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Tytuł :
Noninvasive chimeric DNA profiling identifies tumor-originated HBV integrants contributing to viral antigen expression in liver cancer.
Autorzy :
Chen W; Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, NO.1 Beichen West Road, Chaoyang, Beijing, 100101, China.; Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.
Zhang K; Institute of Virology, Technical University of Munich/Helmholtz Zentrum München, Trogerstrasse 30, 81675, Munich, Germany.; Janssen China Research and Development Center, Shanghai, 201210, China.
Dong P; Department of Hepatology, Beijing You'an Hospital Affiliated with Capital Medical University, Beijing, 100069, China.
Fanning G; Janssen China Research and Development Center, Shanghai, 201210, China.
Tao C; Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, NO.1 Beichen West Road, Chaoyang, Beijing, 100101, China.
Zhang H; Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, NO.1 Beichen West Road, Chaoyang, Beijing, 100101, China.
Guo S; Center for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, WI, USA.
Wang Z; Department of Hepatology, Beijing You'an Hospital Affiliated with Capital Medical University, Beijing, 100069, China.
Hong Y; Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, NO.1 Beichen West Road, Chaoyang, Beijing, 100101, China.; Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Yang X; Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Lai S; Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, NO.1 Beichen West Road, Chaoyang, Beijing, 100101, China.
Ding H; Department of Hepatology, Beijing You'an Hospital Affiliated with Capital Medical University, Beijing, 100069, China.
Zhao H; Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Zeng C; Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, NO.1 Beichen West Road, Chaoyang, Beijing, 100101, China. .
Protzer U; Institute of Virology, Technical University of Munich/Helmholtz Zentrum München, Trogerstrasse 30, 81675, Munich, Germany. .; German Center for Infection Research (DZIF), Munich Partner Site, Munich, Germany. .
Zhang D; Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, NO.1 Beichen West Road, Chaoyang, Beijing, 100101, China. .; Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China. .
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Źródło :
Hepatology international [Hepatol Int] 2020 May; Vol. 14 (3), pp. 326-337. Date of Electronic Publication: 2020 Feb 25.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular*/immunology
Carcinoma, Hepatocellular*/pathology
Carcinoma, Hepatocellular*/virology
Hepatitis B virus*/genetics
Hepatitis B virus*/immunology
Hepatitis B virus*/isolation & purification
Hepatitis B, Chronic*/blood
Hepatitis B, Chronic*/complications
Hepatitis B, Chronic*/virology
Integration Host Factors*/blood
Integration Host Factors*/isolation & purification
Liver*/pathology
Liver*/virology
Liver Neoplasms*/immunology
Liver Neoplasms*/pathology
Liver Neoplasms*/virology
DNA, Viral/*analysis
Antigens, Viral/immunology ; Cell-Free Nucleic Acids/blood ; Female ; Host Microbial Interactions ; Humans ; Immunotherapy/methods ; Male ; Middle Aged ; Reproducibility of Results ; Saliva/virology ; Virus Integration ; alpha-Fetoproteins/analysis
Czasopismo naukowe
Tytuł :
No evidence of human genome integration of SARS-CoV-2 found by long-read DNA sequencing.
Autorzy :
Smits N; Mater Research Institute, University of Queensland, TRI Building, Woolloongabba, QLD 4102, Australia.
Rasmussen J; Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
Bodea GO; Mater Research Institute, University of Queensland, TRI Building, Woolloongabba, QLD 4102, Australia; Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
Amarilla AA; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia.
Gerdes P; Mater Research Institute, University of Queensland, TRI Building, Woolloongabba, QLD 4102, Australia.
Sanchez-Luque FJ; GENYO, Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research, PTS Granada 18016, Spain; MRC Human Genetics Unit, Institute of Genetics and Cancer (IGC), University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
Ajjikuttira P; Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
Modhiran N; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia.
Liang B; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia.
Faivre J; INSERM, U1193, Paul-Brousse University Hospital, Hepatobiliary Centre, Villejuif 94800, France.
