-Related Disorders/psychology ; Reproducibility of Results ; Suicide ; Unemployment
Czasopismo naukowe
Tytuł :
Advances in mouse genetics for the study of human disease.
Autorzy :
Brown SDM; MRC Harwell Institute, Harwell OX12 0RD, UK.
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Źródło :
Human molecular genetics [Hum Mol Genet] 2021 Oct 01; Vol. 30 (R2), pp. R274-R284.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Genetic Association Studies*/methods
Genetic Predisposition to Disease*
Genome*
Genomics*/methods
Alleles ; Animals ; Disease Models, Animal ; Drug Discovery ; Gene Expression Regulation ; Genetic Engineering ; Genome-Wide Association Study ; High-Throughput Screening Assays ; Humans ; Mice ; Mutagenesis ; Mutation ; Phenomics/methods ; Phenotype ; Precision Medicine ; Signal Transduction ; Translational Research, Biomedical
Czasopismo naukowe
Tytuł :
Powerful use of automated prioritization of candidate variants in genetic hearing loss with extreme etiologic heterogeneity.
Autorzy :
Kim SY; Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
Lee S; Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.; R&D Center, ENCell Co. Ltd, Seoul, Republic of Korea.
Seo GH; 3billion, Inc., Seoul, Republic of Korea.
Kim BJ; Department of Otolaryngology-Head and Neck Surgery, Chungnam National University Sejong Hospital, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
Oh DY; Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Han JH; Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Park MK; Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Lee SM; Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
Kim B; Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Yi N; Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Kim NJ; Department of Biological Sciences, Vanderbilt University, Nashville, USA.
Koh DH; Department of Biomedical Science, The Graduate School, CHA University, Seongnam, Republic of Korea.
Hwang S; Department of Biomedical Science, The Graduate School, CHA University, Seongnam, Republic of Korea.; Department of Pathology, CHA University, CHA Bundang Medical Center, Seongnam, Republic of Korea.
Keum C; 3billion, Inc., Seoul, Republic of Korea. .
Choi BY; Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. .
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Źródło :
Scientific reports [Sci Rep] 2021 Sep 30; Vol. 11 (1), pp. 19476. Date of Electronic Publication: 2021 Sep 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Susceptibility*
Genetic Association Studies*/methods
Genetic Heterogeneity*
Genetic Variation*
Hearing Loss/*genetics
Alleles ; Female ; Genome-Wide Association Study ; Genotype ; Hearing Loss/diagnosis ; Humans ; Infant ; Infant, Newborn ; Male ; Nucleic Acid Amplification Techniques ; Phenotype ; Whole Exome Sequencing
Czasopismo naukowe

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