Deveson IW; Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Khromykh AA; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia; Australian Infectious Diseases Research Centre, Global Virus Network Centre of Excellence, Brisbane, QLD 4072, Australia.
Watterson D; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia; Australian Infectious Diseases Research Centre, Global Virus Network Centre of Excellence, Brisbane, QLD 4072, Australia.
Ewing AD; Mater Research Institute, University of Queensland, TRI Building, Woolloongabba, QLD 4102, Australia.
Faulkner GJ; Mater Research Institute, University of Queensland, TRI Building, Woolloongabba, QLD 4102, Australia; Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2021 Aug 17; Vol. 36 (7), pp. 109530. Date of Electronic Publication: 2021 Jul 28.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome, Human*
Sequence Analysis, DNA*
Virus Integration*
COVID-19/*virology
DNA, Viral/*genetics
SARS-CoV-2/*genetics
Aged ; Animals ; COVID-19/diagnosis ; Carcinoma, Hepatocellular/virology ; Chlorocebus aethiops ; HEK293 Cells ; Hepatitis B virus/genetics ; Host-Pathogen Interactions ; Humans ; Liver Neoplasms/virology ; Long Interspersed Nucleotide Elements ; Male ; Nanopore Sequencing ; Vero Cells
Czasopismo naukowe
Tytuł :
Control of the Serine Integrase Reaction: Roles of the Coiled-Coil and Helix E Regions in DNA Site Synapsis and Recombination.
Autorzy :
Mandali S; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Johnson RC; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, USA.
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Źródło :
Journal of bacteriology [J Bacteriol] 2021 Jul 22; Vol. 203 (16), pp. e0070320. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Chromosome Pairing*
Virus Integration*
Bacteriophages/*enzymology
Integrases/*chemistry
Integrases/*metabolism
Listeria monocytogenes/*virology
Viral Proteins/*chemistry
Viral Proteins/*metabolism
Amino Acid Motifs ; Attachment Sites, Microbiological ; Bacteriophages/chemistry ; Bacteriophages/genetics ; Bacteriophages/physiology ; Integrases/genetics ; Listeria monocytogenes/genetics ; Prophages/chemistry ; Prophages/enzymology ; Prophages/genetics ; Prophages/physiology ; Protein Domains ; Recombination, Genetic ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
rigrag: high-resolution mapping of genic targeting preferences during HIV-1 integration in vitro and in vivo.
Autorzy :
Bedwell GJ; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Jang S; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Li W; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Singh PK; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Engelman AN; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jul 21; Vol. 49 (13), pp. 7330-7346.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Virus Integration*
Genomics/*methods
HIV-1/*genetics
Adaptor Proteins, Signal Transducing/physiology ; HEK293 Cells ; HIV Infections/genetics ; Humans ; Jurkat Cells ; Models, Biological ; Proviruses ; Transcription Factors/physiology
Czasopismo naukowe
Tytuł :
The latest trends in power electronics: It's not just about stand-alone devices anymore, as power systems designers tackle power density, thermal management, open-architecture standards, systems integration, and obsolescence management.
Autorzy :
Keller, John
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Temat :
SYSTEM integration
POWER density
POWER electronics
UNINTERRUPTIBLE power supply
MILITARY electronics
LOW voltage integrated circuits
AVIONICS
Źródło :
Military & Aerospace Electronics. Apr2021, Vol. 32 Issue 4, p23-29. 6p.
Periodyk
Tytuł :
Relationship between quality of life and social integration among patients with schizophrenia attending a Nigerian tertiary hospital.
Autorzy :
Ogundare T; Neuropsychiatric Hospital, PMB 2002, Aro, Abeokuta, Ogun State, Nigeria. .; School of Public Health, Boston University, Boston, MA, 02118, USA. .
Onifade PO; Neuropsychiatric Hospital, PMB 2002, Aro, Abeokuta, Ogun State, Nigeria.
Ogundapo '; Neuropsychiatric Hospital, PMB 2002, Aro, Abeokuta, Ogun State, Nigeria.
Ghebrehiwet S; Department of Psychiatry, Boston Medical Center, Boston, MA, 02118, USA.
Borba CPC; Boston University School of Medicine, Boston, MA, 02118, USA.; Department of Psychiatry, Boston Medical Center, Boston, MA, 02118, USA.
Henderson DC; Boston University School of Medicine, Boston, MA, 02118, USA.; Department of Psychiatry, Boston Medical Center, Boston, MA, 02118, USA.
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Źródło :
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation [Qual Life Res] 2021 Jun; Vol. 30 (6), pp. 1665-1674. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article
MeSH Terms :
Interpersonal Relations*
Schizophrenic Psychology*
Social Integration*
Quality of Life/*psychology
Schizophrenia/*therapy
Adult ; Deinstitutionalization/methods ; Female ; Humans ; Male ; Middle Aged ; Nigeria ; Psychometrics ; Surveys and Questionnaires ; Tertiary Care Centers ; Young Adult
Czasopismo naukowe
Tytuł :
Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues.
Autorzy :
Zhang L; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
Richards A; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
Barrasa MI; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
Hughes SH; HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702.
Young RA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142.
Jaenisch R; Whitehead Institute for Biomedical Research, Cambridge, MA 02142; .; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 May 25; Vol. 118 (21).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*genetics
COVID-19/*virology
SARS-CoV-2/*genetics
Virus Integration/*genetics
Animals ; COVID-19/metabolism ; Chlorocebus aethiops ; Genome, Viral ; HEK293 Cells ; Humans ; RNA, Viral/genetics ; SARS-CoV-2/metabolism ; Vero Cells ; Virus Integration/physiology ; Virus Replication/genetics ; Virus Replication/physiology
Czasopismo naukowe
Tytuł :
A step back from the edge: empirical modeling of the role of social integration on suicide and associated deleterious health outcomes across adolescents from six middle-income countries.
Autorzy :
Yilmaz SK; Department of Economics, University of New Mexico, Albuquerque, NM, MSC 05 306087131, USA. .
Bohara AK; Department of Economics, University of New Mexico, Albuquerque, NM, MSC 05 306087131, USA.
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Źródło :
Social psychiatry and psychiatric epidemiology [Soc Psychiatry Psychiatr Epidemiol] 2021 May; Vol. 56 (5), pp. 793-805. Date of Electronic Publication: 2020 Nov 22.
Typ publikacji :
Journal Article
MeSH Terms :
Developing Countries*
Social Integration*
Adolescent ; Humans ; Income ; Outcome Assessment, Health Care ; Suicidal Ideation
Czasopismo naukowe
Tytuł :
Developing a comprehensive framework of community integration for people with acquired brain injury: a conceptual analysis.
Autorzy :
Shaikh NM; a School of Clinical Sciences , Auckland University of Technology , Auckland , New Zealand.
Kersten P; b School of Health Sciences , University of Brighton , Brighton , UK.
Siegert RJ; c School of Clinical Sciences/School of Public Health and Psychosocial Studies , Auckland University of Technology , Auckland , New Zealand.
Theadom A; d National Institute for Stroke and Applied Neurosciences , Auckland University of Technology , Auckland , New Zealand.
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Źródło :
Disability and rehabilitation [Disabil Rehabil] 2019 Jul; Vol. 41 (14), pp. 1615-1631. Date of Electronic Publication: 2018 Mar 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Community Integration*
Brain Injuries/*rehabilitation
Adaptation, Psychological ; Employment ; Housing ; Humans ; Social Integration ; Social Support ; Work
Czasopismo naukowe
Tytuł :
Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors.
Autorzy :
Delgado I; Cardiovascular Development Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Giovinazzo G; Cardiovascular Development Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Temiño S; Cardiovascular Development Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Gauthier Y; Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de Montréal, Montreal, QC, Canada.
Balsalobre A; Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de Montréal, Montreal, QC, Canada.
Drouin J; Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de Montréal, Montreal, QC, Canada.
Torres M; Cardiovascular Development Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. .
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Źródło :
Nature communications [Nat Commun] 2021 May 25; Vol. 12 (1), pp. 3086. Date of Electronic Publication: 2021 May 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Body Patterning/*genetics
Homeodomain Proteins/*genetics
Limb Buds/*metabolism
Myeloid Ecotropic Viral Integration Site 1 Protein/*genetics
Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Fibroblast Growth Factor 10/genetics ; Fibroblast Growth Factor 10/metabolism ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism ; Homeodomain Proteins/metabolism ; Limb Buds/embryology ; Mice, Knockout ; Mice, Transgenic ; Models, Genetic ; Myeloid Ecotropic Viral Integration Site 1 Protein/metabolism ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; T-Box Domain Proteins/genetics ; T-Box Domain Proteins/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcriptional Activation/genetics
Czasopismo naukowe
Tytuł :
The Process of Modeling Information System Architectures with IHE.
Autorzy :
Merzweiler A; Department MIS, Universitätsklinikum Heidelberg.
Stäubert S; Institute for Medical Informatics, Statistics and Epidemiology, Universität Leipzig.
Strübing A; Institute for Medical Informatics, Statistics and Epidemiology, Universität Leipzig.
Tonmbiak A; Department MIS, Universitätsklinikum Heidelberg.
Kaulke K; TMF e.V.
Drepper J; TMF e.V.
Bergh B; Institut für Medizinische Informatik, Universitätsklinikum Schleswig-Holstein.
Winter A; Institute for Medical Informatics, Statistics and Epidemiology, Universität Leipzig.
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Źródło :
Studies in health technology and informatics [Stud Health Technol Inform] 2021 May 24; Vol. 278, pp. 163-170.
Typ publikacji :
Journal Article
MeSH Terms :
Delivery of Health Care*
Systems Integration*
Information Systems
Czasopismo naukowe
Tytuł :
Concept and Implementation of Data Usage Proposal Process Based on International Standards in SMITH.
Autorzy :
Klötgen M; Fraunhofer Institute for Software- and Systems-Engineering ISST.
Fiege E; Fraunhofer Institute for Software- and Systems-Engineering ISST.
Houta S; Fraunhofer Institute for Software- and Systems-Engineering ISST.
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Źródło :
Studies in health technology and informatics [Stud Health Technol Inform] 2021 May 24; Vol. 278, pp. 171-179.
Typ publikacji :
Journal Article
MeSH Terms :
Delivery of Health Care*
Systems Integration*
Germany ; Reference Standards
Czasopismo naukowe
Tytuł :
Do coronavirus genes slip into human chromosomes?
Autorzy :
Cohen J
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Źródło :
Science (New York, N.Y.) [Science] 2021 May 14; Vol. 372 (6543), pp. 674-675. Date of Electronic Publication: 2021 May 13.
Typ publikacji :
Wiadomości
MeSH Terms :
Genome, Human*
Virus Integration*
COVID-19/*virology
Chromosomes, Human/*genetics
RNA, Viral/*genetics
SARS-CoV-2/*genetics
Cell Line ; Humans ; Long Interspersed Nucleotide Elements/genetics ; Reverse Transcription
Periodyk
Tytuł :
The impact of electronic health record-integrated patient-generated health data on clinician burnout.
Autorzy :
Ye J; Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
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Źródło :
Journal of the American Medical Informatics Association : JAMIA [J Am Med Inform Assoc] 2021 Apr 23; Vol. 28 (5), pp. 1051-1056.
Typ publikacji :
Journal Article
MeSH Terms :
Electronic Health Records*
Patient Generated Health Data*
Systems Integration*
Burnout, Professional/*etiology
Artificial Intelligence ; Humans ; Telemedicine ; User-Computer Interface ; Workflow ; Workload
Czasopismo naukowe

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